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Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes

  • Authors:
    • Bohan Dong
    • Guangli Dai
    • Lei Xu
    • Yao Zhang
    • Liefeng Ling
    • Lingling Sun
    • Jun Lv
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Wannan Medical College, Wuhu, Anhui 241002, P.R. China, Department of Gynaecology and Obstetrics, Traditional Chinese Medical Hospital of Wuhu, Wuhu, Anhui 241000, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2827-2834
    |
    Published online on: October 2, 2014
       https://doi.org/10.3892/mmr.2014.2606
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Abstract

Although tumor cell lysate (TCL) is a type of immunocyte stimulator, its immunosuppressive function must not be ignored. The present study reported that TCL prepared from a Lewis lung cancer cell was able to induce the development of immunosuppressive macrophages (MΦ) and tolerogenic dendritic cells. In addition, TCL upregulated the expression of CD69 in mouse splenocytes, and cell apoptosis and the percentage of regulatory T cells in mouse splenocytes simultaneously increased. Furthermore, the present study found that the immunosuppressive factor, hyaluronan, and the apoptosis inducers, Fas ligand and transforming growth factor-β, are present in TCL. These components may be associated with the emergence of immunosuppressive cells or splenocyte apoptosis. Thus, the present study has enriched our understanding of the composition of TCL and its negative regulatory effect on immunocytes.
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Copy and paste a formatted citation
Spandidos Publications style
Dong B, Dai G, Xu L, Zhang Y, Ling L, Sun L and Lv J: Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes. Mol Med Rep 10: 2827-2834, 2014.
APA
Dong, B., Dai, G., Xu, L., Zhang, Y., Ling, L., Sun, L., & Lv, J. (2014). Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes. Molecular Medicine Reports, 10, 2827-2834. https://doi.org/10.3892/mmr.2014.2606
MLA
Dong, B., Dai, G., Xu, L., Zhang, Y., Ling, L., Sun, L., Lv, J."Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes". Molecular Medicine Reports 10.6 (2014): 2827-2834.
Chicago
Dong, B., Dai, G., Xu, L., Zhang, Y., Ling, L., Sun, L., Lv, J."Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes". Molecular Medicine Reports 10, no. 6 (2014): 2827-2834. https://doi.org/10.3892/mmr.2014.2606
Copy and paste a formatted citation
x
Spandidos Publications style
Dong B, Dai G, Xu L, Zhang Y, Ling L, Sun L and Lv J: Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes. Mol Med Rep 10: 2827-2834, 2014.
APA
Dong, B., Dai, G., Xu, L., Zhang, Y., Ling, L., Sun, L., & Lv, J. (2014). Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes. Molecular Medicine Reports, 10, 2827-2834. https://doi.org/10.3892/mmr.2014.2606
MLA
Dong, B., Dai, G., Xu, L., Zhang, Y., Ling, L., Sun, L., Lv, J."Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes". Molecular Medicine Reports 10.6 (2014): 2827-2834.
Chicago
Dong, B., Dai, G., Xu, L., Zhang, Y., Ling, L., Sun, L., Lv, J."Tumor cell lysate induces the immunosuppression and apoptosis of mouse immunocytes". Molecular Medicine Reports 10, no. 6 (2014): 2827-2834. https://doi.org/10.3892/mmr.2014.2606
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