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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2014 Volume 10 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Identification of ultraviolet B radiation‑induced microRNAs in normal human dermal papilla cells

Hwa Jun Cha, Ok‑Yeon Kim, Gang Tai Lee, Kwang Sik Lee, Jae Ho Lee, In‑Chul Park, Su‑Jae Lee, Yu Ri Kim, Kyu Joong Ahn, In‑Sook An, Sungkwan An, Seunghee Bae
Pages: 1663-1670
Published online on: 24 July 2014

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Article Open Access

Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage

Tao Yang, Jianwen Gu, Bin Kong, Yongqin Kuang, Lin Cheng, Jingmin Cheng, Xun Xia, Yuan Ma, Junhai Zhang
Pages: 1671-1678
Published online on: 25 July 2014

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Article

Intermittent cold stress enhances features of atherosclerotic plaque instability in apolipoprotein E‑deficient mice

Xi Zheng, Qiang Wang, Yan Zhang, Dachun Yang, De Li, Bing  Tang, Xiuchuan Li, Yongjian Yang, Shuangtao Ma
Pages: 1679-1684
Published online on: 07 August 2014

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Article Open Access

siRNA‑induced ABCE1 silencing inhibits proliferation and invasion of breast cancer cells

Bo Huang, Hongli Zhou, Xianping Lang, Zhiliang Liu
Pages: 1685-1690
Published online on: 28 July 2014

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Article Open Access

Homology modeling and molecular docking of human pituitary adenylate cyclase‑activating polypeptide I receptor

Lusheng Wu, Wenhua Guang, Xiaojia Chen, An Hong
Pages: 1691-1696
Published online on: 24 July 2014

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Article Open Access

Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S‑phase cell cycle arrest and apoptosis through caspase/cyclin‑CDK pathways

Bin Liu, Zhongyou Zhou, Wei Zhou, Jie Liu, Qingyu Zhang, Juan  Xia, Juntao Liu, Nianping Chen, Mingyi Li, Runzhi Zhu
Pages: 1697-1702
Published online on: 21 July 2014

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Article Open Access

Transcriptome analysis reveals the effect of oral contraceptive use on cervical cancer

Tian Gao, Jianjun Wang, Min Yang, Huaifang Li
Pages: 1703-1708
Published online on: 08 August 2014

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Article Open Access

Alterations of cell cycle control proteins SHP‑1/2, p16, CDK4 and cyclin D1 in radioresistant nasopharyngeal carcinoma cells

Gang Peng, Ru‑Bo Cao, Yue‑Hua Li, Zhen‑Wei Zou, Jing Huang, Qian Ding
Pages: 1709-1716
Published online on: 07 August 2014

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Article Open Access

A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells

Jianping Li, Tie Chong, Ziming Wang, Haiwen Chen, Hecheng  Li, Jun Cao, Peng Zhang, Hongliang Li
Pages: 1717-1724
Published online on: 23 July 2014

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Article Open Access

Rat hepatic stellate cells alter the gene expression profile and promote the growth, migration and invasion of hepatocellular carcinoma cells

Zhi-Ming Wang, Le-Yuan Zhou, Bin-Bin Liu, Qin-An Jia, Yin-Ying Dong, Yun-Hong Xia, Sheng-Long Ye
Pages: 1725-1733
Published online on: 31 July 2014

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Article Open Access

Berberine induces apoptosis and DNA damage in MG‑63 human osteosarcoma cells

Yu Zhu, Nan Ma, Hui‑Xiang Li, Lin Tian, Yu‑Feng Ba, Bin Hao
Pages: 1734-1738
Published online on: 21 July 2014

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Article Open Access

Combined effect of nerve growth factor and brain‑derived neurotrophic factor on neuronal differentiation of neural stem cells and the potential molecular mechanisms

Feifei Liu, Aiguo Xuan, Yan Chen, Jundu Zhang, Liping Xu, Qijiang Yan, Dahong Long
Pages: 1739-1745
Published online on: 18 July 2014

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Article Open Access

Differentially expressed genes and interacting pathways in bladder cancer revealed by bioinformatic analysis

Yinzhou Shen, Xuelei Wang, Yongchao Jin, Jiasun Lu, Guangming Qiu, Xiaofei Wen
Pages: 1746-1752
Published online on: 18 July 2014

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Article Open Access

Chromogranin A cells in the stomachs of patients with sporadic irritable bowel syndrome

Magdy El-Salhy, Odd Helge Gilja, Trygve Hausken
Pages: 1753-1757
Published online on: 08 August 2014

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Article

Protective effects and mechanisms of total alkaloids of Rubus alceaefolius Poir on non‑alcoholic fatty liver disease in rats

Haiyin Zheng, Jinyan Zhao, Yuqing Zheng, Juan Wu, Yan Liu, Jun Peng, Zhenfeng Hong
Pages: 1758-1764
Published online on: 21 July 2014

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Article Open Access

Effects of high mobility group protein box 1 and toll like receptor 4 pathway on warts caused by human papillomavirus

Hui Weng, Hongbo Liu, Yunhua Deng, Yuyan Xie, Guanxin Shen
Pages: 1765-1771
Published online on: 11 August 2014

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Article Open Access

Novel mitochondrial mutations in the ATP6 and ATP8 genes in patients with breast cancer

Ludmiła Grzybowska-Szatkowska, Brygida Ślaska, Jolanta Rzymowska, Anna Brzozowska, Bolesław Floriańczyk
Pages: 1772-1778
Published online on: 08 August 2014

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Article Open Access

Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: Recruiting histone deacetylase and inhibiting activator protein 1 transcription factors

Qingqiang Shi, Jing Li, Ziqiang Feng, Lvcui Zhao, Lian Luo, Zhimei  You, Danyang Li, Jing Xia, Guowei Zuo, Dilong Chen
Pages: 1779-1785
Published online on: 18 July 2014

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Article Open Access

Targeting complement anaphylatoxin C5a receptor in hyperoxic lung injury in mice

Ying Xu, Zhe Tian, Peiyu Xie
Pages: 1786-1792
Published online on: 18 July 2014

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Article Open Access

Rifampicin improves neuronal apoptosis in LPS-stimulated co‑cultured BV2 cells through inhibition of the TLR-4 pathway

Wei Bi, Lihong Zhu, Xiuna Jing, Zhifen Zeng, Yanran Liang, Anding Xu, Jun Liu, Songhua Xiao, Lianhong Yang, Qiaoyun Shi, Li Guo, Enxiang Tao
Pages: 1793-1799
Published online on: 11 August 2014

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Article Open Access

Functional analysis of the mRNA profile of neutrophil gelatinase‑associated lipocalin overexpression in esophageal squamous cell carcinoma using multiple bioinformatic tools

Bing-Li Wu, Chun-Quan Li, Ze-Peng Du, Fei Zhou, Jian-Jun Xie, Lie‑Wei  Luo, Jian-Yi Wu, Pi-Xian Zhang, Li-Yan Xu, En-Min Li
Pages: 1800-1812
Published online on: 07 August 2014

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Article

Mesenchymal stem cells improve intestinal integrity during severe acute pancreatitis

Xiao-Huang Tu, Shao-Xiong Huang, Wen-Sheng Li, Jing-Xiang Song, Xiao-Li Yang
Pages: 1813-1820
Published online on: 05 August 2014

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Article

Inhibitory effects of Rubi Fructus extracts on hepatic steatosis development in high-fat diet-induced obese mice

Mi Kyung Nam, Hye Ran Choi, Jin Sook Cho, Soo Min Cho, Ki Chan Ha, Tae-Hyeon Kim, Hee-Young Ryu, Young-Ik Lee
Pages: 1821-1827
Published online on: 21 July 2014

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Article

Interleukin‑15: A potent adjuvant enhancing the efficacy of an autologous whole‑cell tumor vaccine against Lewis lung carcinoma

Xi Chen, Jie Ni, Hui Meng, Dandan Li, Yuquan Wei, Yan Luo, Yang Wu
Pages: 1828-1834
Published online on: 08 August 2014

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Article

A genetic pedigree analysis to identify gene mutations involved in femoral head necrosis

Lin Wang, Hehai Pan, Zhen‑An Zhu
Pages: 1835-1838
Published online on: 22 July 2014

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Article

A germline mutation in the miR‑125a coding region reduces miR‑125a expression and is associated with human gastric cancer

Hua Shang, Tao Wang, Feng Shang, Kun‑Ming Huang, Yan‑Qing Li
Pages: 1839-1844
Published online on: 04 August 2014

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Article

MacroH2A suppresses the proliferation of the B16 melanoma cell line

Shaorong Lei, Jianhong Long, Jiaguang Li
Pages: 1845-1850
Published online on: 11 August 2014

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Article

Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43

Yongwei Gu, Gang Wu, Xin Wang, Xi Wang, Yulin Wang, Congxin Huang
Pages: 1851-1856
Published online on: 30 July 2014

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Article

Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection

Yun Li, Na Li, Wei Ma, Yuanzhu Jiang, Guoyuan Ma, Lin Zhang
Pages: 1857-1862
Published online on: 01 August 2014

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Article

Effect of siRNA‑induced inhibition of IL‑6 expression in rat cerebral gliocytes on cerebral edema following traumatic brain injury

Bin Xu, Dong‑Ming Yu, Fu‑Sheng Liu
Pages: 1863-1868
Published online on: 07 August 2014

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Article

Selenium treatment significantly inhibits tumor necrosis factor‑α‑induced cell death and tau hyperphosphorylation in neuroblastoma cells

Young Ju Lee, Ji Eun Kim, Moon Hwa Kwak, Jun Go, Seung Yun Yang, Hyeog Soong Kwon, Byoung Chul Kim, Joo Man Kim, Dae Youn Hwang
Pages: 1869-1874
Published online on: 04 August 2014

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Article

Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia

Wei‑Dong Zhang, Zhan Zhang, Li‑Ting Jia, Lin‑Lin Zhang, Teng Fu, Yu‑Shan Li, Peng Wang, Lin Sun, Ying Shi, Hui‑Zhen Zhang
Pages: 1875-1880
Published online on: 29 July 2014

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Article

Neuronal nitric oxide synthase, as a downstream signaling molecule of c‑jun, regulates the survival of differentiated PC12 cells

Xiao Cheng, Haoxuan Luo, Zijun Hou, Yan Huang, Jingbo Sun, Lihua Zhou
Pages: 1881-1886
Published online on: 23 July 2014

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Article

Detection of the phosphatase activity of carbonic anhydrase III on a nitrocellulose membrane following 2D gel electrophoresis

He Huang, Hui-Min Ren, Xi-Liang Shang, Xue-Yuan Liu
Pages: 1887-1892
Published online on: 04 August 2014

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Article

Expression and significance of Pin1, β‑catenin and cyclin D1 in hepatocellular carcinoma

Ran Ao, Dao‑Rong Zhang, Ya‑Qi Du, Ying Wang
Pages: 1893-1898
Published online on: 06 August 2014

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Article

Odontogenic differentiation of vascular endothelial growth factor‑transfected human dental pulp stem cells in vitro

Wen Zhang, Wei Liu, Junqi Ling, Zhengmei Lin, Yan Gao, Xueli Mao, Yutao Jian
Pages: 1899-1906
Published online on: 11 August 2014

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Article

Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function

Ying‑Hua Xie, Nan Zhang, Lan‑Fang Li, Qin‑Zeng Zhang, Li‑Jun  Xie, Hong Jiang, Li‑Ping Li, Na Hao, Jian‑Xin Zhang
Pages: 1907-1914
Published online on: 17 July 2014

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Article

Formaldehyde induces bone marrow toxicity in mice by inhibiting peroxiredoxin 2 expression

Guangyan Yu, Qiang Chen, Xiaomei Liu, Caixia Guo, Haiying Du, Zhiwei Sun
Pages: 1915-1920
Published online on: 08 August 2014

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Article

Anthocyanins potentiate the activity of trastuzumab in human epidermal growth factor receptor 2‑positive breast cancer cells in vitro and in vivo

Weihua Liu, Jinmei Xu, Yilun Liu, Xiaoping Yu, Xi Tang, Zhi Wang, Xin Li
Pages: 1921-1926
Published online on: 22 July 2014

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Article

Raltitrexed induces mitochondrial‑mediated apoptosis in SGC7901 human gastric cancer cells

Song Xue, Ying‑Xia Chen, Shu‑Kui Qin, Ai‑Zhen Yang, Lin  Wang, Hai‑Jun Xu, Hai‑Yun Geng
Pages: 1927-1934
Published online on: 01 August 2014

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Article

Decreased osteoclastogenesis, osteoblastogenesis and low bone mass in a mouse model of type 2 diabetes

Fei Xu, Yonghui Dong, Xin Huang, Mi Li, Liang Qin, Ye Ren, Fengjing Guo, Anmin Chen, Shilong Huang
Pages: 1935-1941
Published online on: 30 July 2014

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Article

Protective effects of the p38 MAPK inhibitor SB203580 on NMDA‑induced injury in primary cerebral cortical neurons

Xue‑Wen Liu, En‑Fei Ji, Peng He, Rui‑Xian Xing, Bu‑Xian Tian, Xi‑Dong Li
Pages: 1942-1948
Published online on: 21 July 2014

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Article

Ulinastatin protects cardiomyocytes against ischemia‑reperfusion injury by regulating autophagy through mTOR activation

Jian Xiao, Xiaoyan Zhu, Guangyu Ji, Qian Yang, Bo Kang, Jianquan  Zhao, Feng Yao, Lihui Wu, Xin Ni, Zhinong Wang
Pages: 1949-1953
Published online on: 05 August 2014

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Article

Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy

Huabin Zheng, Zhuhong Zhang, Na Luo, Yuanyuan Liu, Qingzhong Chen, Hua Yan
Pages: 1954-1958
Published online on: 05 August 2014

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Article

Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79

Xiangyu Meng, Meng Li, Jun Guo, Weiqing Tang, Shu  Wang, Yong Man, Xiuqing Huang, Jian Li
Pages: 1959-1963
Published online on: 18 July 2014

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Article

Resveratrol ameliorates low shear stress‑induced oxidative stress by suppressing ERK/eNOS‑Thr495 in endothelial cells

Zhimei Wang, Junxia Zhang, Bing Li, Xiaofei Gao, Yanrong Liu, Wenxing Mao, Shao‑Liang Chen
Pages: 1964-1972
Published online on: 17 July 2014

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Article

Effect of PTEN and KAI1 gene overexpression on the proliferation, metastasis and radiosensitivity of ASPC‑1 pancreatic cancer cells under hypoxic conditions

Hongyu Li, Jianjun Li, Xu Liu, Jiang Chen, Chunyan Wu, Xiaozhong Guo
Pages: 1973-1977
Published online on: 21 July 2014

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Article

Soluble a‑proliferation‑inducing ligand (sAPRIL), a novel serum biomarker predicting the recurrence and metastasis of pancreatic adenocarcinoma after surgery

Lei Han, Wei Zhang, Fulin Song, Yang Guo, Kejian Guo, Wenping Zhou
Pages: 1978-1984
Published online on: 04 August 2014

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Article

Wnt5a is associated with the differentiation of bone marrow mesenchymal stem cells in vascular calcification by connecting with different receptors

Siming Guan, Zhimin Wang, Fang Xin, Huaping Xin
Pages: 1985-1991
Published online on: 05 August 2014

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Article

High glucose induces Rho/ROCK-dependent visfatin and type I procollagen expression in rat primary cardiac fibroblasts

Rong Yang, Liang Chang, Suyun Liu, Xin Jin, Yongjun Li
Pages: 1992-1998
Published online on: 22 July 2014

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Article

Baicalein inhibits migration and invasion of gastric cancer cells through suppression of the TGF‑β signaling pathway

Fenglin Chen, Mingkai Zhuang, Jun Peng, Xiaozhong Wang, Tingxuan Huang, Sanmei Li, Manqiang Lin, Hongming Lin, Yating Xu, Jianying Li, Zhixin Chen, Yuehong Huang
Pages: 1999-2003
Published online on: 05 August 2014

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Article

Differential expression profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases in females with or without pelvic organ prolapse

Xiaohong Wang, Yiqi Li, Jie Chen, Xiaoli Guo, Han Guan, Candong Li
Pages: 2004-2008
Published online on: 08 August 2014

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Article Open Access

Mass spectrometry-based, label-free quantitative proteomics of round spermatids in mice

Hailong Wang, Yan Li, Lijuan Yang, Baofeng Yu, Ping Yan, Min Pang, Xiaobing Li, Hong Yang, Guoping Zheng, Jun Xie, Rui Guo
Pages: 2009-2024
Published online on: 06 August 2014

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Article

Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma

Yvonne Y.Y. Or, Ariel K.M. Chow, Lui Ng, Sheung Tat Fan, Thomas  C.C. Yau, Ronnie T.P. Poon, Roberta W.C. Pang
Pages: 2025-2030
Published online on: 22 July 2014

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Article

Gleditsia sinensis thorn extract inhibits the proliferation and migration of PDGF‑induced vascular smooth muscle cells

Sung‑Soo Park, Wun‑Jae Kim, Sung‑Kwon Moon
Pages: 2031-2038
Published online on: 28 July 2014

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Article

SCN5A mutations and polymorphisms in patients with ventricular fibrillation during acute myocardial infarction

Tim Boehringer, Peter Bugert, Martin Borggrefe, Elif Elmas
Pages: 2039-2044
Published online on: 21 July 2014

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Article

Histone deacetylase 5 promotes the proliferation of glioma cells by upregulation of Notch 1

Quan Liu, Jie‑Min Zheng, Jia‑Kang Chen, Xian‑Lei Yan, Hong‑Mou Chen, Wei‑Xia Nong, He‑Qing Huang
Pages: 2045-2050
Published online on: 18 July 2014

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Article

Protective effect of proanthocyanidins on anoxia-reoxygenation injury of myocardial cells mediated by the PI3K/Akt/GSK-3β pathway and mitochondrial ATP-sensitive potassium channel

Yanyan Hu, Li Li, Wenbin Yin, Lin Shen, Beian You, Haiqing Gao
Pages: 2051-2058
Published online on: 06 August 2014

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Article

Expression of programmed cell death 5 protein inhibits progression of lung carcinoma in vitro and in vivo via the mitochondrial apoptotic pathway

Shining Xu, Gang Sui, Lei Yuan, Zhiqiang Zou
Pages: 2059-2064
Published online on: 05 August 2014

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Article

Effect and mechanism of Src tyrosine kinase inhibitor sunitinib on the drug-resistance reversal of human A549/DDP cisplatin-resistant lung cancer cell line

Ke Zhang, Xian Wang, Hongyan Wang
Pages: 2065-2072
Published online on: 04 August 2014

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Article

High glucose reduces hepatic glycogenesis by suppression of microRNA‑152

Xiaoyun Zhao, Yonggang Lu, Fenghong Wang, Lin Dou, Lilin Wang, Jun Guo, Jian Li
Pages: 2073-2078
Published online on: 28 July 2014

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Article

microRNA response element‑regulated TIKI2 expression suppresses the tumorigencity of malignant gliomas

Chuan‑You Li, Hong‑Yun Zhang, Yi‑Lu Gao
Pages: 2079-2086
Published online on: 22 July 2014

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Article

Suppressed Krüppel‑like factor 17 expression induces tumor proliferation, metastasis and a poor prognosis in papillary thyroid carcinoma

Wen‑Chun Ye, Li Gao, Jing Huang, Xiang‑Ming Fang, Gang Xie
Pages: 2087-2092
Published online on: 29 July 2014

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Article

Celecoxib induces apoptosis via a mitochondria‑dependent pathway in the H22 mouse hepatoma cell line

Dan Shao, Mujie Kan, Ping Qiao, Yue Pan, Zheng Wang, Xuanang Xiao, Jing Li, Li Chen
Pages: 2093-2098
Published online on: 07 August 2014

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miR‑210 regulates esophageal cancer cell proliferation by inducing G2/M phase cell cycle arrest through targeting PLK1

Chenglin Li, Xinliang Zhou, Yadi Wang, Shaowu Jing, Congrong Yang, Guogui Sun, Qing Liu, Yunjie Cheng, Lan Wang
Pages: 2099-2104
Published online on: 23 July 2014

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Inhibition of the interleukin‑23/interleukin‑17 pathway by anti‑interleukin‑23p19 monoclonal antibody attenuates 2,4,6‑trinitrobenzene sulfonic acid‑induced Crohn's disease in rats

Jia Yin Yao, Yi Lu, Min Zhi, Chu Jun Li, Pin Jin Hu, Xiang Gao
Pages: 2105-2110
Published online on: 28 July 2014

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1α,25-Dihydroxyvitamin D3 enhances γ-glutamyl transpeptidase activity in LLC-PK1 porcine kidney epithelial cells

Ritsu Ito, Hideyuki Ihara, Takahiro Okada, Yoshitaka Ikeda
Pages: 2111-2115
Published online on: 31 July 2014

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Administration of a plasmid that expresses SDF-1α affects the oncogenic potential of mouse bcr-abl-transformed cells

Vincent Lucansky, Monika Krmencikova-Fliegl, Libor Stanek, Vladimir Vonka
Pages: 2116-2122
Published online on: 28 July 2014

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Helicobacter pylori promotes VEGF expression via the p38 MAPK‑mediated COX‑2‑PGE2 pathway in MKN45 cells

Ningning Liu, Qiong Wu, Yan Wang, Hua Sui, Xuan Liu, Ning Zhou, Lihong Zhou, Yifei Wang, Naijing Ye, Xiaoling Fu, Nikitin Alexander Yu, Qi Li
Pages: 2123-2129
Published online on: 06 August 2014

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In silico prediction of the T‑cell and IgE‑binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches

Hao Chen, Hai‑Wei Yang, Ji‑Fu Wei, Ai‑Lin Tao
Pages: 2130-2136
Published online on: 21 July 2014

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Rosiglitazone suppresses angiogenesis in multiple myeloma via downregulation of hypoxia‑inducible factor‑1α and insulin‑like growth factor‑1 mRNA expression

Mingzhong Rui, Zhanping Huang, Ying Liu, Ziyan Wang, Rui Liu, Jinxiang Fu, Haiwen Huang
Pages: 2137-2143
Published online on: 22 July 2014

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Dichloroacetate prevents but not reverses the formation of neointimal lesions in a rat model of severe pulmonary arterial hypertension

Bingbing Li, Jie Yan, Yan Shen, Yong Liu, Zhengliang Ma
Pages: 2144-2152
Published online on: 30 July 2014

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Kanglaite stimulates anticancer immune responses and inhibits HepG2 cell transplantation‑induced tumor growth

Xinli Huang, Jianjie Qin, Sen Lu
Pages: 2153-2159
Published online on: 11 August 2014

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MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1

Fei Wang, Ji-Yong Sun, You‑Hou Zhu, Ning-Tao Liu, Yi-Fang Wu, Fei Yu
Pages: 2160-2164
Published online on: 28 July 2014

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Involvement of connexin43 in the acute hyperosmotic stimulus‑induced synthesis and release of vasopressin in the supraoptic nucleus of rats

Shan Jiang, Yong‑Qiang Wang, Cheng‑Feng Xu, Ya‑Na Li, Rong Guo, Ling Li
Pages: 2165-2171
Published online on: 21 July 2014

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HSP60 is involved in the neuroprotective effects of naloxone

Wenjing Cheng, Yunhong Li, Xiaolin Hou, Nan Zhang, Jiao  Ma, Feijia Ding, Fan Li, Zhenhua Miao, Yanli Zhang, Qi Qi, Guanghua  Li, Ying Shen, Juan Liu, Weidong Huang, Yin Wang
Pages: 2172-2176
Published online on: 22 July 2014

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CCAAT/enhancer‑binding protein β regulates interleukin‑6‑induced transmembrane and ubiquitin‑like domain containing 1 gene expression in hepatocytes

Menggang Liu, Tao Yuan, Hongming Liu, Ping Chen
Pages: 2177-2183
Published online on: 06 August 2014

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Article

Continuous hypoxia regulates the osteogenic potential of mesenchymal stem cells in a time-dependent manner

Hao Ding, Song Chen, Jun-Hui Yin, Xue-Tao Xie, Zhen‑Hong  Zhu, You-Shui Gao, Chang-Qing Zhang
Pages: 2184-2190
Published online on: 05 August 2014

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Article

Visceral adipose tissue‑derived serine protease inhibitor inhibits interleukin‑1β‑induced catabolic and inflammatory responses in murine chondrocytes

Jia‑Peng Bao, Li‑Feng Jiang, Jing Li, Wei‑Ping Chen, Peng‑Fei Hu, Li‑Dong Wu
Pages: 2191-2197
Published online on: 11 August 2014

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Synergistic effect of celecoxib in tumor necrosis factor‑related apoptosis‑inducing ligand treatment in osteosarcoma cells

Gong Liu, Ming-Yang Yu, Xu Huang, Dong Zhu, Shihuan Cheng, Renshi Ma, Guishan Gu
Pages: 2198-2202
Published online on: 22 July 2014

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Enforced expression of miR‑101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase‑2 pathway

Qiang Bu, Yue Fang, Yuan Cao, Qiaoyun Chen, Yangchen Liu
Pages: 2203-2209
Published online on: 06 August 2014

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Microarray analysis of long non-coding RNA expression in human acute rejection biopsy samples following renal transplantation

Wenbiao Chen, Wujian Peng, Jianrong Huang, Xiangqi Yu, Kuibi Tan, Yuyu Chen, Xiaocong Lin, Deheng Chen, Yong Dai
Pages: 2210-2216
Published online on: 24 July 2014

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October-2026 Volume 34 Issue 4

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression

Shuangxi Tu, Xiaodan Wang, Zhenbo Wang, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 296
Published online on: 03 September 2026

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Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review)

Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima
Article Number: 295
Published online on: 03 September 2026

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From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review)

Yuying Li, Ling Wei, Fang Sun, Huixia Wu, Xijun Sun, Yirong Gan, Xiaohua Kong
Article Number: 294
Published online on: 03 September 2026

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Resurrection biology: Melatonin as a modulator of anastasis (Review)

Alexandros Georgiou, Russel J. Reiter, Vassilis Zoumpourlis, Demetrios A. Spandidos
Article Number: 293
Published online on: 02 September 2026

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[Corrigendum] CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Qianle Yu, Kai Gao
Article Number: 292
Published online on: 01 September 2026

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Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review)

Xiufen Zhong, Jingtao Gui
Article Number: 291
Published online on: 28 August 2026

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Article Open Access

POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy

Yongbo Ma, Xiaozhe Chen, Zixian Liu, Yulong Ma, Chunlei Hou, Yunfeng Li, Mingtai Gui, Bo Lu, Deyu Fu, Mingzhu Wang
Article Number: 290
Published online on: 26 August 2026

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[Corrigendum] Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Article Number: 289
Published online on: 24 August 2026

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Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review)

Laifeng Wu, Lingchen Liao, Ziwei Xia, Qiao Zeng, An Huang, Zhiyong Cao
Article Number: 288
Published online on: 21 August 2026

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Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review)

Xi Wang, Baojun Duan, Jun Bai, Huitong Liu
Article Number: 287
Published online on: 20 August 2026

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Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review)

Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li
Article Number: 286
Published online on: 20 August 2026

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Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis

Junjian Chen, Wanyi Zhang, Tao Hong, Junsheng Wang, Chuan Chen, Ying Zhang, Mi Hu, Ning You, Jietao Huang
Article Number: 285
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons 

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu
Article Number: 284
Published online on: 20 August 2026

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Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review)

Qianqian Li, Yufang Ni, Zhaoyang Li, Jianchun Li, Li Wang
Article Number: 283
Published online on: 18 August 2026

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Biological mechanisms of atropine in myopia control (Review)

Qin Zhu, Guanglong Zhou, Lingguo Wang, Xuejiao Li, Zhijuan Hua, Jie Yin, Jieying Zhang, Yuan Zhou, Xiaofan Zhang, Allison Wilde, Yingting Zhu, Liping Xue
Article Number: 282
Published online on: 18 August 2026

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6'‑O‑Caffeoylarbutin attenuates experimental hyperuricemia by regulating renal and intestinal urate transport, intestinal barrier integrity, and gut microbiota

Xuezhi Yu, Yang Zhang, Konchun Sun, Rui Yang, Xingde Li, Xiuzhen Chen, Tiantian Li, Xiaolei Yang, Ming Li, Lu Liu, Fei Li, Baochun Shen
Article Number: 281
Published online on: 18 August 2026

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Retraction Open Access

[Retracted] Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival  

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Article Number: 280
Published online on: 17 August 2026

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Uric acid enhances tumor stemness in breast cancer cells by upregulating GMPS

Zhiying Wang, Mingzhang Huang, Yuanqi Zhang, Siqi Huang, Wei Lei, Xiaorong Shui
Article Number: 279
Published online on: 13 August 2026

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Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis

Le-Yi Huang, Yao Chen, Lin-Ran Song, Zhuo-Lin Zhong, Kamran Ali, Hui-Min Li, Qing-Feng Hu, Hong-Hua Hu
Article Number: 278
Published online on: 13 August 2026

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Expression of Concern Open Access

[Expression of Concern] MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells

Shufang He, Guiyuan Yu, Ke Peng, Sisun Liu
Article Number: 277
Published online on: 12 August 2026

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Review

Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review)

Shaoying An, Wenhui Sun, Lizhou Shi, Hai Chen, Zhongcheng Mo
Article Number: 276
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis

Liang Hao, Yuying Wan, Juhua Xiao, Qiang Tang, Huan Deng, Lu Chen
Article Number: 275
Published online on: 10 August 2026

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Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu
Article Number: 274
Published online on: 06 August 2026

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Mitochondrial quality control in acute liver injury and its therapeutic implications (Review)

Ziqiang Chen, Yunhe Wang, Yijing Li, Gang Cong, Yunhang Chu, Yunhui Bai, Yishuo Zhang, Liya Zhou
Article Number: 273
Published online on: 05 August 2026

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STC1 promotes osteogenic differentiation and represses inflammation via inhibition of NF‑κB signaling in mesenchymal stromal cells

Chen Yang, Xin Li, Peng Wang, Yitong Chen, Erli Wu, Qian Chen, Jing Hu, Fu Zheng, Lamu Gongsang, Jiayu Li, Mengyuan Zhang, Jing Zhou, Bing Han, Amr A. Badreldin, Yuka Miyamoto, Jin Koo Kim, Insoon Chang, Jia Chang, Paul H. Krebsbach, Liyuan Huang, Xiaoping Xu, Xiaoyan Chen, Peng Deng, Qianming Chen, Lijie Fan
Article Number: 272
Published online on: 05 August 2026

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Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review)

Teng Sun, Lei Ye
Article Number: 271
Published online on: 04 August 2026

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Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review)

Fengyun Gao, Lili Wang, Guiyun Teng, Liqiong Shang
Article Number: 270
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Article Number: 269
Published online on: 03 August 2026

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Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review)

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu
Article Number: 268
Published online on: 31 July 2026

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Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review)

Liqi Zhang, Shuxia Yang, Huiyan Wu, Hong Zhou
Article Number: 267
Published online on: 30 July 2026

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Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

Rongtou Huang, Danning Mo, Huitian Huang, Minmin Zhang, Wenhong Yu, Buqing Cao
Article Number: 266
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses

Yubo Xiao, Min Feng, Haiying Ran, Xiao Han, Xuegang Li
Article Number: 265
Published online on: 29 July 2026

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Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review)

Xiaona Wang, Hua Du, Yingxu Shi
Article Number: 264
Published online on: 28 July 2026

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Association between periodontitis and heart failure: Mechanisms and clinical implications (Review)

Xinyue Zhang, Xiaoli An
Article Number: 263
Published online on: 28 July 2026

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Article Open Access

Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene CLOCK

Jiawen Yu, Chunmei Qian, Renye Que, Yi Zhou
Article Number: 262
Published online on: 28 July 2026

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Retraction Open Access

[Retracted] PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 261
Published online on: 27 July 2026

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UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analyses

Yun Wen, Pengfei Luo
Article Number: 260
Published online on: 23 July 2026

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Journal Cover
November-2026 Volume 34 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review)

Yuwen Zeng, Yutong Yan, Shiye Wu, Wanshan Wu, Ke Chen, Youyi Lai, Qing Ye, Nan Zhang, Yuanyuan Zhou
Article Number: 320
Published online on: 23 September 2026

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Lactylation in gastric cancer: From mechanisms to clinical applications (Review)

Yuliang Fang, Peng Chen, Yuhong Gao, Yanpiao Li, Xue Li
Article Number: 319
Published online on: 23 September 2026

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Article Open Access

Sleep deprivation exacerbates lens‑induced myopia in association with ERK/NF‑κB pathway activation

Xueli Yang, Zhou Zhang, Chengbai Zhu, Jianbo Li, Wenting Gong, Ruirui Yang, Lipeng Guan
Article Number: 318
Published online on: 22 September 2026

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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Article Open Access

High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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Retraction Open Access

[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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Article Open Access

A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Article Open Access

Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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Retraction Open Access

[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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Article Open Access

KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Review Open Access

Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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