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Article

Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy

  • Authors:
    • Huabin Zheng
    • Zhuhong Zhang
    • Na Luo
    • Yuanyuan Liu
    • Qingzhong Chen
    • Hua Yan
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Immunology, School of Medicine, Nankai University, Tianjin 300071, P.R. China
  • Pages: 1954-1958
    |
    Published online on: August 5, 2014
       https://doi.org/10.3892/mmr.2014.2448
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Abstract

T helper 17 (Th17) cells are strong inducers of numerous autoimmune diseases and inflammation. However, the role of Th17 cells and interleukin (IL)‑17 in traumatic optic neuropathy (TON) are yet to be elucidated. In the present study, a rat model of TON was established using a fluid percussion brain injury device. Th17 cells were found to be upregulated in the spleens of rats in the TON group. In addition, the level of IL‑17 in the retina of rats in the TON group was observed to increase with the upregulation of the Th17 cells. Furthermore, the expression of IL‑17 in the optic nerve was found to be upregulated between one and seven days following injury in the rats in the TON group. These findings strongly suggest that the ratio of Th17 cells and the expression of IL‑17 are upregulated in rats with TON. These findings also provide a rationale for developing therapeutic agents to treat TON.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng H, Zhang Z, Luo N, Liu Y, Chen Q and Yan H: Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy. Mol Med Rep 10: 1954-1958, 2014.
APA
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., & Yan, H. (2014). Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy. Molecular Medicine Reports, 10, 1954-1958. https://doi.org/10.3892/mmr.2014.2448
MLA
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., Yan, H."Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy". Molecular Medicine Reports 10.4 (2014): 1954-1958.
Chicago
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., Yan, H."Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy". Molecular Medicine Reports 10, no. 4 (2014): 1954-1958. https://doi.org/10.3892/mmr.2014.2448
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng H, Zhang Z, Luo N, Liu Y, Chen Q and Yan H: Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy. Mol Med Rep 10: 1954-1958, 2014.
APA
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., & Yan, H. (2014). Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy. Molecular Medicine Reports, 10, 1954-1958. https://doi.org/10.3892/mmr.2014.2448
MLA
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., Yan, H."Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy". Molecular Medicine Reports 10.4 (2014): 1954-1958.
Chicago
Zheng, H., Zhang, Z., Luo, N., Liu, Y., Chen, Q., Yan, H."Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy". Molecular Medicine Reports 10, no. 4 (2014): 1954-1958. https://doi.org/10.3892/mmr.2014.2448
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