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Article

Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol

  • Authors:
    • Sameer E. Al‑Harthi
    • Ohoud M. Alarabi
    • Wafaa S. Ramadan
    • Mohamed N. Alaama
    • Huda M. Al‑Kreathy
    • Zoheir A. Damanhouri
    • Lateef M. Khan
    • Abdel‑Moneim M. Osman
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia, Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia, Cardiology Unit, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • Pages: 1455-1460
    |
    Published online on: July 15, 2014
       https://doi.org/10.3892/mmr.2014.2384
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Abstract

Doxorubicin (DOX), is a highly active anticancer agent, but its clinical use is limited by its severe cardiotoxic side‑effects associated with increased oxidative stress and apoptosis. Resveratrol (RSVL) is a naturally occurring polyphenolic compound (trans-3,5,4'-trihydroxystilbene) found primarily in root extracts of the oriental plant Polygonum cuspidatum and of numerous additional plant species. It has recently been shown that RSVL has a number of beneficial effects in different biological systems, which include anti-oxidant, antineoplastic, anticarcinogenic, cardioprotective and antiviral effects. In this study, we examined whether RSVL has protective effects against DOX‑induced free radical production and cardiotoxicity in male rats. The tested dose of DOX (20 mg/kg) caused a significant increase in the serum activities of the cardiac enzymes lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) and the level of malondialdehyde (MDA) in the heart tissue. However, there was a significant decrease in the glutathione level in the heart tissue. Simultaneous treatment of rats with RSVL [10 mg/kg, intraperitoneal (i.p.) injection] reduced the activity of LDH and CPK and significantly reduced MDA production in the heart. The total antioxidant capacity was increased following RSVL administration. Electron microscopy examination of the heart tissue showed that DOX treatment results in massive fragmentation and lysis of the myofibrils, and that mitochondria show either vacuolization or complete loss of the cristae. Simultaneous treatment with RSVL ameliorated the effect of DOX administration on cardiac tissue, with cardiomyocytes appearing normal compared to the control samples, and mitochondria retaining their normal structure.
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Copy and paste a formatted citation
Spandidos Publications style
Al‑Harthi SE, Alarabi OM, Ramadan WS, Alaama MN, Al‑Kreathy HM, Damanhouri ZA, Khan LM and Osman AMM: Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol. Mol Med Rep 10: 1455-1460, 2014.
APA
Al‑Harthi, S.E., Alarabi, O.M., Ramadan, W.S., Alaama, M.N., Al‑Kreathy, H.M., Damanhouri, Z.A. ... Osman, A.M. (2014). Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol. Molecular Medicine Reports, 10, 1455-1460. https://doi.org/10.3892/mmr.2014.2384
MLA
Al‑Harthi, S. E., Alarabi, O. M., Ramadan, W. S., Alaama, M. N., Al‑Kreathy, H. M., Damanhouri, Z. A., Khan, L. M., Osman, A. M."Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol". Molecular Medicine Reports 10.3 (2014): 1455-1460.
Chicago
Al‑Harthi, S. E., Alarabi, O. M., Ramadan, W. S., Alaama, M. N., Al‑Kreathy, H. M., Damanhouri, Z. A., Khan, L. M., Osman, A. M."Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol". Molecular Medicine Reports 10, no. 3 (2014): 1455-1460. https://doi.org/10.3892/mmr.2014.2384
Copy and paste a formatted citation
x
Spandidos Publications style
Al‑Harthi SE, Alarabi OM, Ramadan WS, Alaama MN, Al‑Kreathy HM, Damanhouri ZA, Khan LM and Osman AMM: Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol. Mol Med Rep 10: 1455-1460, 2014.
APA
Al‑Harthi, S.E., Alarabi, O.M., Ramadan, W.S., Alaama, M.N., Al‑Kreathy, H.M., Damanhouri, Z.A. ... Osman, A.M. (2014). Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol. Molecular Medicine Reports, 10, 1455-1460. https://doi.org/10.3892/mmr.2014.2384
MLA
Al‑Harthi, S. E., Alarabi, O. M., Ramadan, W. S., Alaama, M. N., Al‑Kreathy, H. M., Damanhouri, Z. A., Khan, L. M., Osman, A. M."Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol". Molecular Medicine Reports 10.3 (2014): 1455-1460.
Chicago
Al‑Harthi, S. E., Alarabi, O. M., Ramadan, W. S., Alaama, M. N., Al‑Kreathy, H. M., Damanhouri, Z. A., Khan, L. M., Osman, A. M."Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol". Molecular Medicine Reports 10, no. 3 (2014): 1455-1460. https://doi.org/10.3892/mmr.2014.2384
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