Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October 2014 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2014 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection

  • Authors:
    • Yun Li
    • Na Li
    • Wei Ma
    • Yuanzhu Jiang
    • Guoyuan Ma
    • Lin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Urology, Shandong Zhangqiu People's Hospital, Jinan, Shandong 250200, P.R. China
  • Pages: 1857-1862
    |
    Published online on: August 1, 2014
       https://doi.org/10.3892/mmr.2014.2437
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Thoracic aortic dissection (TAD) is a life‑threatening vascular condition, in which matrix metalloproteinases (MMPs) are involved. Since the key determinants underlying MMP action remain elusive, the present study investigated the correlation between single nucleotide polymorphisms (SNPs) in the promoter region of the MMP‑8 gene and a predisposition to TAD, by comparing genotypes of TAD patients and healthy controls. From 154 TAD patients and 148 healthy individuals, DNA samples were obtained from venous blood, and genotyping was performed by a combination of polymerase chain reaction and automatic sequencing to detect SNPs in the MMP‑8 promoter. Data were analyzed and odds ratios (OR) and 95% confidence intervals (CI) were calculated. P<0.05 was considered to indicate a statistically significant result. Two SNPs, ‑799C/T and ‑767A/T, were identified in the MMP‑8 promoter. Distribution of the ‑767A/T genotype was not significantly different between the patients and healthy controls. The ‑799C/C genotype was utilized as a match control, and significant differences in the genotypic distribution were observed between the patients with TAD and the controls. Furthermore, it was identified that the distribution of the ‑799C/T+T/T and ‑799C/C genotypes between the TAD and control populations was significantly different. The frequency of T allele distribution was higher in the TAD group (27%) than in the control group (13.5%). The genotype distribution followed the Hardy‑Weinberg equilibrium. In the present study, it was concluded that the ‑799C/T polymorphism in the promoter region of MMP‑8 may be associated with the development of TAD and that the T allele may increase patient predisposition to the disease.
View Figures

Figure 1

Figure 2

View References

1 

Jones GT, Phillips VL, Harris EL, Rossaak JI and van Rij AM: Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. J Vasc Surg. 38:1363–1367. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Mizuguchi T, Collod-Beroud G, Akiyama T, Abifadel M, Harada N, Morisaki T, Allard D, Varret M, Claustres M, Morisaki H, et al: Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet. 36:855–860. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Schwarze U, Schievink WI, Petty E, Jaff MR, Babovic-Vuksanovic D, Cherry KJ, Pepin M and Byers PH: Haploinsufficiency for one COL3A1 allele of type III procollagen results in a phenotype similar to the vascular form of Ehlers-Danlos syndrome, Ehlers-Danlos syndrome type IV. Am J Hum Genet. 69:989–1001. 2001. View Article : Google Scholar

4 

Deguara J, Burnand KG, Berg J, et al: An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms. Hum Mol Genet. 16:3002–3007. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Jones GT, Phillips VL, Harris EL, Rossaak JI and van Rij AM: Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. J Vasc Surg. 38:1363–1367. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Biddinger A, Rocklin M, Coselli J and Milewicz DM: Familial thoracic aortic dilatations and dissections: a case control study. J Vasc Surg. 25:506–511. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Chen L, Wang X, Carter SA, Shen YH, Bartsch HR, Thompson W, Coselli JS, Wilcken DL, Wang XL and LeMaire SA: A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (−8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection. J Thorac Cardiovasc Surg. 131:1045–1052. 2006.

8 

Barbour JR, Spinale FG and Ikonomidis JS: Proteinase systems and thoracic aortic aneurysm progression. J Surg Res. 139:292–307. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Hasham SN, Willing MC, Guo DC, Muilenburg A, He R, Tran VT, Scherer SE, Shete SS and Milewicz DM: Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24–25. Circulation. 107:3184–3190. 2003.PubMed/NCBI

10 

Ikonomidis JS, Barbour JR, Amani Z, Stroud RE, Herron AR, McClister DM Jr, Camens SE, Lindsey ML, Mukherjee R and Spinale FG: Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms. Circulation. 112(Suppl): I242–248. 2005.PubMed/NCBI

11 

Ishii T and Asuwa N: Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection. Hum Pathol. 31:640–646. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Sangiorgi G, Trimarchi S, Mauriello A, Righini P, Bossone E, Suzuki T, Rampoldi V and Eagle KA: Plasma levels of metalloproteinases-9 and -2 in the acute and subacute phases of type A and type B aortic dissection. J Cardiovasc Med (Hagerstown). 7:307–315. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Wilson WR, Anderton M, Schwalbe EC, Jones JL, Furness PN, Bell PR and Thompson MM: Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture. Circulation. 113:438–445. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Zhang B, Ye S, Herrmann SM, Eriksson P, de Maat M, Evans A, Arveiler D, Luc G, Cambien F, Hamsten A, et al: Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation. 99:1788–1794. 1999. View Article : Google Scholar : PubMed/NCBI

15 

González-Arriaga P, López-Cima MF, Fernández-Somoano A, Pascual T, Marrón MG, Puente XS and Tardón A: Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk. BMC Cancer. 8:3782008.PubMed/NCBI

16 

Wagner S, Kluge B, Koziol JA, Grau AJ and Grond-Ginsbach C: MMP-9 polymorphisms are not associated with spontaneous cervical artery dissection. Stroke. 35:e62–64. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Lamblin N, Bauters C, Hermant X, Lablanche JM, Helbecque N and Amouyel P: Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease. J Am Coll Cardiol. 40:43–48. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Daily PO, Trueblood HW, Stinson EB, Wuerflein RD and Shumway NE: Management of acute aortic dissections. Ann Thorac Surg. 10:237–247. 1970. View Article : Google Scholar : PubMed/NCBI

19 

Allaire E, Hasenstab D, Kenagy RD, Starcher B, Clowes MM and Clowes AW: Prevention of aneurysm development and rupture by local overexpression of plasminogen activator inhibitor-1. Circulation. 98:249–255. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Barbour JR, Spinale FG and Ikonomidis JS: Proteinase systems and thoracic aortic aneurysm progression. J Surg Res. 139:292–307. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Li Y, Shao AZ, Jiang HT, Dong GH, Xu B, Yi J and Jing H: The prominent expression of plasma matrix metalloproteinase-8 in acute thoracic aortic dissection. J Surg Res. 163:e99–104. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Noirey N, Staquet MJ, Gariazzo MJ, Serres M, André C, Schmitt D and Vincent C: Relationship between expression of matrix metalloproteinases and migration of epidermal and in vitro generated Langerhans cells. Eur J Cell Biol. 81:383–389. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, et al: Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). Hum Mol Genet. 13:2659–2669. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Fleck TM, Koinig H, Czerny M, Hutschala D, Wolner E, Ehrlich M and Grabenwoger M: Impact of surgical era on outcomes of patients undergoing elective atherosclerotic ascending aortic aneurysm operations. Eur J Cardiothorac Surg. 26:342–347. 2004. View Article : Google Scholar

25 

Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A and Engler JA: Matrix metalloproteinases: a review. Crit Rev Oral Biol Med. 4:197–250. 1993.PubMed/NCBI

26 

Medley TL, Cole TJ, Dart AM, Gatzka CD and Kingwell BA: Matrix metalloproteinase-9 genotype influences large artery stiffness through effects on aortic gene and protein expression. Arterioscler Thromb Vasc Biol. 24:1479–1484. 2004. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Li N, Ma W, Jiang Y, Ma G and Zhang L: Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection. Mol Med Rep 10: 1857-1862, 2014.
APA
Li, Y., Li, N., Ma, W., Jiang, Y., Ma, G., & Zhang, L. (2014). Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection. Molecular Medicine Reports, 10, 1857-1862. https://doi.org/10.3892/mmr.2014.2437
MLA
Li, Y., Li, N., Ma, W., Jiang, Y., Ma, G., Zhang, L."Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection". Molecular Medicine Reports 10.4 (2014): 1857-1862.
Chicago
Li, Y., Li, N., Ma, W., Jiang, Y., Ma, G., Zhang, L."Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection". Molecular Medicine Reports 10, no. 4 (2014): 1857-1862. https://doi.org/10.3892/mmr.2014.2437
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Li N, Ma W, Jiang Y, Ma G and Zhang L: Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection. Mol Med Rep 10: 1857-1862, 2014.
APA
Li, Y., Li, N., Ma, W., Jiang, Y., Ma, G., & Zhang, L. (2014). Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection. Molecular Medicine Reports, 10, 1857-1862. https://doi.org/10.3892/mmr.2014.2437
MLA
Li, Y., Li, N., Ma, W., Jiang, Y., Ma, G., Zhang, L."Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection". Molecular Medicine Reports 10.4 (2014): 1857-1862.
Chicago
Li, Y., Li, N., Ma, W., Jiang, Y., Ma, G., Zhang, L."Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection". Molecular Medicine Reports 10, no. 4 (2014): 1857-1862. https://doi.org/10.3892/mmr.2014.2437
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team