Bioinformatic mining of kinase inhibitors that regulate autophagy through kinase signaling pathways

Yang,Yang; Ma,Biao; Jin,Ye; Ben,Wei; Zhang,Dandan; Jiang,Keping; Feng,Shujun; Huang,Lu; Zheng,Jianhua

doi:10.3892/mmr.2014.2663

Bioinformatic mining of kinase inhibitors that regulate autophagy through kinase signaling pathways

Authors:
- Yang Yang
- Biao Ma
- Ye Jin
- Wei Ben
- Dandan Zhang
- Keping Jiang
- Shujun Feng
- Lu Huang
- Jianhua Zheng
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Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
Published online on: October 15, 2014 https://doi.org/10.3892/mmr.2014.2663
Pages: 3348-3356

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Abstract

The aim of this study was to predict the kinase inhibitors that may regulate autophagy. A total of 62 kinases were obtained through text mining by importing the keyword ‘autophagy’ and a ‘protein kinase’ Excel file to PubMed. Subsequently, 146 kinases were derivated through screening in the PubMed database by importing the ‘autophagy‑associated gene’ and ‘protein kinase’ files. Following intersection of the above two methods, 54 candidate autophagy‑associated kinases were obtained. Enrichment analysis indicated that these candidate autophagy‑associated kinases were mainly enriched in pathways such as the calcium, Wnt, HIF‑1 and mTOR signaling pathways. Among the 54 kinases, 24 were identified through text mining to have specific kinase inhibitors that regulate the corresponding functions; a total of 56 kinase inhibitors were found to be involved in the regulation of these 24 kinases. In total, nine of these 56 kinase inhibitors identified had been widely reported in autophagy regulation studies, 23 kinase inhibitors had been seldom reported and 24 had never been reported. Therefore, introducing these kinases into autophagy regulation analysis in subsequent studies may produce important results.

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