Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population

Wang,Rui; Zhang,Jun; Ma,Yanyun; Chen,Linqi; Guo,Shicheng; Zhang,Xiaojiao; Ma,Yunfang; Wu,Lijun; Pei,Xiaoyu; Liu,Siran; Wang,Jiucun; Hu,Heping; Liu,Jie

doi:10.3892/mmr.2014.2536

November-2014 Volume 10 Issue 5

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November-2014 Volume 10 Issue 5

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Article

Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population

Authors:
- Rui Wang
- Jun Zhang
- Yanyun Ma
- Linqi Chen
- Shicheng Guo
- Xiaojiao Zhang
- Yunfang Ma
- Lijun Wu
- Xiaoyu Pei
- Siran Liu
- Jiucun Wang
- Heping Hu
- Jie Liu
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Affiliations: Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China, Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, P.R. China
Pages: 2736-2744
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Published online on: September 4, 2014

https://doi.org/10.3892/mmr.2014.2536
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Abstract

Polymorphisms in pre‑microRNAs (miRNAs) or mature miRNAs may influence miRNA processing or target binding, thus contributing to tumorigenesis and cancer development. The present study aimed to evaluate whether miR‑149 rs2292832 (C>T) and miR‑608 rs4919510 (G>C) are associated with the risk and clinical characteristics of hepatocellular carcinoma (HCC) in a large‑scale population. miR‑149 rs2292832 and miR‑608 rs4919510 were genotyped in a total of 993 patients with HCC and 992 unrelated healthy subjects by Sequenom MassARRAY. The results showed that, compared with the reference CC genotype, the TC+TT genotype of miR‑149 was more highly associated with HCC [CC vs. TC+TT: Odds ratio (OR)=1.384, 95% confidence interval (CI)=1.013‑1.892, P=0.041], and was also associated with an increased risk of hepatitis B virus (HBV)‑associated HCC (CC vs. TC+TT: OR=1.453, 95% CI=1.034‑2.042, P=0.031). However, no significant association between miRNA‑608 rs4919510 and the risk of HCC/HBV‑associated HCC was found. In addition, these two SNPs were shown not to be correlated with a range of clinical characteristics. The present study may provide an indicator for identification of the high risk of HCC in patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population

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