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Article

Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function

  • Authors:
    • Ying‑Hua Xie
    • Nan Zhang
    • Lan‑Fang Li
    • Qin‑Zeng Zhang
    • Li‑Jun  Xie
    • Hong Jiang
    • Li‑Ping Li
    • Na Hao
    • Jian‑Xin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Pharmacology, Hebei Academy of Medical Sciences, Shijiazhuang, Hebei 050021, P.R. China
  • Pages: 1907-1914
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    Published online on: July 17, 2014
       https://doi.org/10.3892/mmr.2014.2391
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Abstract

Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in various physiological and pathological processes. H2S‑donating drugs have been tested to conjugate the beneficial effects of H2S with other pharmaceutical properties. It has been shown that the endogenous cystathionine‑γ‑lyase (CSE)/H2S pathway participates in myocardial ischemia injury in isolated hearts in rats. The present study aimed to investigate the cytoprotective action of H2S against acute myocardial ischemia injury in rats. Isolated rat hearts were perfused and subjected to ischemic conditions for 4 h. The hearts were assigned to five groups: Sham, model, infarct plus low‑dose (5 µmol/l) NaHS, infarct plus middle‑dose (10 µmol/l) NaHS and infarct plus high‑dose (20 µmol/l) NaHS. The administration of NaHS enhanced the activity of CSE, increased the content of H2S and reduced infarct volumes following myocardial ischemia injury. Furthermore, the administration of NaHS attenuated the injury to organelles (including the mitochondria, nucleus and myofilaments) by reducing lactate dehydrogenase activity, decreasing the level of mitochondrial malondialdehyde and increasing the activities of superoxide dismutase and glutathione peroxidase in the ischemic myocardial mitochondria. These protective effects of H2S against myocardial ischemia injury appeared to be mediated by its antioxidant activities and the preservation of mitochondrial function.
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Copy and paste a formatted citation
Spandidos Publications style
Xie YH, Zhang N, Li LF, Zhang QZ, Xie LJ, Jiang H, Li LP, Hao N and Zhang JX: Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function. Mol Med Rep 10: 1907-1914, 2014.
APA
Xie, Y., Zhang, N., Li, L., Zhang, Q., Xie, L., Jiang, H. ... Zhang, J. (2014). Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function. Molecular Medicine Reports, 10, 1907-1914. https://doi.org/10.3892/mmr.2014.2391
MLA
Xie, Y., Zhang, N., Li, L., Zhang, Q., Xie, L., Jiang, H., Li, L., Hao, N., Zhang, J."Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function". Molecular Medicine Reports 10.4 (2014): 1907-1914.
Chicago
Xie, Y., Zhang, N., Li, L., Zhang, Q., Xie, L., Jiang, H., Li, L., Hao, N., Zhang, J."Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function". Molecular Medicine Reports 10, no. 4 (2014): 1907-1914. https://doi.org/10.3892/mmr.2014.2391
Copy and paste a formatted citation
x
Spandidos Publications style
Xie YH, Zhang N, Li LF, Zhang QZ, Xie LJ, Jiang H, Li LP, Hao N and Zhang JX: Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function. Mol Med Rep 10: 1907-1914, 2014.
APA
Xie, Y., Zhang, N., Li, L., Zhang, Q., Xie, L., Jiang, H. ... Zhang, J. (2014). Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function. Molecular Medicine Reports, 10, 1907-1914. https://doi.org/10.3892/mmr.2014.2391
MLA
Xie, Y., Zhang, N., Li, L., Zhang, Q., Xie, L., Jiang, H., Li, L., Hao, N., Zhang, J."Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function". Molecular Medicine Reports 10.4 (2014): 1907-1914.
Chicago
Xie, Y., Zhang, N., Li, L., Zhang, Q., Xie, L., Jiang, H., Li, L., Hao, N., Zhang, J."Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function". Molecular Medicine Reports 10, no. 4 (2014): 1907-1914. https://doi.org/10.3892/mmr.2014.2391
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