microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin

Wang,Lun‑Qing; Chen,Gang; Liu,Xiang‑Yan; Liu,Fan‑Ying; Jiang,Shao‑Yan; Wang,Zhou

doi:10.3892/mmr.2014.2361

September-2014 Volume 10 Issue 3

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September-2014 Volume 10 Issue 3

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Article

microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin

Authors:
- Lun‑Qing Wang
- Gang Chen
- Xiang‑Yan Liu
- Fan‑Ying Liu
- Shao‑Yan Jiang
- Zhou Wang
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Cardiology, The Affiliated Cardiovascular Hospital of Medical College, Qingdao University, Jinan, Shandong 266071, P.R. China
Pages: 1537-1542
|
Published online on: July 1, 2014

https://doi.org/10.3892/mmr.2014.2361
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Abstract

microRNAs play important roles in numerous biological processes, including tumorigenesis, by modulating critical gene transcripts. In the present study, the role of microRNA‑802 (miR‑802) in lung cancer was investigated. The results of the quantitative polymerase chain reaction revealed that expression levels of miR‑802 were significantly upregulated in lung cancer tissues. In vitro experiments demonstrated that miR‑802 promoted cell proliferation in A549, NCI‑H358 and NCI‑H1299 cells. Furthermore, it was indicated that miR‑802 promoted the proliferation of lung carcinoma by targeting the tumor suppressor menin. Therefore, these results suggest a previously unknown miR‑802/menin molecular network controlling lung carcinoma development.

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1	Keith RL and Miller YE: Lung cancer chemoprevention: current status and future prospects. Nat Rev Clin Oncol. 10:334–343. 2013. View Article : Google Scholar : PubMed/NCBI
2	Kim VN, Han J and Siomi MC: Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 10:126–139. 2009. View Article : Google Scholar : PubMed/NCBI
3	Ameres SL and Zamore PD: Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol. 14:475–488. 2013. View Article : Google Scholar : PubMed/NCBI
4	van Kouwenhove M, Kedde M and Agami R: MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer. 11:644–656. 2011.PubMed/NCBI
5	Kasinski AL and Slack FJ: Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer. 11:849–864. 2011. View Article : Google Scholar
6	Nana-Sinkam SP and Croce CM: Clinical applications for microRNAs in cancer. Clin Pharmacol Ther. 93:98–104. 2013. View Article : Google Scholar
7	Sittka A and Schmeck B: MicroRNAs in the lung. Adv Exp Med Biol. 774:121–134. 2013. View Article : Google Scholar
8	Redova M, Sana J and Slaby O: Circulating miRNAs as new blood-based biomarkers for solid cancers. Future Oncol. 9:387–402. 2013. View Article : Google Scholar : PubMed/NCBI
9	Ma Q, Jiang Q, Pu Q, Zhang X, Yang W, et al: MicroRNA-143 inhibits migration and invasion of human non-small-cell lung cancer and its relative mechanism. Int J Biol Sci. 9:680–692. 2013. View Article : Google Scholar : PubMed/NCBI
10	Dweep H, Sticht C, Pandey P and Gretz N: miRWalk - database: prediction of possible miRNA binding sites by ‘walking’ the genes of 3 genomes. J Biomed Inform. 44:839–847. 2011.
11	Seigne C, Auret M, Treilleux I, Bonnavion R, Assade F, et al: High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands. J Pathol. 229:546–558. 2013. View Article : Google Scholar
12	Gang D, Hongwei H, Hedai L, Ming Z, Qian H and Zhijun L: The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma. Mol Biol Rep. 40:2461–2466. 2013.
13	Veniaminova NA, Hayes MM, Varney JM and Merchant JL: Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am J Physiol Gastrointest Liver Physiol. 303:G752–G764. 2012. View Article : Google Scholar : PubMed/NCBI
14	Sansom SE, Nuovo GJ, Martin MM, Kotha SR, Parinandi NL and Elton TS: miR-802 regulates human angiotensin II type 1 receptor expression in intestinal epithelial C2BBe1 cells. Am J Physiol Gastrointest Liver Physiol. 299:G632–G642. 2010. View Article : Google Scholar : PubMed/NCBI
15	Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, et al: Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature. 494:111–115. 2013. View Article : Google Scholar : PubMed/NCBI
16	Gaztambide S, Vazquez F and Castaño L: Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1). Minerva Endocrinol. 38:17–28. 2013.PubMed/NCBI
17	Matkar S, Thiel A and Hua X: Menin: a scaffold protein that controls gene expression and cell signaling. Trends Biochem Sci. 38:394–402. 2013. View Article : Google Scholar : PubMed/NCBI
18	Debelenko LV, Brambilla E, Agarwal SK, Swalwell JI, Kester MB, et al: Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum Mol Genet. 6:2285–2290. 1997. View Article : Google Scholar : PubMed/NCBI
19	Haruki N, Yatabe Y, Travis WD, Nomoto S, Osada H, et al: Characterization of high-grade neuroendocrine tumors of the lung in relation to menin mutations. Jpn J Cancer Res. 91:317–323. 2000. View Article : Google Scholar : PubMed/NCBI
20	Gao SB, Feng ZJ, Xu B, Wu Y, Yin P, et al: Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene. 28:4095–4104. 2009. View Article : Google Scholar : PubMed/NCBI
21	Feng ZJ, Gao SB, Wu Y, Xu XF, Hua X and Jin GH: Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin. Oncogene. 29:5416–5426. 2010.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin

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