Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2014 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2014 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males

  • Authors:
    • Torbjörn K. Nilsson
    • Anna K. Böttiger
    • Patricia Henríquez
    • Lluís Serra Majem
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå SE‑90185, Sweden, Department of Laboratory Medicine, Clinical Chemistry, Örebro University Hospital, Örebro SE‑70185, Sweden, Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas of Gran Canaria, Las Palmas 35016, Canary Islands, Spain
  • Pages: 2706-2712
    |
    Published online on: August 28, 2014
       https://doi.org/10.3892/mmr.2014.2521
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A total of 523 subjects (297 females and 226 males) from the Canary Islands Nutrition Study (ENCA) were studied in order to examine the effect of the MTHFR 677C>T, 1298A>C and 1793G>A polymorphisms, adjusted for age, serum (S)‑folate and S‑cobalamin levels, on total plasma homocysteine concentrations (tHcy). Genotyping was performed with Pyrosequencing® technology. The MTHFR 677T‑allele was associated with increased tHcy concentrations only in males (P=0.005). The MTHFR 1298C‑allele was found to be associated with higher tHcy levels but similarly, only in males (P=0.025). The MTHFR 1793A‑allele was associated with decreased tHcy concentrations in the younger males (P=0.042). A haplotype‑based approach was marginally superior in explaining the genetic interaction of the MTHFR polymorphisms on tHcy plasma levels (R2 0.352 vs. 0.342 for a simple genotype‑based approach). A nutrigenetic interaction between the MTHFR 677C>T genotype and S‑cobalamin on tHcy levels was demonstrated in both genders. The increase in tHcy was more pronounced with decreasing S‑cobalamin quintiles in 677TT homozygotes (P=0.005 for males and P=0.015 for females) than with decreasing S‑folate quintiles (P for trend not significant). It was concluded that gene‑nutrient interactions may differ depending on the sex and age of the subjects. The transferability of gene‑nutrient interactions from one community to others may therefore be limited not only by different food patterns but also by different ages, genders and genotype distributions.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Yamada K, Chen Z, Rozen R and Matthews RG: Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci USA. 98:14853–14858. 2001. View Article : Google Scholar

2 

Bolander-Gouaille C and Bottiglieri T: Homocysteine Related Vitamins and Neuropsychiatric Disorders. Springer; Paris: 2003

3 

Garcia A and Zanibbi K: Homocysteine and cognitive function in elderly people. CMAJ. 171:897–904. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Blom HJ: Determinants of plasma homocysteine. Am J Clin Nutr. 67:188–189. 1998.

5 

Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, et al: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 10:111–113. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Lievers KJ, Boers GH, Verhoef P, den Heijer M, Kluijtmans LA, van der Put NM, Trijbels FJ and Blom HJ: A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk. J Mol Med (Berl). 79:522–528. 2001. View Article : Google Scholar

7 

Mudd SH, Uhlendorf BW, Freeman JM, Finkelstein JD and Shih VE: Homocystinuria associated with decreased methylenetetrahydrofolate reductase activity. Biochem Biophys Res Commun. 46:905–912. 1972. View Article : Google Scholar : PubMed/NCBI

8 

Selhub J: Homocysteine metabolism. Annu Rev Nutr. 19:217–246. 1999. View Article : Google Scholar

9 

van der Put NM, Gabreëls F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP and Blom HJ: A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 62:1044–1051. 1998.PubMed/NCBI

10 

Weisberg I, Tran P, Christensen B, Sibani S and Rozen R: A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 64:169–172. 1998. View Article : Google Scholar

11 

Viel A, Dall’Agnese L, Simone F, Canzonieri V, Capozzi E, Visentin MC, Valle R and Boiocchi M: Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas. Br J Cancer. 75:1105–1110. 1997. View Article : Google Scholar : PubMed/NCBI

12 

de Bree A, Verschuren WM, Bjørke-Monsen AL, van der Put NM, Heil SG, Trijbels FJ and Blom HJ: Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr. 77:687–693. 2003.

13 

Cortese C and Motti C: MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr. 4:493–497. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Huemer M, Vonblon K, Födinger M, Krumpholz R, Hubmann M, Ulmer H and Simma B: Total homocysteine, folate, and cobalamin, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents. Pediatr Res. 60:764–769. 2006. View Article : Google Scholar

15 

Rady PL, Szucs S, Grady J, Hudnall SD, Kellner LH, Nitowsky H, Tyring SK and Matalon RK: Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A. Am J Med Genet. 107:162–168. 2002. View Article : Google Scholar

16 

Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Isoe-Wada K, Yano H, Urakami K, Takeshima T and Nakashima K: A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer’s disease. Neurobiol Aging. 25:291–294. 2004.PubMed/NCBI

17 

Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG and Ludwig ML: The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol. 6:359–365. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Isotalo PA, Wells GA and Donnelly JG: Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Am J Hum Genet. 67:986–990. 2000. View Article : Google Scholar

19 

Weisberg IS, Jacques PF, Selhub J, Bostom AG, Chen Z, Curtis Ellison R, Eckfeldt JH and Rozen R: The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis. 156:409–415. 2001.

20 

Böttiger AK, Hurtig-Wennlöf A, Sjöström M, Yngve A and Nilsson TK: Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T, 1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents. Int J Mol Med. 19:659–665. 2007.

21 

Henríquez P, Doreste J, Deulofeu R, Fiuza MD and Serra-Majem L: Nutritional determinants of plasma total homocysteine distribution in the Canary Islands. Eur J Clin Nutr. 61:111–118. 2007.PubMed/NCBI

22 

Serra Majem L, Ribas Barba L, Armas Navarro A, Alvarez León E and Sierra A: Equipo de investigación de ENCA: Energy and nutrient intake and risk of inadequate intakes in Canary Islands (1997–98). Arch Latinoam Nutr. 50(Suppl 1): 7–22. 2000.(In Spanish).

23 

Börjel AK, Yngve A, Sjöström M and Nilsson TK: Novel mutations in the 5′-UTR of the FOLR1 gene. Clin Chem Lab Med. 44:161–167. 2006.

24 

Zittan E, Preis M, Asmir I, Cassel A, Lindenfeld N, Alroy S, Halon DA, Lewis BS, Shiran A, Schliamser JE and Flugelman MY: High frequency of vitamin B12 deficiency in asymptomatic individuals homozygous to MTHFR C677T mutation is associated with endothelial dysfunction and homocysteinemia. Am J Physiol Heart Circ Physiol. 293:H860–H865. 2007. View Article : Google Scholar

25 

Martínez-Frías ML, Bermejo E, Rodríguez-Pinilla E, Scala I, Andria G and Botto L: Frequency of the mutation 677C-T of methylenetetrahydrofolate reductase gene on a sample of 652 Spanish liveborn infants. Med Clin (Barc). 122:361–364. 2004.(In Spanish).

26 

Martín I, Obrador A, Gibert MJ, Hernanz A, Fuster A, Pintos C, Garcia A and Tur J: Folate status and a new repletion cut-off value in a group of healthy Majorcan females. Clin Nutr. 22:53–58. 2003.PubMed/NCBI

27 

Brattström L, Zhang Y, Hurtig M, Refsum H, Ostensson S, Fransson L, Jonés K, Landgren F, Brudin L and Ueland PM: A common methylenetetrahydrofolate reductase gene mutation and longevity. Atherosclerosis. 141:315–319. 1998.PubMed/NCBI

28 

Brown KS, Kluijtmans LA, Young IS, Murray L, McMaster D, Woodside JV, Yarnell JW, Boreham CA, McNulty H, Strain JJ, et al: The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine. Atherosclerosis. 174:315–322. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Chango A, Potier De Courcy G, Boisson F, Guilland JC, Barbé F, Perrin MO, Christidès JP, Rabhi K, Pfister M, Galan P, et al: 5,10-methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplemalestation en Vitamines et Mineraux Antioxydants (SU.VIMAX) cohort. Br J Nutr. 84:891–896. 2000.

30 

Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, McNulty H, Strain JJ, McPartlin J, Scott JM and Whitehead AS: Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood. 101:2483–2488. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Dimitrova KR, DeGroot K, Myers AK and Kim YD: Estrogen and homocysteine. Cardiovasc Res. 53:577–588. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Fischer LM, da Costa KA, Galanko J, Sha W, Stephenson B, Vick J and Zeisel SH: Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. Am J Clin Nutr. 92:336–346. 2010. View Article : Google Scholar

33 

Stead LM, Brosnan JT, Brosnan ME, Vance DE and Jacobs RL: Is it time to reevaluate methyl balance in humans? Am J Clin Nutr. 83:5–10. 2006.PubMed/NCBI

34 

Yang QH, Botto LD, Gallagher M, Friedman JM, Sanders CL, Koontz D, Nikolova S, Erickson JD and Steinberg K: Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am J Clin Nutr. 88:232–246. 2008.

35 

Guéant-Rodriguez RM, Guéant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, Chabi NW, Sanni A, Anello G, et al: Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr. 83:701–707. 2006.PubMed/NCBI

36 

D’Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, Galli L and Cerbone AM: The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost. 83:563–570. 2000.

37 

Hustad S, Midttun Ø, Schneede J, Vollset SE, Grotmol T and Ueland PM: The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am J Hum Genet. 80:846–855. 2007.

38 

Sensoy N, Şoysal Y, Kahraman A, Doǧan N and Imirzalioǧlu N: Modulator effects of the methylenetetrahydrofolate reductase C677T polymorphism on response to vitamin B12 therapy and homocysteine metabolism. DNA Cell Biol. 31:820–825. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Arjona Mateos CR, Criado Velasco J and Sánches Solís L: Enfermedades crónicas y consumo de fármacos en mayores de 65 años. Medicina General. 47:684–695. 2002.(In Spanish).

40 

Gonzalez-Gross M, Sola R, Albers U, Barrios L, Alder M, Castillo MJ and Pietrzik K: B-vitamins and homocysteine in Spanish institutionalized elderly. Int J Vitam Nutr Res. 77:22–33. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nilsson TK, Böttiger AK, Henríquez P and Majem LS: MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. Mol Med Rep 10: 2706-2712, 2014.
APA
Nilsson, T.K., Böttiger, A.K., Henríquez, P., & Majem, L.S. (2014). MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. Molecular Medicine Reports, 10, 2706-2712. https://doi.org/10.3892/mmr.2014.2521
MLA
Nilsson, T. K., Böttiger, A. K., Henríquez, P., Majem, L. S."MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males". Molecular Medicine Reports 10.5 (2014): 2706-2712.
Chicago
Nilsson, T. K., Böttiger, A. K., Henríquez, P., Majem, L. S."MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males". Molecular Medicine Reports 10, no. 5 (2014): 2706-2712. https://doi.org/10.3892/mmr.2014.2521
Copy and paste a formatted citation
x
Spandidos Publications style
Nilsson TK, Böttiger AK, Henríquez P and Majem LS: MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. Mol Med Rep 10: 2706-2712, 2014.
APA
Nilsson, T.K., Böttiger, A.K., Henríquez, P., & Majem, L.S. (2014). MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. Molecular Medicine Reports, 10, 2706-2712. https://doi.org/10.3892/mmr.2014.2521
MLA
Nilsson, T. K., Böttiger, A. K., Henríquez, P., Majem, L. S."MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males". Molecular Medicine Reports 10.5 (2014): 2706-2712.
Chicago
Nilsson, T. K., Böttiger, A. K., Henríquez, P., Majem, L. S."MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males". Molecular Medicine Reports 10, no. 5 (2014): 2706-2712. https://doi.org/10.3892/mmr.2014.2521
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team