Open Access

Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells

  • Authors:
    • Meng Zhang
    • Zhi-Gang Bian
    • Yi Zhang
    • Jia-He Wang
    • Liang Kan
    • Xin Wang
    • Hui-Yan Niu
    • Ping He
  • View Affiliations

  • Published online on: September 18, 2014     https://doi.org/10.3892/mmr.2014.2581
  • Pages: 2905-2911
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Natural products are a great source of cancer chemotherapeutic agents. The present study was conducted to investigate whether cucurbitacin B (CuB), one of the most potent and widely used cucurbitacins, inhibits proliferation and induces apoptosis in the A549 lung cancer cell line. Furthermore, CuB induced apoptosis of A549 cells in a ­concentration-dependent manner, as determined by fluorescence microscopy, flow cytometry and transmission electron microscopy. The present study also demonstrated that CuB dose-dependently inhibited lung cancer cell proliferation, with cell cycle inhibition and cyclin B1 downregulation. Apoptosis induced by CuB was shown to be associated with cytochrome c release, B-cell lymphoma 2 downregulation and signal transducer and activator of transcription 3 pathway inhibition. CuB may prove to be a useful approach for the chemotherapy of lung cancer.
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December-2014
Volume 10 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos
Zhang M, Bian Z, Zhang Y, Wang J, Kan L, Wang X, et al: Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Mol Med Rep 10: 2905-2911, 2014
APA
Zhang, M., Bian, Z., Zhang, Y., Wang, J., Kan, L., Wang, X. ... He, P. (2014). Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Molecular Medicine Reports, 10, 2905-2911. https://doi.org/10.3892/mmr.2014.2581
MLA
Zhang, M., Bian, Z., Zhang, Y., Wang, J., Kan, L., Wang, X., Niu, H., He, P."Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells". Molecular Medicine Reports 10.6 (2014): 2905-2911.
Chicago
Zhang, M., Bian, Z., Zhang, Y., Wang, J., Kan, L., Wang, X., Niu, H., He, P."Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells". Molecular Medicine Reports 10, no. 6 (2014): 2905-2911. https://doi.org/10.3892/mmr.2014.2581