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Article

Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study

  • Authors:
    • Renhong He
    • Jianzhong Fan
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 2427-2432
    |
    Published online on: August 21, 2014
       https://doi.org/10.3892/mmr.2014.2508
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Abstract

Poor viability of transplanted bone marrow mesenchymal stem cells (BMSCs) is well‑known, but developing methods for enhancing the viability of BMSCs requires further investigation. The aim of the present study was to elucidate the effects of infrasound on the proliferation and apoptosis of BMSCs, and to determine the association between survivin expression levels and infrasound on BMSCs. Primary BMSCs were derived from Sprague Dawley rats. The BMSCs, used at passage three, were divided into groups that received infrasound for 10, 30, 60, 90 or 120 min, and control groups, which were exposed to the air for the same durations. Infrasound was found to promote proliferation and inhibit apoptosis in BMSCs. The results indicated that 60 min was the most suitable duration for applied infrasound treatment to BMSCs. The protein and mRNA expression levels of survivin in BMSCs from the two treatment groups that received 60 min infrasound or air, were examined by immunofluorescence and quantitative polymerase chain reaction. Significant differences in survivin expression levels were identified between the two groups, as infrasound enhanced the expression levels of survivin. In conclusion, infrasound promoted proliferation and inhibited apoptosis in BMSCs, and one mechanisms responsible for the protective effects may be the increased expression levels of survivin.
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Copy and paste a formatted citation
Spandidos Publications style
He R and Fan J: Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study. Mol Med Rep 10: 2427-2432, 2014.
APA
He, R., & Fan, J. (2014). Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study. Molecular Medicine Reports, 10, 2427-2432. https://doi.org/10.3892/mmr.2014.2508
MLA
He, R., Fan, J."Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study". Molecular Medicine Reports 10.5 (2014): 2427-2432.
Chicago
He, R., Fan, J."Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study". Molecular Medicine Reports 10, no. 5 (2014): 2427-2432. https://doi.org/10.3892/mmr.2014.2508
Copy and paste a formatted citation
x
Spandidos Publications style
He R and Fan J: Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study. Mol Med Rep 10: 2427-2432, 2014.
APA
He, R., & Fan, J. (2014). Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study. Molecular Medicine Reports, 10, 2427-2432. https://doi.org/10.3892/mmr.2014.2508
MLA
He, R., Fan, J."Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study". Molecular Medicine Reports 10.5 (2014): 2427-2432.
Chicago
He, R., Fan, J."Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study". Molecular Medicine Reports 10, no. 5 (2014): 2427-2432. https://doi.org/10.3892/mmr.2014.2508
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