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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2014 Volume 10 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Inflammatory response in Parkinson's disease (Review)

Junqiang Yan, Qizhi Fu, Liniu Cheng, Mingming Zhai, Wenjuan Wu, Lina Huang, Ganqin Du
Pages: 2223-2233
Published online on: 12 September 2014

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Review

ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)

Shahzad Khan, Chang Hua Wang
Pages: 2234-2240
Published online on: 03 September 2014

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Review

Research progress on the central mechanism underlying regulation of visceral biological rhythm by per2 (Review)

Liting Zhu, Jun Yu, Wenyi Zhang, Bin Xie, Yi Zhu
Pages: 2241-2248
Published online on: 11 September 2014

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Article Open Access

Effects of lentiviral infection of mesenchymal stem cells on the expression of octamer transcription factor 4

Jing Chang, Li Tang, Han Lei, Xiao-Gang Zhang, Zhong Zuo, Wei Huang, Hang Fu
Pages: 2249-2254
Published online on: 21 August 2014

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Article Open Access

Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model

Zeyu Zhang, Dan Liu, Bo Yi, Zhangping Liao, Lei Tang, Dong Yin, Ming He
Pages: 2255-2262
Published online on: 05 September 2014

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Article Open Access

Alterations in the expression of vascular endothelial growth factor in the rat brain following gamma knife surgery

Lei Cheng, Lin Ma, Hecheng Ren, Hongwei Zhao, Yiqiang  Pang, Yongheng Wang, Ming Wei
Pages: 2263-2270
Published online on: 27 August 2014

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Article Open Access

1‑calcium phosphate‑uracil, a synthesized pyrimidine derivative agent, has anti‑proliferative, pro‑apoptotic and anti‑invasion effects on multiple tumor cell lines

Jing Peng, Xinlian Chen, Qian Hu, Mei Yang, Hongqian  Liu, Wei Wei, Shanling Liu, He Wang
Pages: 2271-2278
Published online on: 14 August 2014

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Article Open Access

Death receptor 5 expression IS inversely correlated WITH prostate cancer progression Corrigendum in /10.3892/mco.2017.7234

Angeles Hernandez‑Cueto, Daniel Hernandez‑Cueto, Gabriela Antonio‑Andres, Marisela Mendoza‑Marin, Carlos Jimenez‑Gutierrez, Ana Lilia Sandoval‑Mejia, Rosario Mora‑Campos, Cesar Gonzalez‑Bonilla, Mario I. Vega, Benjamin Bonavida, Sara Huerta‑Yepez
Pages: 2279-2286
Published online on: 21 August 2014

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Article Open Access

Milk thistle seed extract protects rat C6 astroglial cells from acute cocaine toxicity

Ramesh B. Badisa, Cheryl A. Fitch-Pye, Maryam Agharahimi, Donald E. Palm, Lekan M. Latinwo, Carl B. Goodman
Pages: 2287-2292
Published online on: 28 August 2014

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Article Open Access

Secreted frizzled‑related protein 2 is epigenetically silenced and functions as a tumor suppressor in oral squamous cell carcinoma

Can Xiao, Lili Wang, Lifang Zhu, Chenping Zhang, Jianhua Zhou
Pages: 2293-2298
Published online on: 05 September 2014

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Article Open Access

Effect of bone marrow stromal cell transplantation on neurologic function and expression of VEGF in rats with focal cerebral ischemia

Nan Li, Ping Wang, Xue-Ling Ma, Juan Wang, Li-Jing Zhao, Li Du, Li-Ya Wang, Xin-Rui Wang, Kang-Ding Liu
Pages: 2299-2305
Published online on: 20 August 2014

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Article Open Access

Critical role of insulin‑like growth factor binding protein‑5 in methamphetamine‑induced apoptosis in cardiomyocytes

Ka‑Pui Leung, Yi‑Hong Qu, Dong‑Fang Qiao, Wei‑Bing Xie, Dong‑Ri Li, Jing‑Tao Xu, Hui‑Jun Wang, Xia  Yue
Pages: 2306-2312
Published online on: 16 September 2014

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Article Open Access

Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression

Shulian Li, Wanli Ma, Teng Fei, Qiang Lou, Yaqin Zhang, Xiukun  Cui, Xiaoming Qin, Jun  Zhang, Guangchao Liu, Zheng Dong, Yuanfang Ma, Zhengshun Song, Yanzhong Hu
Pages: 2313-2321
Published online on: 08 September 2014

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Article Open Access

Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome

Tarek Mazzawi, Doris Gundersen, Trygve Hausken, Magdy El‑Salhy
Pages: 2322-2336
Published online on: 18 August 2014

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Article

Suppression of scinderin modulates epithelial‑mesenchymal transition markers in highly metastatic gastric cancer cell line SGC‑7901

Xiao‑Min Chen, Jun‑Ming Guo, Ping Chen, Lian‑Gang Mao, Wei‑Yun Feng, Dong‑Hai Le, Ke‑Qiang Li
Pages: 2327-2333
Published online on: 28 August 2014

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Article Open Access

Opposite effects of cefoperazone and ceftazidime on S‑ribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate

Hui-Qing Shi, Feng-Jun Sun, Jian-Hong Chen, Xiao-Lan Yong, Qian-Yi Ou, Wei Feng, Pei-Yuan Xia
Pages: 2334-2340
Published online on: 05 September 2014

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Article Open Access

Antibacterial mechanism of fraxetin against Staphylococcus aureus

Haiting Wang, Dan Zou, Kunpeing Xie, Mingjie Xie
Pages: 2341-2345
Published online on: 02 September 2014

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Article Open Access

Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin‑resistant ovarian cancer

Ya Xie, Zheng Peng, Mingxing Shi, Mei Ji, Hongjun Guo, Huirong Shi
Pages: 2346-2350
Published online on: 14 August 2014

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Article Open Access

Liraglutide reduces lipid accumulation in steatotic L‑02 cells by enhancing autophagy

Shi‑Wei Zhou, Man Zhang, Min Zhu
Pages: 2351-2357
Published online on: 15 September 2014

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Article Open Access

Desmocollin‑2 affects the adhesive strength and cytoskeletal arrangement in esophageal squamous cell carcinoma cells

Wang‑Kai Fang, Lian‑Di Liao, Fa‑Min Zeng, Pi‑Xian Zhang, Jian‑Yi Wu, Jian Shen, Li‑Yan Xu, En‑Min Li
Pages: 2358-2364
Published online on: 12 August 2014

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Article Open Access

Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism

Gang Zhang, Maidong Li, Shuwen Han, Dongyun Chen, Ying Wang, Wencai Ye, Zhaoning Ji
Pages: 2365-2371
Published online on: 03 September 2014

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Article

Effects of combining low‑dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome

Yue Zhao, Botao Du, Xiaoying Jiang, Mingxing Ma, Liqing Shi, Qinxi Zhang, Lili Zhou
Pages: 2372-2376
Published online on: 16 September 2014

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Article

Toll-like receptor (TLR) expression and TLR‑mediated interleukin-8 production by human submandibular gland epithelial cells

Kouji Ohta, Yoko Ishida, Akiko Fukui, Kuniko Mizuta, Hiromi Nishi, Masaaki Takechi, Nobuyuki Kamata
Pages: 2377-2382
Published online on: 21 August 2014

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Article

Clinical characteristics and pathogenesis of cerebellar glioblastoma

Yoshinobu Takahashi, Keishi Makino, Hideo Nakamura, Takuichiro  Hide, Shigetoshi Yano, Hajime Kamada, Jun-Ichi Kuratsu
Pages: 2383-2388
Published online on: 09 September 2014

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Article

Involvement of IL‑10 and granulocyte colony‑stimulating factor in the fate of monocytes controlled by galectin‑1

Da‑En Cheng, Wei‑An Chang, Jen‑Yu Hung, Ming‑Shyan Huang, Po‑Lin Kuo
Pages: 2389-2394
Published online on: 16 September 2014

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Article

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease

Chen-Geng Liu, Jing Song, Yue-Qi Zhang, Pei-Chang Wang
Pages: 2395-2400
Published online on: 12 August 2014

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Article

MicroRNA-185 suppresses growth and invasion of colon cancer cells through inhibition of the hypoxia‑inducible factor-2α pathway in vitro and in vivo

Zhan-Jun Lu, Lun-Gen Lu, Kai-Zhong Tao, Da-Fan Chen, Qing Xia, Jian‑Jun Weng, Feng Zhu, Xing-Peng Wang, Ping Zheng
Pages: 2401-2408
Published online on: 12 September 2014

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Article

PDGF regulates chondrocyte proliferation through activation of the GIT1- and PLCγ1-mediated ERK1/2 signaling pathway

Jin Xiao, Xuqiong Chen, Lipeng Xu, Ying Zhang, Qingshui Yin, Fei Wang
Pages: 2409-2414
Published online on: 21 August 2014

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Article

Screening of diagnostic markers for osteosarcoma

Dajiang Wu, Kai Chen, Yushu Bai, Xiaodong Zhu, Ziqiang Chen, Chuanfeng Wang, Yingchuan Zhao, Ming Li
Pages: 2415-2420
Published online on: 08 September 2014

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Article

Differential co-expression analysis of rheumatoid arthritis with microarray data

Kunpeng Wang, Liqiang Zhao, Xuefeng Liu, Zhenyong Hao, Yong Zhou, Chuandong Yang, Hongqiang Li
Pages: 2421-2426
Published online on: 14 August 2014

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Article

Effects of infrasound on the growth of bone marrow mesenchymal stem cells: A pilot study

Renhong He, Jianzhong Fan
Pages: 2427-2432
Published online on: 21 August 2014

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Article

Estrogen stimulates the invasion of ovarian cancer cells via activation of the PI3K/AKT pathway and regulation of its downstream targets E‑cadherin and α‑actinin‑4

Zhiying Lu, Ying Zhang, Xiaohui Yan, Yisong Chen, Xiang Tao, Jiajia Wang, Nan Jia, Tianjiao Lyu, Junyan Wang, Jingxin Ding, Weiwei Feng, Keqin Hua
Pages: 2433-2440
Published online on: 12 September 2014

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Article

Learning curve for endobronchial ultrasound‑guided transbronchial needle aspiration: Experience of a community‑based teaching hospital

He Wang, Cyril D'Cruz, David C. Yam, Lorie M. Dilla, Patricia Tsang
Pages: 2441-2446
Published online on: 03 September 2014

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Article

Exenatide enhances INS-1 rat pancreatic β‑cell mass by increasing the protein levels of adiponectin and reducing the levels of C-reactive protein

Huibiao Quan, Yongyi Gao, Huachuan Zhang, Tuanyu Fang, Daoxiong Chen, Zhaohui Lv, Yanming Chen
Pages: 2447-2452
Published online on: 05 September 2014

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Article

Function of ghrelin and ghrelin receptors in the network regulation of gastric motility

Cheng-Guang Yang, Zuo-Fu Liao, Wen-Cai Qiu, Jun Yan, Zhi-Gang Wang
Pages: 2453-2458
Published online on: 16 September 2014

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Article

Calcium/calmodulin‑dependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factor‑κB and Akt‑mediated matrix metalloproteinase‑9 production

Zhaolong Liu, Gang Han, Yu Cao, Yidong Wang, Hangjun Gong
Pages: 2459-2464
Published online on: 28 August 2014

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Article

Detection of chromosomal abnormalities and the 22q11 microdeletion in fetuses with congenital heart defects

Wei Lv, Shuyu Wang
Pages: 2465-2470
Published online on: 12 September 2014

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Article

Role of the TGFβ/p65 pathway in tanshinone ⅡA-treated HBZY‑1 cells

Gangyi Chen, Xingju Zhang, Chao Li, Yingying Lin, Yu Meng, Shuifu Tang
Pages: 2471-2476
Published online on: 18 August 2014

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Article

Antitumor effect of a copper (II) complex of a coumarin derivative and phenanthroline on lung adenocarcinoma cells and the mechanism of action

Taofeng Zhu, Ruhua Chen, Hao Yu, Yan Feng, Jianqiang  Chen, Qin Lu, Jing Xie, Weiliang Ding, Tieliang Ma
Pages: 2477-2482
Published online on: 26 August 2014

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Article

Novel mechanism of intra‑renal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats

Xiaoqin Fan, Kaishan Liu, Wei Cui, Jiongmei Huang, Weina Wang, Yuan Gao
Pages: 2483-2488
Published online on: 14 August 2014

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Article

FOS-like antigen 1 is highly expressed in human psoriasis tissues and promotes the growth of HaCaT cells in vitro

Wu Zhu, Jing Li, Juan Su, Jie Li, Jinmao Li, Bo Deng, Qian Shi, Yanhong Zhou, Xiang Chen
Pages: 2489-2494
Published online on: 21 August 2014

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Article

Stem cell characteristics of dormant cells and cisplatin‑induced effects on the stemness of epithelial ovarian cancer cells

Nan Zhou, Xiaohua Wu, Bo Yang, Xu Yang, Dingding Zhang, Guo Qing
Pages: 2495-2504
Published online on: 12 August 2014

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Article

Curcumin inhibits hypoxia inducible factor‑1α‑induced epithelial‑mesenchymal transition in HepG2 hepatocellular carcinoma cells

Wanxing Duan, Yuanhong Chang, Rong Li, Qinhong Xu, Jianjun Lei, Caiqiao Yin, Ting Li, Yanzhao Wu, Qingyong Ma, Xuqi Li
Pages: 2505-2510
Published online on: 09 September 2014

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Article

A proteomics study of hyperhomocysteinemia injury of the hippocampal neurons using iTRAQ

Min Fang, Jing Wang, Han Yan, Yan‑Xin Zhao, Xue‑Yuan Liu
Pages: 2511-2516
Published online on: 11 September 2014

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Article

Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart

Nan Wu, Wenna Li, Wenqi Shu, Yan Lv, Dalin Jia
Pages: 2517-2524
Published online on: 15 September 2014

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Article

Duhuo Jisheng Decoction‑containing serum promotes proliferation of interleukin‑1β‑induced chondrocytes through the p16‑cyclin D1/CDK4‑Rb pathway

Guangwen Wu, Huailing Fan, Yuanpeng Huang, Chunsong Zheng, Jinxia Ye, Xianxiang Liu
Pages: 2525-2534
Published online on: 02 September 2014

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Article

Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer

Jun Wang, Zi-Rong Yang, Xu-Feng Guo, Jia Song, Ji‑Xiang  Zhang, Jing Wang, Wei-Guo Dong
Pages: 2535-2541
Published online on: 05 September 2014

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Article

Resveratrol attenuates hypoxia/reoxygenation‑induced Ca2+ overload by inhibiting the Wnt5a/Frizzled‑2 pathway in rat H9c2 cells

Xiang Wu, Shanshan Zhou, Ning Zhu, Xianbao Wang, Wen Jin, Xudong Song, Aihua Chen
Pages: 2542-2548
Published online on: 14 August 2014

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Article

All-trans retinoic acid suppresses apoptosis in PC12 cells injured by oxygen and glucose deprivation via the retinoic acid receptor α signaling pathway

Xiaojian Zhang, Qin Yu, Wei Jiang, Yang Bi, Yun Zhang, Min Gong, Xiaoping Wei, Tingyu Li, Jie Chen
Pages: 2549-2555
Published online on: 15 September 2014

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Article

Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho‑signal transducer and activator of transcription 3/hypoxia‑inducible factor‑1α pathway in hepatocellular carcinoma cells

Shuixiang He, Guifang Lu, Helei Hou, Zhenjun Zhao, Zhanfang Zhu, Xinlan Lu, Jinghong Chen, Zhilun Wang
Pages: 2556-2562
Published online on: 16 September 2014

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Article

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

Yong Qin, Zhenhua Ma, Xiaoyan Dang, Wei Li, Qingyong Ma
Pages: 2563-2567
Published online on: 21 August 2014

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Article

Synergy of urokinase‑type plasminogen activator receptor isomer (D1D2) and integrin α5β1 causes malignant transformation of hepatic cells and the occurrence of liver cancer

Ying-Qun Zhou, Xiao-Ping Lv, Shan Li, Bing Bai, Ling-Ling Zhan
Pages: 2568-2574
Published online on: 20 August 2014

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Article

Low expression of microRNA-30c promotes invasion by inducing epithelial mesenchymal transition in non-small cell lung cancer

Zhaopeng Zhong, Yang Xia, Pengli Wang, Bin Liu, Yijiang Chen
Pages: 2575-2579
Published online on: 14 August 2014

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Article

Hepatitis B virus inhibits the expression of CD82 through hypermethylation of its promoter in hepatoma cells

Guozheng Yu, Yuntao Bing, Wei Li, Lin Xia, Zhisu Liu
Pages: 2580-2586
Published online on: 14 August 2014

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Article

Liraglutide ameliorates renal injury in streptozotocin‑induced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor‑κB pathway

Sai‑Jun Zhou, Lian Bai, Lin Lv, Rui Chen, Chun‑Jun Li, Xiang‑Yang Liu, De‑Min Yu, Pei Yu
Pages: 2587-2594
Published online on: 10 September 2014

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Article

TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion

Hou-Gen Lu, Wang Zhan, Lin Yan, Rui-Ying Qin, Yi-Peng Yan, Zhen-Jiang Yang, Gui‑Chao  Liu, Gui-Qin Li, Hai-Feng Wang, Xing-Liang Li, Zhi Li, Lu Gao, Guo-Qing Chen
Pages: 2595-2600
Published online on: 26 August 2014

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Article

Reduced miR-125a-5p expression is associated with gastric carcinogenesis through the targeting of E2F3

Yanjun Xu, Zhenxia Huang, Yueli Liu
Pages: 2601-2608
Published online on: 15 September 2014

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Article

Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells

Donghong Ju, Youming Xie
Pages: 2609-2612
Published online on: 28 August 2014

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Article

miR-193b directly targets STMN1 and uPA genes and suppresses tumor growth and metastasis in pancreatic cancer

Jian Li, Fujiao Kong, Kemin Wu, Kun Song, Jianfeng He, Weijia Sun
Pages: 2613-2620
Published online on: 11 September 2014

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Article

CADM1/TSLC1 inhibits melanoma cell line A375 invasion through the suppression of matrix metalloproteinases

Yan You, Jinfeng Zhang, Yulian Li, Yuzhen Li, Guangyue Shi, Langjuan Ma, Haiying Wei
Pages: 2621-2626
Published online on: 11 September 2014

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Article

Piperine effectively protects primary cultured atrial myocytes from oxidative damage in the infant rabbit model

Yongjiang Ma, Miao Tian, Pin Liu, Ziling Wang, Yuan Guan, Yan Liu, Yutang Wang, Zhaoliang Shan
Pages: 2627-2632
Published online on: 10 September 2014

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Article

Genome-wide identification and expression analysis of microRNA involved in small cell lung cancer via deep sequencing

Chunhua Yan, Xiaodong Shi, Qiushi Wang, Yue Wang, Yaxin Liu, Xiaofei Zhang, Yuandi Yang, Fuzhen Lv, Yuxia Shao
Pages: 2633-2642
Published online on: 04 September 2014

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MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells

Yang Yang, Menghe Li, Su'e Chang, Lumin Wang, Tusheng Song, Ling  Gao, Lili Hu, Zongfang Li, Liying Liu, Jiayi Yao, Chen Huang
Pages: 2643-2648
Published online on: 28 August 2014

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Aberrant expression of p-STAT3 in peripheral blood CD4+ and CD8+ T cells related to hepatocellular carcinoma development

Xu Wang, Wenbin Xin, Hua Zhang, Fengmei Zhang, Meilan Gao, Lingling Yuan, Xiaoyan Xu, Xuemei Hu, Mingdong Zhao
Pages: 2649-2656
Published online on: 21 August 2014

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An enhanced immune response against G250, induced by a heterologous DNA prime‑protein boost vaccination, using polyethyleneimine as a DNA vaccine adjuvant

Zeqiang Sun, Bo Liu, Xiyun Ruan, Qingyong Liu
Pages: 2657-2662
Published online on: 04 September 2014

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Methanol extracts of Euphorbia cooperi inhibit the production of inflammatory mediators by inhibiting the activation of c‑Jun N‑terminal kinase and p38 in murine macrophages

Young‑Chang Cho, In‑Seon Lee, Huiyun Seo, Anna Ju, Deokkyu  Youn, Younghyun Kim, Jaehee Choun, Sayeon Cho
Pages: 2663-2668
Published online on: 11 September 2014

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Comparison of immunohistochemistry, four in situ hybridization methods and quantitative polymerase chain reaction for the molecular diagnosis of HER2 status in gastric cancer: A study of 55 cases

Libor Staněk, Tomáš Rozkoš, Jan Laco, Aleš Ryška, Luboš  Petruželka, Miroslav Důra, Pavel Dundr
Pages: 2669-2674
Published online on: 02 September 2014

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Phenethyl isothiocyanate suppresses cervical carcinoma metastasis potential and its molecular mechanism

Li Zhang, Quan Hao, Lewen Bao, Wenxin Liu, Xin Fu, Ying Chen, Huijuan Wu
Pages: 2675-2680
Published online on: 12 September 2014

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Preliminary detection of the anti‑tumour activity of indoline‑2,3‑dione derivative DH‑12a targeting aminopeptidase N

De‑Xuan Cui, Xue‑Jian Wang, Xiu‑Rong Zhang, Ting‑Kun Zhao, Xiu‑Xiang Guo, Shun‑Mei Liu, Bing Wang, Wen‑Quan Ma, Zhi‑Qin Gao
Pages: 2681-2688
Published online on: 09 September 2014

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Flavonoid content, free radical scavenging and increase in xanthine oxidase inhibitory activity in Galgeun-tang following fermentation with Lactobacillus plantarum

Dong-Seon Kim, Young Ran Um, Jin Yeul Ma
Pages: 2689-2693
Published online on: 13 August 2014

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Evaluation of respiratory impedance in patients with chronic obstructive pulmonary disease by an impulse oscillation system

Su‑Gang Gong, Wen‑Lan Yang, Wei Zheng, Jin‑Ming Liu
Pages: 2694-2700
Published online on: 02 September 2014

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Effect of adenovirus‑mediated uPA gene transduction on the fibrinolytic activity of human umbilical vein endothelial cells

Weimin Zhou
Pages: 2701-2705
Published online on: 26 August 2014

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MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males

Torbjörn K. Nilsson, Anna K. Böttiger, Patricia Henríquez, Lluís Serra Majem
Pages: 2706-2712
Published online on: 28 August 2014

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Effects of all‑trans retinoic acid on VEGF and HIF‑1α expression in glioma cells under normoxia and hypoxia and its anti‑angiogenic effect in an intracerebral glioma model

Chen Liang, Shiwen Guo, Ling Yang
Pages: 2713-2719
Published online on: 05 September 2014

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Knockdown of Y‑box‑binding protein‑1 inhibits the malignant progression of HT‑29 colorectal adenocarcinoma cells by reversing epithelial‑mesenchymal transition

Xue‑Bing Yan, Qing‑Chao Zhu, Hong‑Qi Chen, Jia‑Yuan Peng, Hong‑Lei  Chao, Hang‑Xiang Du, Zhi‑Gang Wang, Zhi‑Ming Jin
Pages: 2720-2728
Published online on: 05 September 2014

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Suberoylanilide hydroxamic acid enhances the antitumor activity of oxaliplatin by reversing the oxaliplatin‑induced Src activation in gastric cancer cells

Chenfei Zhou, Jun Ji, Min Shi, Liu Yang, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang
Pages: 2729-2735
Published online on: 09 September 2014

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Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population

Rui Wang, Jun Zhang, Yanyun Ma, Linqi Chen, Shicheng Guo, Xiaojiao Zhang, Yunfang Ma, Lijun Wu, Xiaoyu Pei, Siran Liu, Jiucun Wang, Heping Hu, Jie Liu
Pages: 2736-2744
Published online on: 04 September 2014

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Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells

Haiying Wang, Wenyuan Ding, Dalong Yang, Tixin Gu, Sidong Yang, Zhilong Bai
Pages: 2745-2751
Published online on: 22 August 2014

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Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells

Wei-Guo Zhang, Xiao-Fang Liu, Ke-Wei Meng, San-Yuan Hu
Pages: 2752-2758
Published online on: 21 August 2014

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Peroxisome proliferator‑activated receptor γ polymorphisms as risk factors for dyslipidemia

Shu‑Jun Gu, Zhi‑Rong Guo, Zheng‑Yuan Zhou, Xiao‑Shu Hu, Ming Wu, Ning Zhang
Pages: 2759-2763
Published online on: 10 September 2014

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Tanshinol protects human umbilical vein endothelial cells against hydrogen peroxide‑induced apoptosis

Wei Song, Jun Pu, Ben He
Pages: 2764-2770
Published online on: 05 September 2014

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October-2026 Volume 34 Issue 4

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression

Shuangxi Tu, Xiaodan Wang, Zhenbo Wang, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 296
Published online on: 03 September 2026

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Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review)

Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima
Article Number: 295
Published online on: 03 September 2026

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From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review)

Yuying Li, Ling Wei, Fang Sun, Huixia Wu, Xijun Sun, Yirong Gan, Xiaohua Kong
Article Number: 294
Published online on: 03 September 2026

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Resurrection biology: Melatonin as a modulator of anastasis (Review)

Alexandros Georgiou, Russel J. Reiter, Vassilis Zoumpourlis, Demetrios A. Spandidos
Article Number: 293
Published online on: 02 September 2026

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[Corrigendum] CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Qianle Yu, Kai Gao
Article Number: 292
Published online on: 01 September 2026

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Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review)

Xiufen Zhong, Jingtao Gui
Article Number: 291
Published online on: 28 August 2026

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POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy

Yongbo Ma, Xiaozhe Chen, Zixian Liu, Yulong Ma, Chunlei Hou, Yunfeng Li, Mingtai Gui, Bo Lu, Deyu Fu, Mingzhu Wang
Article Number: 290
Published online on: 26 August 2026

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[Corrigendum] Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Article Number: 289
Published online on: 24 August 2026

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Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review)

Laifeng Wu, Lingchen Liao, Ziwei Xia, Qiao Zeng, An Huang, Zhiyong Cao
Article Number: 288
Published online on: 21 August 2026

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Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review)

Xi Wang, Baojun Duan, Jun Bai, Huitong Liu
Article Number: 287
Published online on: 20 August 2026

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Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review)

Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li
Article Number: 286
Published online on: 20 August 2026

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Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis

Junjian Chen, Wanyi Zhang, Tao Hong, Junsheng Wang, Chuan Chen, Ying Zhang, Mi Hu, Ning You, Jietao Huang
Article Number: 285
Published online on: 20 August 2026

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[Corrigendum] Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons 

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu
Article Number: 284
Published online on: 20 August 2026

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Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review)

Qianqian Li, Yufang Ni, Zhaoyang Li, Jianchun Li, Li Wang
Article Number: 283
Published online on: 18 August 2026

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Biological mechanisms of atropine in myopia control (Review)

Qin Zhu, Guanglong Zhou, Lingguo Wang, Xuejiao Li, Zhijuan Hua, Jie Yin, Jieying Zhang, Yuan Zhou, Xiaofan Zhang, Allison Wilde, Yingting Zhu, Liping Xue
Article Number: 282
Published online on: 18 August 2026

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6'‑O‑Caffeoylarbutin attenuates experimental hyperuricemia by regulating renal and intestinal urate transport, intestinal barrier integrity, and gut microbiota

Xuezhi Yu, Yang Zhang, Konchun Sun, Rui Yang, Xingde Li, Xiuzhen Chen, Tiantian Li, Xiaolei Yang, Ming Li, Lu Liu, Fei Li, Baochun Shen
Article Number: 281
Published online on: 18 August 2026

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[Retracted] Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival  

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Article Number: 280
Published online on: 17 August 2026

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Uric acid enhances tumor stemness in breast cancer cells by upregulating GMPS

Zhiying Wang, Mingzhang Huang, Yuanqi Zhang, Siqi Huang, Wei Lei, Xiaorong Shui
Article Number: 279
Published online on: 13 August 2026

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Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis

Le-Yi Huang, Yao Chen, Lin-Ran Song, Zhuo-Lin Zhong, Kamran Ali, Hui-Min Li, Qing-Feng Hu, Hong-Hua Hu
Article Number: 278
Published online on: 13 August 2026

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Expression of Concern Open Access

[Expression of Concern] MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells

Shufang He, Guiyuan Yu, Ke Peng, Sisun Liu
Article Number: 277
Published online on: 12 August 2026

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Review

Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review)

Shaoying An, Wenhui Sun, Lizhou Shi, Hai Chen, Zhongcheng Mo
Article Number: 276
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis

Liang Hao, Yuying Wan, Juhua Xiao, Qiang Tang, Huan Deng, Lu Chen
Article Number: 275
Published online on: 10 August 2026

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Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu
Article Number: 274
Published online on: 06 August 2026

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Mitochondrial quality control in acute liver injury and its therapeutic implications (Review)

Ziqiang Chen, Yunhe Wang, Yijing Li, Gang Cong, Yunhang Chu, Yunhui Bai, Yishuo Zhang, Liya Zhou
Article Number: 273
Published online on: 05 August 2026

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STC1 promotes osteogenic differentiation and represses inflammation via inhibition of NF‑κB signaling in mesenchymal stromal cells

Chen Yang, Xin Li, Peng Wang, Yitong Chen, Erli Wu, Qian Chen, Jing Hu, Fu Zheng, Lamu Gongsang, Jiayu Li, Mengyuan Zhang, Jing Zhou, Bing Han, Amr A. Badreldin, Yuka Miyamoto, Jin Koo Kim, Insoon Chang, Jia Chang, Paul H. Krebsbach, Liyuan Huang, Xiaoping Xu, Xiaoyan Chen, Peng Deng, Qianming Chen, Lijie Fan
Article Number: 272
Published online on: 05 August 2026

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Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review)

Teng Sun, Lei Ye
Article Number: 271
Published online on: 04 August 2026

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Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review)

Fengyun Gao, Lili Wang, Guiyun Teng, Liqiong Shang
Article Number: 270
Published online on: 03 August 2026

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[Retracted] Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Article Number: 269
Published online on: 03 August 2026

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Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review)

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu
Article Number: 268
Published online on: 31 July 2026

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Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review)

Liqi Zhang, Shuxia Yang, Huiyan Wu, Hong Zhou
Article Number: 267
Published online on: 30 July 2026

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Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

Rongtou Huang, Danning Mo, Huitian Huang, Minmin Zhang, Wenhong Yu, Buqing Cao
Article Number: 266
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses

Yubo Xiao, Min Feng, Haiying Ran, Xiao Han, Xuegang Li
Article Number: 265
Published online on: 29 July 2026

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Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review)

Xiaona Wang, Hua Du, Yingxu Shi
Article Number: 264
Published online on: 28 July 2026

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Association between periodontitis and heart failure: Mechanisms and clinical implications (Review)

Xinyue Zhang, Xiaoli An
Article Number: 263
Published online on: 28 July 2026

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Article Open Access

Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene CLOCK

Jiawen Yu, Chunmei Qian, Renye Que, Yi Zhou
Article Number: 262
Published online on: 28 July 2026

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[Retracted] PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 261
Published online on: 27 July 2026

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UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analyses

Yun Wen, Pengfei Luo
Article Number: 260
Published online on: 23 July 2026

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Journal Cover
November-2026 Volume 34 Issue 5

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review)

Yuwen Zeng, Yutong Yan, Shiye Wu, Wanshan Wu, Ke Chen, Youyi Lai, Qing Ye, Nan Zhang, Yuanyuan Zhou
Article Number: 320
Published online on: 23 September 2026

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Lactylation in gastric cancer: From mechanisms to clinical applications (Review)

Yuliang Fang, Peng Chen, Yuhong Gao, Yanpiao Li, Xue Li
Article Number: 319
Published online on: 23 September 2026

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Article Open Access

Sleep deprivation exacerbates lens‑induced myopia in association with ERK/NF‑κB pathway activation

Xueli Yang, Zhou Zhang, Chengbai Zhu, Jianbo Li, Wenting Gong, Ruirui Yang, Lipeng Guan
Article Number: 318
Published online on: 22 September 2026

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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Article Open Access

High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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Retraction Open Access

[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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Article Open Access

A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Article Open Access

Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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Retraction Open Access

[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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Article Open Access

KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Review Open Access

Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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