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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2014 Volume 10 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Inflammatory response in Parkinson's disease (Review)

Junqiang Yan, Qizhi Fu, Liniu Cheng, Mingming Zhai, Wenjuan Wu, Lina Huang, Ganqin Du
Pages: 2223-2233
Published online on: 12 September 2014

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Review

ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)

Shahzad Khan, Chang Hua Wang
Pages: 2234-2240
Published online on: 03 September 2014

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Review

Research progress on the central mechanism underlying regulation of visceral biological rhythm by per2 (Review)

Liting Zhu, Jun Yu, Wenyi Zhang, Bin Xie, Yi Zhu
Pages: 2241-2248
Published online on: 11 September 2014

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Article Open Access

Effects of lentiviral infection of mesenchymal stem cells on the expression of octamer transcription factor 4

Jing Chang, Li Tang, Han Lei, Xiao-Gang Zhang, Zhong Zuo, Wei Huang, Hang Fu
Pages: 2249-2254
Published online on: 21 August 2014

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Article Open Access

Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model

Zeyu Zhang, Dan Liu, Bo Yi, Zhangping Liao, Lei Tang, Dong Yin, Ming He
Pages: 2255-2262
Published online on: 05 September 2014

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Article Open Access

Alterations in the expression of vascular endothelial growth factor in the rat brain following gamma knife surgery

Lei Cheng, Lin Ma, Hecheng Ren, Hongwei Zhao, Yiqiang  Pang, Yongheng Wang, Ming Wei
Pages: 2263-2270
Published online on: 27 August 2014

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Article Open Access

1‑calcium phosphate‑uracil, a synthesized pyrimidine derivative agent, has anti‑proliferative, pro‑apoptotic and anti‑invasion effects on multiple tumor cell lines

Jing Peng, Xinlian Chen, Qian Hu, Mei Yang, Hongqian  Liu, Wei Wei, Shanling Liu, He Wang
Pages: 2271-2278
Published online on: 14 August 2014

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Article Open Access

Death receptor 5 expression IS inversely correlated WITH prostate cancer progression Corrigendum in /10.3892/mco.2017.7234

Angeles Hernandez‑Cueto, Daniel Hernandez‑Cueto, Gabriela Antonio‑Andres, Marisela Mendoza‑Marin, Carlos Jimenez‑Gutierrez, Ana Lilia Sandoval‑Mejia, Rosario Mora‑Campos, Cesar Gonzalez‑Bonilla, Mario I. Vega, Benjamin Bonavida, Sara Huerta‑Yepez
Pages: 2279-2286
Published online on: 21 August 2014

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Article Open Access

Milk thistle seed extract protects rat C6 astroglial cells from acute cocaine toxicity

Ramesh B. Badisa, Cheryl A. Fitch-Pye, Maryam Agharahimi, Donald E. Palm, Lekan M. Latinwo, Carl B. Goodman
Pages: 2287-2292
Published online on: 28 August 2014

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Article Open Access

Secreted frizzled‑related protein 2 is epigenetically silenced and functions as a tumor suppressor in oral squamous cell carcinoma

Can Xiao, Lili Wang, Lifang Zhu, Chenping Zhang, Jianhua Zhou
Pages: 2293-2298
Published online on: 05 September 2014

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Article Open Access

Effect of bone marrow stromal cell transplantation on neurologic function and expression of VEGF in rats with focal cerebral ischemia

Nan Li, Ping Wang, Xue-Ling Ma, Juan Wang, Li-Jing Zhao, Li Du, Li-Ya Wang, Xin-Rui Wang, Kang-Ding Liu
Pages: 2299-2305
Published online on: 20 August 2014

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Article Open Access

Critical role of insulin‑like growth factor binding protein‑5 in methamphetamine‑induced apoptosis in cardiomyocytes

Ka‑Pui Leung, Yi‑Hong Qu, Dong‑Fang Qiao, Wei‑Bing Xie, Dong‑Ri Li, Jing‑Tao Xu, Hui‑Jun Wang, Xia  Yue
Pages: 2306-2312
Published online on: 16 September 2014

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Article Open Access

Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression

Shulian Li, Wanli Ma, Teng Fei, Qiang Lou, Yaqin Zhang, Xiukun  Cui, Xiaoming Qin, Jun  Zhang, Guangchao Liu, Zheng Dong, Yuanfang Ma, Zhengshun Song, Yanzhong Hu
Pages: 2313-2321
Published online on: 08 September 2014

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Article Open Access

Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome

Tarek Mazzawi, Doris Gundersen, Trygve Hausken, Magdy El‑Salhy
Pages: 2322-2336
Published online on: 18 August 2014

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Article

Suppression of scinderin modulates epithelial‑mesenchymal transition markers in highly metastatic gastric cancer cell line SGC‑7901

Xiao‑Min Chen, Jun‑Ming Guo, Ping Chen, Lian‑Gang Mao, Wei‑Yun Feng, Dong‑Hai Le, Ke‑Qiang Li
Pages: 2327-2333
Published online on: 28 August 2014

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Article Open Access

Opposite effects of cefoperazone and ceftazidime on S‑ribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate

Hui-Qing Shi, Feng-Jun Sun, Jian-Hong Chen, Xiao-Lan Yong, Qian-Yi Ou, Wei Feng, Pei-Yuan Xia
Pages: 2334-2340
Published online on: 05 September 2014

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Article Open Access

Antibacterial mechanism of fraxetin against Staphylococcus aureus

Haiting Wang, Dan Zou, Kunpeing Xie, Mingjie Xie
Pages: 2341-2345
Published online on: 02 September 2014

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Article Open Access

Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin‑resistant ovarian cancer

Ya Xie, Zheng Peng, Mingxing Shi, Mei Ji, Hongjun Guo, Huirong Shi
Pages: 2346-2350
Published online on: 14 August 2014

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Article Open Access

Liraglutide reduces lipid accumulation in steatotic L‑02 cells by enhancing autophagy

Shi‑Wei Zhou, Man Zhang, Min Zhu
Pages: 2351-2357
Published online on: 15 September 2014

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Article Open Access

Desmocollin‑2 affects the adhesive strength and cytoskeletal arrangement in esophageal squamous cell carcinoma cells

Wang‑Kai Fang, Lian‑Di Liao, Fa‑Min Zeng, Pi‑Xian Zhang, Jian‑Yi Wu, Jian Shen, Li‑Yan Xu, En‑Min Li
Pages: 2358-2364
Published online on: 12 August 2014

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Article Open Access

Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism

Gang Zhang, Maidong Li, Shuwen Han, Dongyun Chen, Ying Wang, Wencai Ye, Zhaoning Ji
Pages: 2365-2371
Published online on: 03 September 2014

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Article

Effects of combining low‑dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome

Yue Zhao, Botao Du, Xiaoying Jiang, Mingxing Ma, Liqing Shi, Qinxi Zhang, Lili Zhou
Pages: 2372-2376
Published online on: 16 September 2014

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Article

Toll-like receptor (TLR) expression and TLR‑mediated interleukin-8 production by human submandibular gland epithelial cells

Kouji Ohta, Yoko Ishida, Akiko Fukui, Kuniko Mizuta, Hiromi Nishi, Masaaki Takechi, Nobuyuki Kamata
Pages: 2377-2382
Published online on: 21 August 2014

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Article

Clinical characteristics and pathogenesis of cerebellar glioblastoma

Yoshinobu Takahashi, Keishi Makino, Hideo Nakamura, Takuichiro  Hide, Shigetoshi Yano, Hajime Kamada, Jun-Ichi Kuratsu
Pages: 2383-2388
Published online on: 09 September 2014

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Article

Involvement of IL‑10 and granulocyte colony‑stimulating factor in the fate of monocytes controlled by galectin‑1

Da‑En Cheng, Wei‑An Chang, Jen‑Yu Hung, Ming‑Shyan Huang, Po‑Lin Kuo
Pages: 2389-2394
Published online on: 16 September 2014

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Article

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease

Chen-Geng Liu, Jing Song, Yue-Qi Zhang, Pei-Chang Wang
Pages: 2395-2400
Published online on: 12 August 2014

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Article

MicroRNA-185 suppresses growth and invasion of colon cancer cells through inhibition of the hypoxia‑inducible factor-2α pathway in vitro and in vivo

Zhan-Jun Lu, Lun-Gen Lu, Kai-Zhong Tao, Da-Fan Chen, Qing Xia, Jian‑Jun Weng, Feng Zhu, Xing-Peng Wang, Ping Zheng
Pages: 2401-2408
Published online on: 12 September 2014

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Article

PDGF regulates chondrocyte proliferation through activation of the GIT1- and PLCγ1-mediated ERK1/2 signaling pathway

Jin Xiao, Xuqiong Chen, Lipeng Xu, Ying Zhang, Qingshui Yin, Fei Wang
Pages: 2409-2414
Published online on: 21 August 2014

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Article

Screening of diagnostic markers for osteosarcoma

Dajiang Wu, Kai Chen, Yushu Bai, Xiaodong Zhu, Ziqiang Chen, Chuanfeng Wang, Yingchuan Zhao, Ming Li
Pages: 2415-2420
Published online on: 08 September 2014

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Article

Differential co-expression analysis of rheumatoid arthritis with microarray data

Kunpeng Wang, Liqiang Zhao, Xuefeng Liu, Zhenyong Hao, Yong Zhou, Chuandong Yang, Hongqiang Li
Pages: 2421-2426
Published online on: 14 August 2014

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Article

Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study

Renhong He, Jianzhong Fan
Pages: 2427-2432
Published online on: 21 August 2014

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Article

Estrogen stimulates the invasion of ovarian cancer cells via activation of the PI3K/AKT pathway and regulation of its downstream targets E‑cadherin and α‑actinin‑4

Zhiying Lu, Ying Zhang, Xiaohui Yan, Yisong Chen, Xiang Tao, Jiajia Wang, Nan Jia, Tianjiao Lyu, Junyan Wang, Jingxin Ding, Weiwei Feng, Keqin Hua
Pages: 2433-2440
Published online on: 12 September 2014

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Article

Learning curve for endobronchial ultrasound‑guided transbronchial needle aspiration: Experience of a community‑based teaching hospital

He Wang, Cyril D'Cruz, David C. Yam, Lorie M. Dilla, Patricia Tsang
Pages: 2441-2446
Published online on: 03 September 2014

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Article

Exenatide enhances INS-1 rat pancreatic β‑cell mass by increasing the protein levels of adiponectin and reducing the levels of C-reactive protein

Huibiao Quan, Yongyi Gao, Huachuan Zhang, Tuanyu Fang, Daoxiong Chen, Zhaohui Lv, Yanming Chen
Pages: 2447-2452
Published online on: 05 September 2014

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Article

Function of ghrelin and ghrelin receptors in the network regulation of gastric motility

Cheng-Guang Yang, Zuo-Fu Liao, Wen-Cai Qiu, Jun Yan, Zhi-Gang Wang
Pages: 2453-2458
Published online on: 16 September 2014

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Article

Calcium/calmodulin‑dependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factor‑κB and Akt‑mediated matrix metalloproteinase‑9 production

Zhaolong Liu, Gang Han, Yu Cao, Yidong Wang, Hangjun Gong
Pages: 2459-2464
Published online on: 28 August 2014

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Article

Detection of chromosomal abnormalities and the 22q11 microdeletion in fetuses with congenital heart defects

Wei Lv, Shuyu Wang
Pages: 2465-2470
Published online on: 12 September 2014

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Article

Role of the TGFβ/p65 pathway in tanshinone ⅡA-treated HBZY‑1 cells

Gangyi Chen, Xingju Zhang, Chao Li, Yingying Lin, Yu Meng, Shuifu Tang
Pages: 2471-2476
Published online on: 18 August 2014

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Article

Antitumor effect of a copper (II) complex of a coumarin derivative and phenanthroline on lung adenocarcinoma cells and the mechanism of action

Taofeng Zhu, Ruhua Chen, Hao Yu, Yan Feng, Jianqiang  Chen, Qin Lu, Jing Xie, Weiliang Ding, Tieliang Ma
Pages: 2477-2482
Published online on: 26 August 2014

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Article

Novel mechanism of intra‑renal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats

Xiaoqin Fan, Kaishan Liu, Wei Cui, Jiongmei Huang, Weina Wang, Yuan Gao
Pages: 2483-2488
Published online on: 14 August 2014

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Article

FOS-like antigen 1 is highly expressed in human psoriasis tissues and promotes the growth of HaCaT cells in vitro

Wu Zhu, Jing Li, Juan Su, Jie Li, Jinmao Li, Bo Deng, Qian Shi, Yanhong Zhou, Xiang Chen
Pages: 2489-2494
Published online on: 21 August 2014

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Article

Stem cell characteristics of dormant cells and cisplatin‑induced effects on the stemness of epithelial ovarian cancer cells

Nan Zhou, Xiaohua Wu, Bo Yang, Xu Yang, Dingding Zhang, Guo Qing
Pages: 2495-2504
Published online on: 12 August 2014

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Article

Curcumin inhibits hypoxia inducible factor‑1α‑induced epithelial‑mesenchymal transition in HepG2 hepatocellular carcinoma cells

Wanxing Duan, Yuanhong Chang, Rong Li, Qinhong Xu, Jianjun Lei, Caiqiao Yin, Ting Li, Yanzhao Wu, Qingyong Ma, Xuqi Li
Pages: 2505-2510
Published online on: 09 September 2014

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Article

A proteomics study of hyperhomocysteinemia injury of the hippocampal neurons using iTRAQ

Min Fang, Jing Wang, Han Yan, Yan‑Xin Zhao, Xue‑Yuan Liu
Pages: 2511-2516
Published online on: 11 September 2014

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Article

Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart

Nan Wu, Wenna Li, Wenqi Shu, Yan Lv, Dalin Jia
Pages: 2517-2524
Published online on: 15 September 2014

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Article

Duhuo Jisheng Decoction‑containing serum promotes proliferation of interleukin‑1β‑induced chondrocytes through the p16‑cyclin D1/CDK4‑Rb pathway

Guangwen Wu, Huailing Fan, Yuanpeng Huang, Chunsong Zheng, Jinxia Ye, Xianxiang Liu
Pages: 2525-2534
Published online on: 02 September 2014

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Article

Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer

Jun Wang, Zi-Rong Yang, Xu-Feng Guo, Jia Song, Ji‑Xiang  Zhang, Jing Wang, Wei-Guo Dong
Pages: 2535-2541
Published online on: 05 September 2014

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Article

Resveratrol attenuates hypoxia/reoxygenation‑induced Ca2+ overload by inhibiting the Wnt5a/Frizzled‑2 pathway in rat H9c2 cells

Xiang Wu, Shanshan Zhou, Ning Zhu, Xianbao Wang, Wen Jin, Xudong Song, Aihua Chen
Pages: 2542-2548
Published online on: 14 August 2014

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Article

All-trans retinoic acid suppresses apoptosis in PC12 cells injured by oxygen and glucose deprivation via the retinoic acid receptor α signaling pathway

Xiaojian Zhang, Qin Yu, Wei Jiang, Yang Bi, Yun Zhang, Min Gong, Xiaoping Wei, Tingyu Li, Jie Chen
Pages: 2549-2555
Published online on: 15 September 2014

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Article

Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho‑signal transducer and activator of transcription 3/hypoxia‑inducible factor‑1α pathway in hepatocellular carcinoma cells

Shuixiang He, Guifang Lu, Helei Hou, Zhenjun Zhao, Zhanfang Zhu, Xinlan Lu, Jinghong Chen, Zhilun Wang
Pages: 2556-2562
Published online on: 16 September 2014

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Article

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

Yong Qin, Zhenhua Ma, Xiaoyan Dang, Wei Li, Qingyong Ma
Pages: 2563-2567
Published online on: 21 August 2014

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Article

Synergy of urokinase‑type plasminogen activator receptor isomer (D1D2) and integrin α5β1 causes malignant transformation of hepatic cells and the occurrence of liver cancer

Ying-Qun Zhou, Xiao-Ping Lv, Shan Li, Bing Bai, Ling-Ling Zhan
Pages: 2568-2574
Published online on: 20 August 2014

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Article

Low expression of microRNA-30c promotes invasion by inducing epithelial mesenchymal transition in non-small cell lung cancer

Zhaopeng Zhong, Yang Xia, Pengli Wang, Bin Liu, Yijiang Chen
Pages: 2575-2579
Published online on: 14 August 2014

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Article

Hepatitis B virus inhibits the expression of CD82 through hypermethylation of its promoter in hepatoma cells

Guozheng Yu, Yuntao Bing, Wei Li, Lin Xia, Zhisu Liu
Pages: 2580-2586
Published online on: 14 August 2014

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Article

Liraglutide ameliorates renal injury in streptozotocin‑induced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor‑κB pathway

Sai‑Jun Zhou, Lian Bai, Lin Lv, Rui Chen, Chun‑Jun Li, Xiang‑Yang Liu, De‑Min Yu, Pei Yu
Pages: 2587-2594
Published online on: 10 September 2014

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Article

TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion

Hou-Gen Lu, Wang Zhan, Lin Yan, Rui-Ying Qin, Yi-Peng Yan, Zhen-Jiang Yang, Gui‑Chao  Liu, Gui-Qin Li, Hai-Feng Wang, Xing-Liang Li, Zhi Li, Lu Gao, Guo-Qing Chen
Pages: 2595-2600
Published online on: 26 August 2014

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Article

Reduced miR-125a-5p expression is associated with gastric carcinogenesis through the targeting of E2F3

Yanjun Xu, Zhenxia Huang, Yueli Liu
Pages: 2601-2608
Published online on: 15 September 2014

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Article

Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells

Donghong Ju, Youming Xie
Pages: 2609-2612
Published online on: 28 August 2014

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Article

miR-193b directly targets STMN1 and uPA genes and suppresses tumor growth and metastasis in pancreatic cancer

Jian Li, Fujiao Kong, Kemin Wu, Kun Song, Jianfeng He, Weijia Sun
Pages: 2613-2620
Published online on: 11 September 2014

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Article

CADM1/TSLC1 inhibits melanoma cell line A375 invasion through the suppression of matrix metalloproteinases

Yan You, Jinfeng Zhang, Yulian Li, Yuzhen Li, Guangyue Shi, Langjuan Ma, Haiying Wei
Pages: 2621-2626
Published online on: 11 September 2014

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Article

Piperine effectively protects primary cultured atrial myocytes from oxidative damage in the infant rabbit model

Yongjiang Ma, Miao Tian, Pin Liu, Ziling Wang, Yuan Guan, Yan Liu, Yutang Wang, Zhaoliang Shan
Pages: 2627-2632
Published online on: 10 September 2014

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Genome-wide identification and expression analysis of microRNA involved in small cell lung cancer via deep sequencing

Chunhua Yan, Xiaodong Shi, Qiushi Wang, Yue Wang, Yaxin Liu, Xiaofei Zhang, Yuandi Yang, Fuzhen Lv, Yuxia Shao
Pages: 2633-2642
Published online on: 04 September 2014

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MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells

Yang Yang, Menghe Li, Su'e Chang, Lumin Wang, Tusheng Song, Ling  Gao, Lili Hu, Zongfang Li, Liying Liu, Jiayi Yao, Chen Huang
Pages: 2643-2648
Published online on: 28 August 2014

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Aberrant expression of p-STAT3 in peripheral blood CD4+ and CD8+ T cells related to hepatocellular carcinoma development

Xu Wang, Wenbin Xin, Hua Zhang, Fengmei Zhang, Meilan Gao, Lingling Yuan, Xiaoyan Xu, Xuemei Hu, Mingdong Zhao
Pages: 2649-2656
Published online on: 21 August 2014

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An enhanced immune response against G250, induced by a heterologous DNA prime‑protein boost vaccination, using polyethyleneimine as a DNA vaccine adjuvant

Zeqiang Sun, Bo Liu, Xiyun Ruan, Qingyong Liu
Pages: 2657-2662
Published online on: 04 September 2014

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Methanol extracts of Euphorbia cooperi inhibit the production of inflammatory mediators by inhibiting the activation of c‑Jun N‑terminal kinase and p38 in murine macrophages

Young‑Chang Cho, In‑Seon Lee, Huiyun Seo, Anna Ju, Deokkyu  Youn, Younghyun Kim, Jaehee Choun, Sayeon Cho
Pages: 2663-2668
Published online on: 11 September 2014

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Comparison of immunohistochemistry, four in situ hybridization methods and quantitative polymerase chain reaction for the molecular diagnosis of HER2 status in gastric cancer: A study of 55 cases

Libor Staněk, Tomáš Rozkoš, Jan Laco, Aleš Ryška, Luboš  Petruželka, Miroslav Důra, Pavel Dundr
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Published online on: 02 September 2014

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Phenethyl isothiocyanate suppresses cervical carcinoma metastasis potential and its molecular mechanism

Li Zhang, Quan Hao, Lewen Bao, Wenxin Liu, Xin Fu, Ying Chen, Huijuan Wu
Pages: 2675-2680
Published online on: 12 September 2014

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Preliminary detection of the anti‑tumour activity of indoline‑2,3‑dione derivative DH‑12a targeting aminopeptidase N

De‑Xuan Cui, Xue‑Jian Wang, Xiu‑Rong Zhang, Ting‑Kun Zhao, Xiu‑Xiang Guo, Shun‑Mei Liu, Bing Wang, Wen‑Quan Ma, Zhi‑Qin Gao
Pages: 2681-2688
Published online on: 09 September 2014

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Flavonoid content, free radical scavenging and increase in xanthine oxidase inhibitory activity in Galgeun-tang following fermentation with Lactobacillus plantarum

Dong-Seon Kim, Young Ran Um, Jin Yeul Ma
Pages: 2689-2693
Published online on: 13 August 2014

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Evaluation of respiratory impedance in patients with chronic obstructive pulmonary disease by an impulse oscillation system

Su‑Gang Gong, Wen‑Lan Yang, Wei Zheng, Jin‑Ming Liu
Pages: 2694-2700
Published online on: 02 September 2014

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Effect of adenovirus‑mediated uPA gene transduction on the fibrinolytic activity of human umbilical vein endothelial cells

Weimin Zhou
Pages: 2701-2705
Published online on: 26 August 2014

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MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males

Torbjörn K. Nilsson, Anna K. Böttiger, Patricia Henríquez, Lluís Serra Majem
Pages: 2706-2712
Published online on: 28 August 2014

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Effects of all‑trans retinoic acid on VEGF and HIF‑1α expression in glioma cells under normoxia and hypoxia and its anti‑angiogenic effect in an intracerebral glioma model

Chen Liang, Shiwen Guo, Ling Yang
Pages: 2713-2719
Published online on: 05 September 2014

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Knockdown of Y‑box‑binding protein‑1 inhibits the malignant progression of HT‑29 colorectal adenocarcinoma cells by reversing epithelial‑mesenchymal transition

Xue‑Bing Yan, Qing‑Chao Zhu, Hong‑Qi Chen, Jia‑Yuan Peng, Hong‑Lei  Chao, Hang‑Xiang Du, Zhi‑Gang Wang, Zhi‑Ming Jin
Pages: 2720-2728
Published online on: 05 September 2014

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Suberoylanilide hydroxamic acid enhances the antitumor activity of oxaliplatin by reversing the oxaliplatin‑induced Src activation in gastric cancer cells

Chenfei Zhou, Jun Ji, Min Shi, Liu Yang, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang
Pages: 2729-2735
Published online on: 09 September 2014

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Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population

Rui Wang, Jun Zhang, Yanyun Ma, Linqi Chen, Shicheng Guo, Xiaojiao Zhang, Yunfang Ma, Lijun Wu, Xiaoyu Pei, Siran Liu, Jiucun Wang, Heping Hu, Jie Liu
Pages: 2736-2744
Published online on: 04 September 2014

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Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells

Haiying Wang, Wenyuan Ding, Dalong Yang, Tixin Gu, Sidong Yang, Zhilong Bai
Pages: 2745-2751
Published online on: 22 August 2014

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Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells

Wei-Guo Zhang, Xiao-Fang Liu, Ke-Wei Meng, San-Yuan Hu
Pages: 2752-2758
Published online on: 21 August 2014

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Peroxisome proliferator‑activated receptor γ polymorphisms as risk factors for dyslipidemia

Shu‑Jun Gu, Zhi‑Rong Guo, Zheng‑Yuan Zhou, Xiao‑Shu Hu, Ming Wu, Ning Zhang
Pages: 2759-2763
Published online on: 10 September 2014

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Tanshinol protects human umbilical vein endothelial cells against hydrogen peroxide‑induced apoptosis

Wei Song, Jun Pu, Ben He
Pages: 2764-2770
Published online on: 05 September 2014

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July-2026 Volume 34 Issue 1

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Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Regulatory mechanisms and therapeutic potential of N6-methyladenosine modification in retinal diseases (Review)

Wenyao Zhang, Jinying Chen, Jingxiang Zhong
Article Number: 213
Published online on: 29 May 2026

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Epigenetic orchestration of scar formation: Therapeutic potential of targeting DNA methylation and non‑coding RNAs in cutaneous fibrosis (Review)

Jinshun Li, Weiyun Liu, Jin Yang, Yanan Li
Article Number: 212
Published online on: 29 May 2026

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Elucidating the multitarget neuroprotective mechanisms of protocatechuic acid in neurological disorders (Review)

Xiaoyan Xue, Yongchang Lai, Shasha Song, Liping Wu, Lifang Wang
Article Number: 211
Published online on: 29 May 2026

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[Retracted] Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells

Yuan Zeng, Ying Yang
Article Number: 210
Published online on: 27 May 2026

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FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression

Linyu Jin, Jing Zhang, Wenjing Wang, Nan Zhang, Yang Liu, Alin Tian, Weiwei Yin, Yongle Qiu
Article Number: 209
Published online on: 25 May 2026

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Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review)

Songhua Nan, Chaojie Peng, Xue Meng, Jingnan Jia, Fangfang Zhao, Yinglin Cui
Article Number: 208
Published online on: 22 May 2026

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Mechanisms of pruritus and advances in traditional Chinese medicine therapy (Review)

Hailing Zhang, Yongji Li, Yuan Liu, Danyi Feng, Letao Zhao, Ran Chen, Xiwu Zhang, Jinjin Dou
Article Number: 207
Published online on: 22 May 2026

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Reprogramming of the hepatic ubiquitin‑immune axis: A unifying mechanism in liver disease progression (Review)

Yadi Ju, Xiaodan Chong, Weichen Ning, Yan Shi, Yangyang Li, Yihai Shi
Article Number: 206
Published online on: 22 May 2026

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Role of the PI3K/AKT signaling pathway in regulating gene expression in rheumatoid arthritis (Review)

Chengzhi Cong, Yuan Wang, Jian Liu, Chao Jin
Article Number: 205
Published online on: 21 May 2026

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Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)

Fatima Zohra Attouahri, Imane Chaoui, Abdelilah Laraqui, Mohamed Rida Tagajdid, Mohammed Oukabli, Mohammed El Marjany, Meriem Khyatti, Mohammed Attaleb, Mouna Ababou, Khalid Ennibi, Khaoula Errafii, Mohammed El Mzibri
Article Number: 204
Published online on: 21 May 2026

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Epigenetic research methods and animal models for intervertebral disc degeneration (Review)

Xinliang Cui, Li Zeng, Wei Zhang, Leimin Xi, Rui Wang, Diff Jia, Safa, Haoyu Feng, Huidong Jia
Article Number: 203
Published online on: 21 May 2026

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ZBTB16 upregulation maintains copper homeostasis to support esophageal tumor progression

Jingyi Wang, Bin Yang, Shengzu Peng, Bin Yang
Article Number: 202
Published online on: 21 May 2026

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[Corrigendum] MicroRNA‑1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post‑​transcriptional suppression of Ihh expression  

Taoyu Chen, Xianda Che, Pengfei Han, Jiangong Lu, Chunfang Wang, Bin Liang, Ziqi Hou, Xiaochun Wei, Lei Wei, Pengcui Li
Article Number: 201
Published online on: 20 May 2026

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Estrogen deficiency as a common driver and integrative mechanism in osteoporosis‑osteoarthritis comorbidity (Review)

Jian Cheng, Xiaodong Wu, Lu Zhao, Shuai Jiang, Wenjie Zhao, Weishuai Zhang
Article Number: 200
Published online on: 20 May 2026

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Role of RNA 5‑methylcytosine modification in cancer: Insights from coding and non‑coding RNAs (Review)

Qin Jiang, Yi Gong, Mimi Zhai, Tenglong Tang, Sushun Liu
Article Number: 199
Published online on: 20 May 2026

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m6A modification in skeletal system diseases (Review)

Xi Xie, Chen Li, Haotian Zheng, Guang Gan, Xi Gao
Article Number: 198
Published online on: 19 May 2026

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Dynamic regulation of the ‘mitochondria‑immune axis’ in myocardial infarction: Molecular mechanisms driving macrophage polarization through energy metabolism disorders (Review)

Yu Zhang, Hao Feng, Qin Wu, Shuxian Yang, Yundong Jiang, Houping Xu, Li Dong, Xiaolin Li, Hui Chen, Gang Luo
Article Number: 197
Published online on: 19 May 2026

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[Retracted] Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen‑activated protein kinase signaling pathway

Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wang
Article Number: 196
Published online on: 18 May 2026

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Polysaccharides: Natural candidates for targeting immunometabolic regulation in hepatocellular carcinoma (Review)

Changmei Wu, Jinjin Dou, Xiwu Zhang
Article Number: 195
Published online on: 18 May 2026

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NF‑κB signaling drives Th17‑mediated lacrimal gland injury and tear dysfunction in a murine model of primary Sjögren's syndrome

Jiajun Xie, Huina Zhang, Wenyue Shen, Juan Ye
Article Number: 194
Published online on: 18 May 2026

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POSTN(+) fibroblasts and SPP1(+) macrophages in scar formation: A review of mechanisms and therapeutic targets (Review)

Haotian Wu, Xianglin Dong
Article Number: 193
Published online on: 15 May 2026

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Emerging role of DYRK1A as a target in cardiovascular diseases (Review)

Liqing Yu, Qionghong Cheng, Jun Wu
Article Number: 192
Published online on: 15 May 2026

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[Retracted] Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

Peng Zou, Xiaoxiao Liu, Gang Li, Yangang Wang
Article Number: 191
Published online on: 05 May 2026

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Gut microbiota and its metabolites: Key factors of drug resistance in the treatment of advanced prostate cancer (Review)

Jingheng Song, Hongguo Cui, Peisen Yang, Yankai Xu, Yuanyuan Liu, Gang Zhang, Yangyang Liu, Aimin Tian, Jizhong Che, Hui Sun, Zhengchao Zhang
Article Number: 190
Published online on: 04 May 2026

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Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells

Juan Li, Siqin Zhou, Yu Wang, Guanghan Ou, Danli Yang, Liwen Shen
Article Number: 189
Published online on: 04 May 2026

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Applications of humanized mice in Mycobacterium tuberculosis infections (Review)

Binghua Han, Fang Liu, Jinzhao Long, Jiongjiong Wang, Yange Cui, Haiyan Yang
Article Number: 188
Published online on: 04 May 2026

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Research progress on neutrophil extracellular traps in sepsis‑induced coagulopathy (Review)

Jiandong Hu, Mengli Jin, Zhihua Cao, Binbin Zheng, Yuan Zheng, Hao Shen
Article Number: 187
Published online on: 04 May 2026

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Multifaceted regulatory role of proline‑ and glutamine-rich splicing factor in tumors (Review)

Shilin Zhang, Zhenhua Li, Li Fu
Article Number: 186
Published online on: 04 May 2026

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Effects of ALDH2 gene expression on the oxidative stress‑mediated NF‑κB/mTOR pathway in ketamine‑induced cystitis

Xiao Jian Xi, Yong Yao, Peng Gu, Min Hao Zhang
Article Number: 185
Published online on: 04 May 2026

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[Retracted] Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury

Junchao Yao, Kebin Zheng, Xiang Zhang
Article Number: 184
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 34 Issue 2

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Impact Factor: 3.5

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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Retraction Open Access

[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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