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A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells

  • Authors:
    • Jianping Li
    • Tie Chong
    • Ziming Wang
    • Haiwen Chen
    • Hecheng  Li
    • Jun Cao
    • Peng Zhang
    • Hongliang Li
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1717-1724
    |
    Published online on: July 23, 2014
       https://doi.org/10.3892/mmr.2014.2417
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Abstract

Carcinoma progression is associated with the loss of epithelial features and the acquisition of a mesenchymal phenotype, a process known as epithelial‑mesenchymal transition (EMT). Resveratrol, a natural polyphenolic compound found in grapes, berries and peanuts, has a wide range of pharmacological properties, including anti‑tumor metastasis properties. The underlying mechanism through which resveratrol inhibits metastasis of prostate cancer (PCa) is not yet fully understood; however, it is thought to be associated with the disruption of EMT. In the present study, lipopolysaccharide (LPS) was used to trigger EMT in PC‑3 and LNCaP PCa cell lines, and the cell lines were subsequently treated with resveratrol. The results demonstrated that exposure of PC‑3 and LNCaP cells to LPS resulted in morphological alterations characteristic of EMT, as well as an increase in the expression of the mesenchymal marker vimentin and a decrease in the expression of E‑cadherin. In addition, LPS exposure resulted in an increase in cell motility, along with an upregulation of the transcription factor glioma‑associated oncogene homolog 1 (Gli1). However, treatment with resveratrol inhibited LPS‑induced morphological changes, decreased the expression of LPS‑induced markers of EMT and inhibited the expression of Gli1, resulting in the inhibition of in vitro cell motility and invasiveness. These results provide a novel perspective for the anti‑invasion mechanism of resveratrol, suggesting that the effect is in part due to its ability to inhibit the EMT process through the Hedgehog signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Chong T, Wang Z, Chen H, Li H, Cao J, Zhang P and Li H: A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells. Mol Med Rep 10: 1717-1724, 2014.
APA
Li, J., Chong, T., Wang, Z., Chen, H., Li, H., Cao, J. ... Li, H. (2014). A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells. Molecular Medicine Reports, 10, 1717-1724. https://doi.org/10.3892/mmr.2014.2417
MLA
Li, J., Chong, T., Wang, Z., Chen, H., Li, H., Cao, J., Zhang, P., Li, H."A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells". Molecular Medicine Reports 10.4 (2014): 1717-1724.
Chicago
Li, J., Chong, T., Wang, Z., Chen, H., Li, H., Cao, J., Zhang, P., Li, H."A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells". Molecular Medicine Reports 10, no. 4 (2014): 1717-1724. https://doi.org/10.3892/mmr.2014.2417
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Chong T, Wang Z, Chen H, Li H, Cao J, Zhang P and Li H: A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells. Mol Med Rep 10: 1717-1724, 2014.
APA
Li, J., Chong, T., Wang, Z., Chen, H., Li, H., Cao, J. ... Li, H. (2014). A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells. Molecular Medicine Reports, 10, 1717-1724. https://doi.org/10.3892/mmr.2014.2417
MLA
Li, J., Chong, T., Wang, Z., Chen, H., Li, H., Cao, J., Zhang, P., Li, H."A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells". Molecular Medicine Reports 10.4 (2014): 1717-1724.
Chicago
Li, J., Chong, T., Wang, Z., Chen, H., Li, H., Cao, J., Zhang, P., Li, H."A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cells". Molecular Medicine Reports 10, no. 4 (2014): 1717-1724. https://doi.org/10.3892/mmr.2014.2417
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