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Article

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway

  • Authors:
    • Jiangbo Yu
    • Shusen Yang
    • Xu Wang
    • Runtao Gan
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
  • Pages: 3199-3204
    |
    Published online on: October 14, 2014
       https://doi.org/10.3892/mmr.2014.2642
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Abstract

Matrine, an alkaloid isolated from the traditional Chinese medicine Sophora flavescens AIT has exhibited a number of therapeutic effects on cardiovascular and liver diseases. The purpose of the present study was to investigate whether matrine has a protective effect on heart failure in rats. Coronary artery ligation was used to induce a heart failure (CHF) model in rats. Four weeks following the procedure, the rats were treated with different doses of matrine for one month. Histopathological examination demonstrated that matrine treatment alleviated myocardial hypertrophy and cardiac fibrosis in failing hearts. Furthermore, matrine administration also inhibited the increase of plasma aspartate amino transferase, creatine phosphokinase and lactate dehydrogenase levels in CHF rats. The rats with heart failure exhibited a significant reduction in ejection fraction and fractional shortening, as well as an increase in the left ventricular end systolic dimension, and matrine attenuated this decline in heart function. Further investigation demonstrated that matrine treatment also inhibited the upregulation of Bax and increase in the Bcl‑2 expression in the failing hearts. Furthermore, the upregulation of β3-adrenoreceptor (AR) and endothelial nitric oxide synthase proteins following heart failure were also attenuated by matrine. In conclusion, matrine had a preventive role in heart failure in rats at least in part by inhibiting myocardial apoptosis and the β3-AR pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Yang S, Wang X and Gan R: Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway. Mol Med Rep 10: 3199-3204, 2014.
APA
Yu, J., Yang, S., Wang, X., & Gan, R. (2014). Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway. Molecular Medicine Reports, 10, 3199-3204. https://doi.org/10.3892/mmr.2014.2642
MLA
Yu, J., Yang, S., Wang, X., Gan, R."Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway". Molecular Medicine Reports 10.6 (2014): 3199-3204.
Chicago
Yu, J., Yang, S., Wang, X., Gan, R."Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway". Molecular Medicine Reports 10, no. 6 (2014): 3199-3204. https://doi.org/10.3892/mmr.2014.2642
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Yang S, Wang X and Gan R: Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway. Mol Med Rep 10: 3199-3204, 2014.
APA
Yu, J., Yang, S., Wang, X., & Gan, R. (2014). Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway. Molecular Medicine Reports, 10, 3199-3204. https://doi.org/10.3892/mmr.2014.2642
MLA
Yu, J., Yang, S., Wang, X., Gan, R."Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway". Molecular Medicine Reports 10.6 (2014): 3199-3204.
Chicago
Yu, J., Yang, S., Wang, X., Gan, R."Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway". Molecular Medicine Reports 10, no. 6 (2014): 3199-3204. https://doi.org/10.3892/mmr.2014.2642
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