Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2014 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2014 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease

  • Authors:
    • Jun‑Yi Luo
    • Yi‑Tong Ma
    • Xiang Xie
    • Yi‑Ning Yang
    • Xiao‑Mei Li
    • Xiang Ma
    • Zixiang Yu
    • Bang‑Dang Chen
    • Fen Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang 830054, P.R. China
  • Pages: 1343-1348
    |
    Published online on: July 1, 2014
       https://doi.org/10.3892/mmr.2014.2360
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Intercellular adhesion molecule‑1 (ICAM‑1) is an important adhesion molecule that has a crucial role in lymphocyte migration and atherosclerosis pathogenesis activation. The aim of the present study was to explore the association between the rs5498 polymorphism of the ICAM‑1 gene and coronary heart disease (CHD). The rs5498 polymorphism of the ICAM‑1 gene was detected using polymerase chain reaction‑restriction fragment length polymorphism in 674 patients with CHD and 779 control subjects. The results showed that the frequency of the G allele was significantly higher in patients with CHD than that in controls (29.1 vs. 23.3%; P<0.001). The frequency of the AG+GG genotypes was higher in patients with CHD than that in controls (49.7 vs. 40.8%; P=0.001). Multiple logistic regression analysis showed that AG+GG was an independent risk factor for CHD (odds ratio, 1.919; 95% confidence intervals, 1.471‑2.503; P<0.001). For males, the frequencies of the G allele and AG+GG genotype were also higher in patients with CHD than those in control subjects (frequency of G allele, 29.9 vs. 22.7%; P<0.001; frequency of AG+GG genotype, 50.6 vs. 40.3%; P=0.001). For females, no significant differences in genotype or allele distribution were observed between the two groups. In conclusion, it was demonstrated in the present study that the rs5498 polymorphism of the ICAM‑1 gene was associated with CHD in males. Males with the G allele (AG and GG genotype) may therefore have a higher risk for CHD than those with the AA genotype.
View Figures

Figure 1

Figure 2

View References

1 

Hwang SJ, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, et al: Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation. 96:4219–4225. 1997. View Article : Google Scholar

2 

Mizia-Stec K, Zahorska-Markiewicz B and Goliszek L: Adhesion molecules: atherosclerosis and coronary artery disease. Przegl Lek. 60:147–150. 2003.(In Polish).

3 

Greve JM, Davis G, Meyer AM, Forte CP, Yost SC, et al: The major human rhinovirus receptor is ICAM-1. Cell. 56:839–847. 1989. View Article : Google Scholar : PubMed/NCBI

4 

Dietrich JB: The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier. J Neuroimmunol. 128:58–68. 2002. View Article : Google Scholar : PubMed/NCBI

5 

van de Stolpe A and van der Saag PT: Intercellular adhesion molecule-1. J Mol Med (Berl). 74:13–33. 1996.

6 

Watanabe T and Fan J: Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis. Int J Cardiol. 66(Suppl 1): S45–S53; discussion S55. 1998.PubMed/NCBI

7 

Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, et al: A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 107:1255–1262. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Xie X, Ma YT, Yang YN, Fu ZY, Li XM, et al: Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey. PLoS One. 5:e139972010. View Article : Google Scholar : PubMed/NCBI

9 

Gaetani E, Flex A, Pola R, Papaleo P, De Martini D, et al: The K469E polymorphism of the ICAM-1 gene is a risk factor for peripheral arterial occlusive disease. Blood Coagul Fibrinolysis. 13:483–488. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Iwao M, Morisaki H and Morisaki T: Single-nucleotide polymorphism g. 1548G > A (E469K) in human ICAM-1 gene affects mRNA splicing pattern and TPA-induced apoptosis. Biochem Biophys Res Commun. 317:729–735. 2004.PubMed/NCBI

11 

Kitagawa K, Matsumoto M, Sasaki T, Hashimoto H, Kuwabara K, et al: Involvement of ICAM-1 in the progression of atherosclerosis in APOE-knockout mice. Atherosclerosis. 160:305–310. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Hulthe J, Wikstrand J, Mattsson-Hultén L and Fagerberg B: Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study. Clin Sci (Lond). 103:123–129. 2002.PubMed/NCBI

13 

Puthothu B, Krueger M, Bernhardt M and Heinzmann A: ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels. Genes Immun. 7:322–326. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Bielinski SJ, Reiner AP, Nickerson D, Carlson C, Bailey KR, et al: Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1). Atherosclerosis. 216:390–394. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Zhou YL, Zhu MA, Ding Y, et al: Association between intercellular adhension molecule-1 gene polymorphism and coronary heart disease. J Clin Cardiol. 9:519–522. 2006.(In Chinese).

16 

Zhang SR, Xu LX, Gao QQ, Zhang HQ, Xu BS, et al: The correlation between ICAM-1 gene K469E polymorphism and coronary heart disease. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 23:205–207. 2006.(In Chinese).

17 

Lu FH, Shang Q, Wen PE, Su GH, Wu JM, et al: A study on K469E polymorphism of ICAM1 gene and ICAM1 plasma level in patients with coronary heart disease. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 23:195–197. 2006.(In Chinese).

18 

Mohamed AA, Rashed L, Amin H, Abu-Farha M, El Fadl SA and Pakhoum S: K469E polymorphism of the intercellular adhesion molecule-1 gene in Egyptians with coronary heart disease. Ann Saudi Med. 30:432–436. 2010.PubMed/NCBI

19 

McGlinchey PG, Spence MS, Patterson CC, Allen AR, Murphy G, et al: The intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism is not associated with ischaemic heart disease: an investigation using family-based tests of association. Eur J Immunogenet. 31:201–206. 2004. View Article : Google Scholar

20 

Aminian B, Abdi Ardekani AR and Arandi N: ICAM-1 polymorphisms (G241R, K469E), in coronary artery disease and myocardial infarction. Iran J Immunol. 4:227–235. 2007.PubMed/NCBI

21 

Milutinović A and Petrovic D: The K469E polymorphism of the intracellular adhesion molecule 1 (ICAM-1) gene is not associated with myocardial infarction in Caucasians with type 2 diabetes. Folia Biol (Praha). 52:79–80. 2006.PubMed/NCBI

22 

Wang MY, Bai DC, Zhu P, Fu Y, Bu DF and Zhang Y: Effects of ICAM-1 gene K469E, K56M polymorphisms on plasma sICAM-1 expression levels in Chinese Yugur, Tibetan and Han nationalities. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 20:1205–1211. 2012.(In Chinese).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Luo JY, Ma YT, Xie X, Yang YN, Li XM, Ma X, Yu Z, Chen BD and Liu F: Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease. Mol Med Rep 10: 1343-1348, 2014.
APA
Luo, J., Ma, Y., Xie, X., Yang, Y., Li, X., Ma, X. ... Liu, F. (2014). Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease. Molecular Medicine Reports, 10, 1343-1348. https://doi.org/10.3892/mmr.2014.2360
MLA
Luo, J., Ma, Y., Xie, X., Yang, Y., Li, X., Ma, X., Yu, Z., Chen, B., Liu, F."Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease". Molecular Medicine Reports 10.3 (2014): 1343-1348.
Chicago
Luo, J., Ma, Y., Xie, X., Yang, Y., Li, X., Ma, X., Yu, Z., Chen, B., Liu, F."Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease". Molecular Medicine Reports 10, no. 3 (2014): 1343-1348. https://doi.org/10.3892/mmr.2014.2360
Copy and paste a formatted citation
x
Spandidos Publications style
Luo JY, Ma YT, Xie X, Yang YN, Li XM, Ma X, Yu Z, Chen BD and Liu F: Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease. Mol Med Rep 10: 1343-1348, 2014.
APA
Luo, J., Ma, Y., Xie, X., Yang, Y., Li, X., Ma, X. ... Liu, F. (2014). Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease. Molecular Medicine Reports, 10, 1343-1348. https://doi.org/10.3892/mmr.2014.2360
MLA
Luo, J., Ma, Y., Xie, X., Yang, Y., Li, X., Ma, X., Yu, Z., Chen, B., Liu, F."Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease". Molecular Medicine Reports 10.3 (2014): 1343-1348.
Chicago
Luo, J., Ma, Y., Xie, X., Yang, Y., Li, X., Ma, X., Yu, Z., Chen, B., Liu, F."Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease". Molecular Medicine Reports 10, no. 3 (2014): 1343-1348. https://doi.org/10.3892/mmr.2014.2360
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team