|
1
|
Ding JX, Feng YJ, Yao LQ, Yu M, Jin HY and
Yin LH: The reinforcement of invasion in epithelial ovarian cancer
cells by 17 beta-estradiol is associated with upregulation of
Snail. Gynecol Oncol. 103:623–630. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Hua K, Feng W, Cao Q, Zhou X, Lu X and
Feng Y: Estrogen and progestin regulate metastasis through the
PI3K/AKT pathway in human ovarian cancer. Int J Oncol. 33:959–967.
2008.PubMed/NCBI
|
|
3
|
Hua K, Din J, Cao Q, Feng W, Zhang Y, Yao
L, Huang Y, Zhao Y and Feng Y: Estrogen and progestin regulate
HIF-1alpha expression in ovarian cancer cell lines via the
activation of Akt signaling transduction pathway. Oncol Rep.
21:893–898. 2009.PubMed/NCBI
|
|
4
|
Kong L, Schäfer G, Bu H, Zhang Y, Zhang Y
and Klocker H: Lamin A/C protein is overexpressed in
tissue-invading prostate cancer and promotes prostate cancer cell
growth, migration and invasion through the PI3K/AKT/PTEN pathway.
Carcinogenesis. 33:751–759. 2012. View Article : Google Scholar
|
|
5
|
Riggio M, Polo ML, Blaustein M,
Colman-Lerner A, Lüthy I, Lanari C and Novaro V: PI3K/AKT pathway
regulates phosphorylation of steroid receptors, hormone
independence and tumor differentiation in breast cancer.
Carcinogenesis. 33:509–518. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Huang XF and Chen JZ: Obesity, the
PI3K/AKT signal pathway and colon cancer. Obes Rev. 10:610–616.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Cantley LC, Auger KR, Carpenter C,
Duckworth B, Graziani A, Kapeller R and Soltoff S: Oncogenes and
signal transduction. Cell. 64:281–302. 1991. View Article : Google Scholar
|
|
8
|
Cantley LC and Neel BG: New insights into
tumor suppression: PTEN suppresses tumor formation by restraining
the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA.
96:4240–4245. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Yip WK and Seow HF: Activation of
phosphatidylinositol 3-kinase/AKT signaling by EGF downregulates
membranous E-cadherin and β-catenin and enhances invasion in
nasopharyngeal carcinoma cells. Cancer Lett. 318:162–172.
2012.PubMed/NCBI
|
|
10
|
Wang Y, Sheng Q, Spillman MA, Behbakht K
and Gu H: Gab2 regulates the migratory behaviors and E-cadherin
expression via activation of the PI3K pathway in ovarian cancer
cells. Oncogene. 31:2512–2520. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Shibasaki F, Fukami K, Fukui Y and
Takenawa T: Phosphatidylinositol 3-kinase binds to alpha-actinin
through the p85 subunit. Biochem J. 302:551–557. 1994.PubMed/NCBI
|
|
12
|
Ding Z, Liang J, Lu Y, Yu Q, Songyang Z,
Lin SY and Mills GB: A retrovirus-based protein complementation
assay screen reveals functional AKT1-binding partners. Proc Natl
Acad Sci USA. 103:15014–15019. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Koay MH, Crook M and Stewart CJ: Cyclin
D1, E-cadherin and beta-catenin expression in FIGO Stage IA
cervical squamous carcinoma: diagnostic value and evidence for
epithelial-mesenchymal transition. Histopathology. 61:1125–1133.
2012. View Article : Google Scholar
|
|
14
|
Xiong H, Hong J, Du W, Lin YW, Ren LL,
Wang YC, Su WY, Wang JL, Cui Y, Wang ZH and Fang JY: Roles of STAT3
and ZEB1 proteins in E-cadherin down-regulation and human
colorectal cancer epithelial-mesenchymal transition. J Biol Chem.
287:5819–5832. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lombaerts M, van Wezel T, Philippo K,
Dierssen JW, Zimmerman RM, Oosting J, van Eijk R, Eilers PH, van de
Water B, Cornelisse CJ and Cleton-Jansen AM: E-cadherin
transcriptional downregulation by promoter methylation but not
mutation is related to epithelial-to-mesenchymal transition in
breast cancer cell lines. Br J Cancer. 94:661–671. 2006.
|
|
16
|
Gravdal K, Halvorsen OJ, Haukaas SA and
Akslen LA: A switch from E-cadherin to N-cadherin expression
indicates epithelial to mesenchymal transition and is of strong and
independent importance for the progress of prostate cancer. Clin
Cancer Res. 13:7003–7011. 2007. View Article : Google Scholar
|
|
17
|
Lau MT, Klausen C and Leung PC: E-cadherin
inhibits tumor cell growth by suppressing PI3K/AKT signaling via
β-catenin-Egr1-mediated PTEN expression. Oncogene. 30:2753–2766.
2011.PubMed/NCBI
|
|
18
|
Cheng JC, Auersperg N and Leung PC:
Inhibition of p53 induces invasion of serous borderline ovarian
tumor cells by accentuating PI3K/Akt-mediated suppression of
E-cadherin. Oncogene. 30:1020–1031. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Pearce ST and Jordan VC: The biological
role of estrogen receptors alpha and beta in cancer. Crit Rev Oncol
Hematol. 50:3–22. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Park SH, Cheung LW, Wong AS and Leung PC:
Estrogen regulates Snail and Slug in the down-regulation of
E-cadherin and induces metastatic potential of ovarian cancer cells
through estrogen receptor alpha. Mol Endocrinol. 22:2085–2098.
2008. View Article : Google Scholar
|
|
21
|
Kohn EC and Liotta LA: Molecular insights
into cancer invasion: strategies for prevention and intervention.
Cancer Res. 55:1856–1862. 1995.PubMed/NCBI
|
|
22
|
Brustmann H and Naudé S: Expression of
nm23 in normal, hyperplastic and neoplastic endometrial tissues.
Pathol Res Pract. 195:829–834. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Chen XF, Zhang HT, Qi QY, Sun MM and Tao
LY: Expression of E-cadherin and nm23 is associated with the
clinicopathological factors of human non-small cell lung cancer in
China. Lung Cancer. 48:69–76. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Ohta S, Lai EW, Pang AL, Brouwers FM, Chan
WY, Eisenhofer G, de Krijger R, Ksinantova L, Breza J, Blazicek P,
Kvetnansky R, Wesley RA and Pacak K: Downregulation of metastasis
suppressor genes in malignant pheochromocytoma. Int J Cancer.
114:139–143. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Bellacosa A, de Feo D, Godwin AK, Bell DW,
Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V,
Ferrandina G, Benedetti Panici P, Mancuso S, Neri G and Testa JR:
Molecular alterations of the AKT2 oncogene in ovarian and breast
carcinomas. Int J Cancer. 64:280–285. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X,
Jiang C, Coppola D, Nicosia SV and Cheng JQ: Frequent activation of
AKT2 and induction of apoptosis by inhibition of
phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer.
Oncogene. 19:2324–2330. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Altomare DA, Wang HQ, Skele KL, De Rienzo
A, Klein-Szanto AJ, Godwin AK and Testa JR: AKT and mTOR
phosphorylation is frequently detected in ovarian cancer and can be
targeted to disrupt ovarian tumor cell growth. Oncogene.
23:5853–5857. 2004. View Article : Google Scholar
|
