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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2014 Volume 10 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Hepatocyte growth factor activator inhibitor type‑1 in cancer: Advances and perspectives (Review)

Qiaoli Zheng, Haijian Wu, Jiang Cao, Jingjia Ye
Pages: 2779-2785
Published online on: 13 October 2014

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Article Open Access

Genistein decreases cellular redox potential, partially suppresses cell growth in HL‑60 leukemia cells and sensitizes cells to γ‑radiation‑induced cell death

In Gyu Kim, Jin Sik Kim, Jae Ha Lee, Eun Wie Cho
Pages: 2786-2792
Published online on: 08 October 2014

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Article Open Access

Proteome changes in mesenteric lymph induced by sepsis

Ping Zhang, Yan Li, Lian‑Dong Zhang, Liang‑Hua  Wang, Xi Wang, Chao He, Zhao‑Fen Lin
Pages: 2793-2804
Published online on: 18 September 2014

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Article Open Access

Nicotinic acid modulates intracellular calcium concentration and disassembles the cytoskeleton

Jiejing Li, Yanxi Li, Penghui Zhang, Hua Niu, Yu Shi
Pages: 2805-2810
Published online on: 18 September 2014

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Article

Coxsackievirus B detection in cases of myocarditis, myopericarditis, pericarditis and dilated cardiomyopathy in hospitalized patients

Imed Gaaloul, Samira Riabi, Rafik Harrath, Timothy Hunter, Khaldoun B. Hamda, Assia B. Ghzala, Sally Huber, Mahjoub Aouni
Pages: 2811-2818
Published online on: 18 September 2014

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Article Open Access

Increased production of suilysin contributes to invasive infection of the Streptococcus suis strain 05ZYH33

Zhengxin He, Yaya Pian, Zhiqiang Ren, Lili Bi, Yuan Yuan, Yuling Zheng, Yongqiang Jiang, Fukun Wang
Pages: 2819-2826
Published online on: 22 September 2014

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Article Open Access

Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes

Bohan Dong, Guangli Dai, Lei Xu, Yao Zhang, Liefeng Ling, Lingling Sun, Jun Lv
Pages: 2827-2834
Published online on: 02 October 2014

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Article Open Access

Low-magnitude high-frequency loading, by whole-body vibration, accelerates early implant osseointegration in ovariectomized rats

Yong-Qiang Liang, Meng-Chun Qi, Jiang Xu, Juan Xu, Hua-Wei Liu, Wei Dong, Jin-Yuan Li, Min Hu
Pages: 2835-2842
Published online on: 23 September 2014

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Article Open Access

Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo

Xuezhen Li, Xin He, Wei Tian, Jianzhen Wang
Pages: 2843-2850
Published online on: 15 October 2014

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Article Open Access

Insights into the paracrine effects of uterine natural killer cells

Xin Gong, Yanxia Liu, Zhenzhen Chen, Cai Xu, Qiudan Lu, Zhe Jin
Pages: 2851-2860
Published online on: 13 October 2014

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Article Open Access

D‑galactose‑induced mitochondrial DNA oxidative damage in the auditory cortex of rats

Zhengde Du, Qiong Yang, Tao Zhou, Lin Liu, Shuo Li, Shixiong Chen, Chunsheng Gao
Pages: 2861-2867
Published online on: 15 October 2014

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Article Open Access

Protein-protein interaction analysis of distinct molecular pathways in two subtypes of colorectal carcinoma

Hanzhang Chen, Yunzhen Fang, Hailong Zhu, Shuai Li, Tao Wang, Pan Gu, Xia Fang, Yunjin Wu, Jun Liang, Yu Zeng, Long Zhang, Weizhe Qiu, Lanjing Zhang, Xianghua Yi
Pages: 2868-2874
Published online on: 22 September 2014

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Article Open Access

Ischemic postconditioning prevents renal ischemia reperfusion injury through the induction of heat shock proteins in rats

Qiongmei Guo, Xuefang Du, Yanli Zhao, Dong Zhang, Lihui Yue, Zhenxian Wang
Pages: 2875-2881
Published online on: 14 October 2014

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Article Open Access

Inducing human parthenogenetic embryonic stem cells into islet‑like clusters

Jin Li, Jingjing He, Ge Lin, Guangxiu Lu
Pages: 2882-2890
Published online on: 22 September 2014

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Article Open Access

Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel‑7402/5‑fluorouracil cells Corrigendum in /10.3892/mmr.2022.12691

Sunbin Ling, Yu Tian, Haiquan Zhang, Kaiqi Jia, Tingting Feng, Deguang Sun, Zhenming Gao, Fei Xu, Zhaoyuan Hou, Yan Li, Liming Wang
Pages: 2891-2897
Published online on: 08 October 2014

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Article Open Access

Effects of gastrokine‑2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways

Lin‑Sen Shi, Hao Wang, Feng Wang, Min Feng, Meng Wang, Wen‑Xian Guan
Pages: 2898-2904
Published online on: 30 September 2014

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Article Open Access

Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells

Meng Zhang, Zhi-Gang Bian, Yi Zhang, Jia-He Wang, Liang Kan, Xin Wang, Hui-Yan Niu, Ping He
Pages: 2905-2911
Published online on: 18 September 2014

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Article Open Access

A polymorphism site in the pre‑miR‑34a coding region reduces miR‑34a expression and promotes osteosarcoma cell proliferation and migration

Honglin Lv, Jingfang Pei, Hongtao Liu, Haiyan Wang, Jun Liu
Pages: 2912-2916
Published online on: 18 September 2014

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Article Open Access

Ezetimibe prevents the development of non‑alcoholic fatty liver disease induced by high‑fat diet in C57BL/6J mice

Xiang Wang, Qiaohua Ren, Tao Wu, Yong Guo, Yong Liang, Subo Liu
Pages: 2917-2923
Published online on: 10 October 2014

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Article

Voluntary wheel running ameliorates symptoms of MK-801-induced schizophrenia in mice

Tae-Woon Kim, Hyun-Sik Kang, Joon-Ki Park, Sam-Jun Lee, Sang-Bin Baek, Chang-Ju Kim
Pages: 2924-2930
Published online on: 15 October 2014

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Article

Caffeine enhances micturition through neuronal activation in micturition centers

Young‑Sam Cho, Il‑Gyu Ko, Sung‑Eun Kim, Lakkyong Hwan, Mal‑Soon Shin, Chang‑Ju  Kim, Sang‑Hoon Kim, Jun‑Jang Jin, Jun‑Young Chung, Khae‑Hawn Kim
Pages: 2931-2936
Published online on: 15 October 2014

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Article

Characterization of sphere‑forming cells with stem‑like properties from the gastric cancer cell lines MKN45 and SGC7901

Xuming Wang, Feng Zou, Hao Deng, Zhengqi Fu, Yan Li, Lixia Wu, Zhaoyi Wang, Lijiang Liu
Pages: 2937-2941
Published online on: 26 September 2014

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Article

Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint

Xingxiao Gao, Peng Sun, Mingqi Qiao, Sheng Wei, Ling Xue, Huiyun Zhang
Pages: 2942-2948
Published online on: 26 September 2014

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Article

Analysis of DAZL SNP260 and SNP386 in infertile Chinese males using multi-analyte suspension array

Yijian Zhu, Mingfu Ma, Ling Wan, Danyan Zhang, Letian Zhao, Li Wei, Lianbing Li
Pages: 2949-2954
Published online on: 14 October 2014

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Article

Effects of small interfering RNA interference of connexin 37 on subcutaneous gastric tumours in mice

Yuanming Jing, Suxia Guo, Xiaoping Zhang, Aijing  Sun, Feng Tao, Haixing Ju, Haixin Qian
Pages: 2955-2960
Published online on: 08 October 2014

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Article

N‑acetyl‑L‑cysteine reduces arsenite‑induced cytotoxicity through chelation in U937 monocytes and macrophages

Sidra Ghani, Noureen Khan, Chihaya Koriyama, Suminori Akiba, Megumi Yamamoto
Pages: 2961-2966
Published online on: 08 October 2014

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Article

LY294002 suppresses the malignant phenotype and sensitizes osteosarcoma cells to pirarubicin chemotherapy

Xin Hua Long, Zhen Hao Zhong, Ai Fen Peng, Liang  Bo Zhu, Heng Wang, Guo Mei Zhang, Zhi Li Liu
Pages: 2967-2972
Published online on: 09 October 2014

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Article

Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma

Yunling Dou, Jiaping Lin, Haihua Shu, Nan Jiang
Pages: 2973-2978
Published online on: 22 September 2014

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Article

Erythropoietin promotes retinal angiogenesis in a mouse model

Chen-Ting Wen, Tao He, Yi-Qiao Xing
Pages: 2979-2984
Published online on: 23 September 2014

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Article

Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in osteosarcoma cells

Tao Feng, Guanglei Qiao, Li Feng, Weixiang Qi, Yujing Huang, Yang Yao, Zan Shen
Pages: 2985-2992
Published online on: 09 October 2014

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Article

Dual matrilineal geographic distribution of Korean type 2 diabetes mellitus-associated -11,377 G adiponectin allele

Jee-Hye Choi, Na Young Min, Sang Kil Park, Lkhagvasuren Gavaachimed, Young  Jong Ko, Sung Hoon Han, Kyung Yong Kim, Kijung Kim, Kwang Ho Lee, Ae Ja Park
Pages: 2993-3002
Published online on: 14 October 2014

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Article

Inhibition of autophagy alleviates the senescent state of rat mesenchymal stem cells during long-term culture

Yong Zheng, Cheng-Jun Hu, Ru-Hong Zhuo, Yue-Shan Lei, Na-Na Han, Liu He
Pages: 3003-3008
Published online on: 10 October 2014

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Article

Crotoxin suppresses the tumorigenic properties and enhances the antitumor activity of Iressa® (gefinitib) in human lung adenocarcinoma SPCA‑1 cells

Junhua Wang, Xiuguang Qin, Zhiqiang Zhang, Meiling Chen, Ying Wang, Baoqin Gao
Pages: 3009-3014
Published online on: 09 October 2014

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Article

Effect of triptolide on the regulation of ATP‑binding cassette transporter A1 expression in lipopolysaccharide‑induced acute lung injury of rats

Jun Chen, Jianlin Gao, Jianping Yang, Yukun Zhang, Lina Wang
Pages: 3015-3020
Published online on: 14 October 2014

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Article

Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line

Ying Wu, Jing Wang, Hong Zhou, Xiaoyan Yu, Lichao Hu, Fanlu Meng, Shuanghong Jiang
Pages: 3021-3026
Published online on: 15 October 2014

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Article

Enhancement of the effects of gemcitabine against pancreatic cancer by oridonin via the mitochondrial caspase-dependent signaling pathway

Dian-Lei Liu, He-Qi Bu, Hai-Min Jin, Jin-Feng Zhao, Ye Li, Hai Huang
Pages: 3027-3034
Published online on: 19 September 2014

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Article

Inhibitory activity of Socheongryong‑tang and its constituent components against the production of RANTES, eotaxin, eotaxin‑3 and MMP‑9 from BEAS‑2B cells

Jung-Hoon Kim, Woo‑Young Jeon, Mee‑Young Lee, Chang‑Seob  Seo, Hye‑Sun Lim, Hyeun‑Kyoo Shin
Pages: 3035-3046
Published online on: 14 October 2014

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Article

Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic‑ischemic brain injury by up‑regulating brain‑derived neurotrophic factor

Jin Sun, Yunxia Qu, Huiming He, Xiaolei Fan, Yuanhua Qin, Weifeng Mao, Lixin Xu
Pages: 3047-3051
Published online on: 18 September 2014

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Article

Dual specificity phosphatase 6 suppresses the growth and metastasis of prostate cancer cells

Xiaolei Zhai, Qianhe Han, Zhongjie Shan, Xiaowei Qu, Liang Guo, Yudong Zhou
Pages: 3052-3058
Published online on: 18 September 2014

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Article

Expression of the Annexin A1 gene is associated with suppression of growth, invasion and metastasis of nasopharyngeal carcinoma

Aifeng Liu, Weiguo Huang, Guqing Zeng, Xiaohua Ma, Xiao Zhou, Yafei Wang, Chenjie Ouyang, Ailan Cheng
Pages: 3059-3067
Published online on: 15 October 2014

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Article

Adipose-derived stem cells promote human dermal fibroblast function and increase senescence-associated β‑galactosidase mRNA expression through paracrine effects

Xiao Shen, Yunpeng Du, Weimin Shen, Bin Xue, Yu Zhao
Pages: 3068-3072
Published online on: 13 October 2014

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Article

MicroRNA-214 regulates osteosarcoma survival and growth by directly targeting phosphatase and tensin homolog

Xuming Wang, Jiabing Sun, Chunjiang Fu, Dewei Wang, Zhenggang Bi
Pages: 3073-3079
Published online on: 09 October 2014

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Article

Upregulated microRNA-199a-5p inhibits nuclear receptor corepressor 1 translation in mice with non‑alcoholic steatohepatitis

Binggui Zhang, Rongqi Wang, Jinghua Du, Jingya Niu, Rui Zhang, Shunjiang Xu, Xuemin Niu, Qingfu Zhang, Yuemin Nan
Pages: 3080-3086
Published online on: 23 September 2014

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Article

Screening candidate genes associated with bladder cancer using DNA microarray

Axiang Xu, Chunyang Wang, Shengkun Sun
Pages: 3087-3091
Published online on: 15 October 2014

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Article

Effects and mechanism of downregulation of COX‑2 expression by RNA interference on proliferation and apoptosis of human breast cancer MCF‑7 cells

Hui Han, Sheng Yang, Shun‑Guo Lin, Chun‑Sen Xu, Zhong‑Hua Han
Pages: 3092-3098
Published online on: 15 October 2014

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Article

Upregulation of forkhead box O3 transcription is involved in C2-ceramide induced apoptosis and autophagy in ovarian cancer cells in vitro

Zhishan Jin, Lang Zheng, Xiaoyan Xin, Yuanyue Li, Teng Hua, Tingting Wu, Hongbo Wang
Pages: 3099-3105
Published online on: 15 October 2014

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Article

Serum amyloid A promotes osteosarcoma invasion via upregulating αvβ3 integrin

Peng Ren, Deshun Sun, Dajiang Xin, Wanli Ma, Peng Chen, Hongwei Gao, Shouqiang Zhang, Mingzhi Gong
Pages: 3106-3112
Published online on: 14 October 2014

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Article

Modulation of hepatitis B surface antigen secretion by annexin II expressed in hepatitis B virus‑producing hepatoma cells

Yaming Liu, Pujun Gao
Pages: 3113-3117
Published online on: 30 September 2014

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Article

Preliminary screening of differentially expressed circulating microRNAs in patients with steroid‑induced osteonecrosis of the femoral head

Xingshan Wang, Wenwei Qian, Zhihong Wu, Yanyan Bian, Xisheng Weng
Pages: 3118-3124
Published online on: 15 October 2014

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Article

Inhibition of hepatocellular carcinoma by fulvestrant involves the estrogen receptor α and Wnt pathways in vitro and in patients

Cong-Jun Wang, De-Kai Guo, Tian-Geng You, Dong-Wei Shen, Chao  Wang, Lin Tang, Jian Wang, Rong-Hua Xu, Hui Zhang
Pages: 3125-3131
Published online on: 23 September 2014

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Article

Berberine sensitizes rapamycin‑mediated human hepatoma cell death in vitro

Na Guo, Aili Yan, Xingchun Gao, Yanke Chen, Xinying  He, Zhifang Hu, Man Mi, Xu Tang, Xingchun Gou
Pages: 3132-3138
Published online on: 08 October 2014

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Article

Function of Hsf1 in SV40 T‑antigen‑transformed HEK293T cells

Qiying Jiang, Zhi Zhang, Yanzhong Hu, Yuanfang Ma
Pages: 3139-3144
Published online on: 09 October 2014

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Article

14-3-3ε functions as an oncogene in SGC7901 gastric cancer cells through involvement of cyclin E and p27kip1

Xiaoxiang Gong, Lu Yan, Huan Gu, Yibing Mu, Gele Tong, Guiying Zhang
Pages: 3145-3150
Published online on: 02 October 2014

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Article

Polymorphism of the SRD5A2 gene and the risk of prostate cancer

Róbert Dušenka, Roman Tomaškin, Ján Kliment, Dušan Dobrota, Svetlana Dušenková, Marta Vilčková, Monika Kmeť'ová Sivoňová
Pages: 3151-3156
Published online on: 10 October 2014

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Article

Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats

Haiying Zhang, Ning Li, Kun Li, Peng Li
Pages: 3157-3162
Published online on: 08 October 2014

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Article

Investigation of MEK activity in COS7 cells entering mitosis

Huaiping Shi, Tianying Zhang, Yongqing Yi, Jun Luo
Pages: 3163-3168
Published online on: 22 September 2014

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Article

Sox2 is involved in paclitaxel resistance of the prostate cancer cell line PC-3 via the PI3K/Akt pathway

Dong Li, Li-Nan Zhao, Xiu-Lan Zheng, Ping Lin, Feng Lin, Yue Li, Hai‑Feng Zou, Rong-Jun Cui, Hui Chen, Xiao-Guang Yu
Pages: 3169-3176
Published online on: 13 October 2014

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Article

Silencing of the glypican-3 gene affects the biological behavior of human hepatocellular carcinoma cells

Xin-Hui Qi, Di Wu, Hui-Xia Cui, Nan Ma, Jia Su, Yu-Tong Wang, You-Hong Jiang
Pages: 3177-3184
Published online on: 26 September 2014

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Article

Inhibition of glycogen synthase kinase-3β attenuates acute kidney injury in sodium taurocholate‑induced severe acute pancreatitis in rats

Kailiang Zhao, Chen Chen, Qiao Shi, Wenhong Deng, Teng Zuo, Xiaobo He, Tianyi Liu, Liang Zhao, Weixing Wang
Pages: 3185-3192
Published online on: 15 October 2014

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Article

Effects of metformin on FOXM1 expression and on the biological behavior of acute leukemia cell lines

Bing Zhang, Long-Long Liu, Xia Mao, Dong-Hua Zhang
Pages: 3193-3198
Published online on: 13 October 2014

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Article

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway

Jiangbo Yu, Shusen Yang, Xu Wang, Runtao Gan
Pages: 3199-3204
Published online on: 14 October 2014

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Article

JNK1‑mediated phosphorylation of Smac/DIABLO at the serine 6 residue is functionally linked to its mitochondrial release during TNF‑α­‑induced apoptosis of HeLa cells

Byoungduck Park
Pages: 3205-3210
Published online on: 13 October 2014

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Article

Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells

Rong-Fei Han, Kai Li, Zi-Shan Yang, Zhi-Guo Chen, Wan-Cai Yang
Pages: 3211-3216
Published online on: 23 September 2014

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Effects of an adenoviral vector containing a suicide gene fusion on growth characteristics of breast cancer cells

Heng Kong, Chunli Liu, Ting Zhu, Zonghai Huang, Liucheng Yang, Qiang Li
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Investigation of the effect of nocodazole on the PI3K/Akt signaling pathway in COS7 cells

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Esculetin suppresses lipopolysaccharide-induced inflammatory mediators and cytokines by inhibiting nuclear factor-κB translocation in RAW 264.7 macrophages

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Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response

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Effects of individual and multiple fatty acids (palmitate, oleate and docosahaexenoic acid) on cell viability and lipid metabolism in LO2 human liver cells

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The protective effect of curcumin against the 19‑kDa Mycobacterium tuberculosis protein-induced inflammation and apoptosis in human macrophages

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Role and mechanisms of microRNA‑503 in drug resistance reversal in HepG2/ADM human hepatocellular carcinoma cells

Dong Wang, Nan Zhang, Yintao Ye, Junqiang Qian, Yu Zhu, Chen Wang
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Inhibition of the p38 MAPK pathway sensitizes human gastric cells to doxorubicin treatment in vitro and in vivo

Wei Tan, Hong-Gang Yu, He-Sheng Luo
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Low-frequency low energy ultrasound combined with microbubbles induces distinct apoptosis of A7r5 cells

Bo Zhang, Hongsheng Zhou, Qian Cheng, Lei Lei, Bing Hu
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Restoration of microRNA‑218 increases cellular chemosensitivity to cervical cancer by inhibiting cell‑cycle progression

Ruofan Dong, Haifeng Qiu, Guiqiang Du, Yuan Wang, Jinjin Yu, Caiping Mao
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Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice

Huan Gong, Jing Pang, Yiwen Han, Yang Dai, Dapeng Dai, Jianping Cai, Tie-Mei Zhang
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MicroRNA‑224 is downregulated in mucinous cystic neoplasms of the pancreas and may regulate tumorigenesis by targeting Jagged1

Beibei Zhang, Xiaorong Guo, Jingxi Zhang, Xiao Liu, Xianbao Zhan, Zhaoshen Li
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MicroRNA-16 suppresses epithelial-mesenchymal transition‑related gene expression in human glioma

Qin Wang, Xu Li, Yu Zhu, Ping Yang
Pages: 3310-3314
Published online on: 19 September 2014

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Effects of Asiasari radix on the morphology and viability of mesenchymal stem cells derived from the gingiva

Su‑Hyeon Jeong, Ji‑Eun Lee, Seong-Ho Jin, Youngkyung Ko, Jun-Beom Park
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Quercetin reversed lipopolysaccharide-induced inhibition of osteoblast differentiation through the mitogen‑activated protein kinase pathway in MC3T3-E1 cells

Xin-Chun Wang, Nzhi-Jun Zhao, Chun Guo, Jing-Tao Chen, Jin-Ling Song, Li Gao
Pages: 3320-3326
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Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats

Xia Li, Can He, Wang‑Yang Wu, Huan Huang, Wei‑Zu Li, Yan‑Yan Yin
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Inhibition of the invasion and migration of renal carcinoma 786‑o‑si3 cells in vitro and in vivo by Koelreuteria formosana extract

Chin‑Yin Lin, Pei‑Ni Chen, Li‑Sung Hsu, Dong Yih Kuo, Shu‑Chen Chu, Yih‑Shou Hsieh
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USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A

Jianjun Xiong, Xiaoyuan Xu, Xiaou Zhou, Jianyun  Liu, Zhen Gong, Ping Wu, Weidong Li
Pages: 3343-3347
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Bioinformatic mining of kinase inhibitors that regulate autophagy through kinase signaling pathways

Yang Yang, Biao Ma, Ye Jin, Wei Ben, Dandan Zhang, Keping  Jiang, Shujun Feng, Lu Huang, Jianhua Zheng
Pages: 3348-3356
Published online on: 15 October 2014

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

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Article Number: 50
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
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Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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