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Article

Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats

  • Authors:
    • Xia Li
    • Can He
    • Wang‑Yang Wu
    • Huan Huang
    • Wei‑Zu Li
    • Yan‑Yan Yin
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Anhui Medical University, Hefei, Anhui 230032, P.R. China
  • Pages: 3327-3333
    |
    Published online on: September 30, 2014
       https://doi.org/10.3892/mmr.2014.2604
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Abstract

Acremoniumterricola milleretal mycelium (AMM) exerts numerous protective effects on organs, and has been used in Chinese herb prescriptions to treat refractory diseases. The aim of this study was to investigate the effects of AMM on immunological hepatic fibrosis induced by porcine serum (PS) in rats. Male Sprague Dawley rats were administered 0.5 ml sterile PS by intraperitoneal injections twice a week for 18 weeks. AMM (175, 350 or 700 mg/kg) and colchicine (0.1 mg/kg) were administered intragastrically each day until the rats were sacrificed. PS administration resulted in marked hepatic fibrosis, as assessed by increased oxidative stress and hepatic collagen content, as well as α‑smooth muscle actin (α‑SMA) expression. AMM significantly reduced liver damage and fibrosis. In addition, AMM decreased the elevation in hydroxyproline, hyaluronic acid, laminin and procollagen type III; increased the activity of superoxide dismutase and glutathione peroxidase; decreased α‑SMA expression; and eliminated hepatic collagen deposits. Furthermore, AMM inhibited Smad2/3 phosphorylation and Smad7 expression. These results indicate that AMM is able to reduce oxidative stress, inhibit collagen synthesis and block the transforming growth factor‑β/Smad signaling pathway in a dose‑dependent manner.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, He C, Wu WY, Huang H, Li WZ and Yin YY: Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats. Mol Med Rep 10: 3327-3333, 2014.
APA
Li, X., He, C., Wu, W., Huang, H., Li, W., & Yin, Y. (2014). Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats. Molecular Medicine Reports, 10, 3327-3333. https://doi.org/10.3892/mmr.2014.2604
MLA
Li, X., He, C., Wu, W., Huang, H., Li, W., Yin, Y."Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats". Molecular Medicine Reports 10.6 (2014): 3327-3333.
Chicago
Li, X., He, C., Wu, W., Huang, H., Li, W., Yin, Y."Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats". Molecular Medicine Reports 10, no. 6 (2014): 3327-3333. https://doi.org/10.3892/mmr.2014.2604
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, He C, Wu WY, Huang H, Li WZ and Yin YY: Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats. Mol Med Rep 10: 3327-3333, 2014.
APA
Li, X., He, C., Wu, W., Huang, H., Li, W., & Yin, Y. (2014). Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats. Molecular Medicine Reports, 10, 3327-3333. https://doi.org/10.3892/mmr.2014.2604
MLA
Li, X., He, C., Wu, W., Huang, H., Li, W., Yin, Y."Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats". Molecular Medicine Reports 10.6 (2014): 3327-3333.
Chicago
Li, X., He, C., Wu, W., Huang, H., Li, W., Yin, Y."Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats". Molecular Medicine Reports 10, no. 6 (2014): 3327-3333. https://doi.org/10.3892/mmr.2014.2604
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