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Article

Identification of anesthetic‑induced expression changes using DNA microarray

  • Authors:
    • Zaiqi Yang
    • Mengyuan Zhang
    • Gongming Wang
    • Pihong Wei
    • Shenqiang Gao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Anesthesiology, Taian Central Hospital, Taian, Shandong 271000, P.R. China
  • Pages: 589-596
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    Published online on: October 16, 2014
       https://doi.org/10.3892/mmr.2014.2669
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Abstract

The present study aimed to identify changes in atrial gene expression induced by sevoflurane and propofol using DNA microarray. The expression profiles of GSE4386 in atrial samples, obtained from patients who had received either the anesthetic gas sevoflurane or the intravenous anesthetic propofol prior to and following off‑pump coronary artery bypass graft (CABG) surgery, were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) in the sevoflurane and the propofol groups were then identified and compared. Subsequently, a functional enrichment analysis was performed for the DEGs. The interactive functional modules for common, sevoflurane‑specific and propofol‑specific DEGs were then constructed for analysis of the biological processes. The percentages of common DEGs were 31.3 (275/879) and 94.8% (275/290) in the sevoflurane group and propofol groups, respectively. The functional categories for the common, sevoflurane‑specific and propofol‑specific DEGs were similar. Overall, two, one, and one functional modules were identified for the common DEGs, propofol specific DEGs and sevoflurane specific DEGs, respectively. DEGs in the modules were involved in cellular processes, including the ʻregulation of transcriptionʼ and ʻregulation of cellular processʼ, which were similar to the functional annotations for the DEGs. Therefore, sevoflurane and propofol may synergistically reduce myocardial reperfusion injury in patients undergoing off‑pump CABG surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Z, Zhang M, Wang G, Wei P and Gao S: Identification of anesthetic‑induced expression changes using DNA microarray. Mol Med Rep 11: 589-596, 2015.
APA
Yang, Z., Zhang, M., Wang, G., Wei, P., & Gao, S. (2015). Identification of anesthetic‑induced expression changes using DNA microarray. Molecular Medicine Reports, 11, 589-596. https://doi.org/10.3892/mmr.2014.2669
MLA
Yang, Z., Zhang, M., Wang, G., Wei, P., Gao, S."Identification of anesthetic‑induced expression changes using DNA microarray". Molecular Medicine Reports 11.1 (2015): 589-596.
Chicago
Yang, Z., Zhang, M., Wang, G., Wei, P., Gao, S."Identification of anesthetic‑induced expression changes using DNA microarray". Molecular Medicine Reports 11, no. 1 (2015): 589-596. https://doi.org/10.3892/mmr.2014.2669
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Z, Zhang M, Wang G, Wei P and Gao S: Identification of anesthetic‑induced expression changes using DNA microarray. Mol Med Rep 11: 589-596, 2015.
APA
Yang, Z., Zhang, M., Wang, G., Wei, P., & Gao, S. (2015). Identification of anesthetic‑induced expression changes using DNA microarray. Molecular Medicine Reports, 11, 589-596. https://doi.org/10.3892/mmr.2014.2669
MLA
Yang, Z., Zhang, M., Wang, G., Wei, P., Gao, S."Identification of anesthetic‑induced expression changes using DNA microarray". Molecular Medicine Reports 11.1 (2015): 589-596.
Chicago
Yang, Z., Zhang, M., Wang, G., Wei, P., Gao, S."Identification of anesthetic‑induced expression changes using DNA microarray". Molecular Medicine Reports 11, no. 1 (2015): 589-596. https://doi.org/10.3892/mmr.2014.2669
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