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Article

Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer

  • Authors:
    • Xing-Yu Feng
    • Xi-Zhi Wen
    • Xiao-Jing Tan
    • Jing-Hui Hou
    • Ya Ding
    • Ke‑Feng Wang
    • Jun Dong
    • Zhi-Wei Zhou
    • Ying-Bo Chen
    • Xiao-Shi Zhang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China, Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China
  • Pages: 658-664
    |
    Published online on: October 20, 2014
       https://doi.org/10.3892/mmr.2014.2699
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Abstract

It has been confirmed that B and T lymphocyte attenuator (BTLA; also known as CD272) is a novel co-­inhibitory molecule that exhibits a critical role in restraining cell-­mediated antitumor immunity. The present study aimed to investigate the expression and prognostic significance of BTLA in gastric adenocarcinoma. Immunohistochemical (IHC) staining was performed to investigate BTLA expression in gastric cancer tissues and normal mucosal tissues. In total, 123 pathologically confirmed specimens were obtained from stage IIIa gastric cancers. A correlation test, Kaplan-Meier curves, and a Cox proportional hazards regression model were used to analyze the data. No BTLA staining in the normal tissues was found, while BTLA-stained gastric carcinoma cells were detected in 75.6% (93/123) of the gastric cancer specimens. High expression levels of BTLA were detected in 31.7% (39/123) of the specimens, while low expression levels were detected in 68.3% (84/123) of the specimens. High BTLA expression levels were associated with shorter survival time, as confirmed by univariate and multivariate analyses. These findings provide a basis for the concept that high BTLA expression levels in gastric cancer, identified by IHC, are an independent biomarker for the poor prognosis of patients with gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Feng X, Wen X, Tan X, Hou J, Ding Y, Wang KF, Dong J, Zhou Z, Chen Y, Zhang X, Zhang X, et al: Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer. Mol Med Rep 11: 658-664, 2015.
APA
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K. ... Zhang, X. (2015). Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer. Molecular Medicine Reports, 11, 658-664. https://doi.org/10.3892/mmr.2014.2699
MLA
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K., Dong, J., Zhou, Z., Chen, Y., Zhang, X."Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer". Molecular Medicine Reports 11.1 (2015): 658-664.
Chicago
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K., Dong, J., Zhou, Z., Chen, Y., Zhang, X."Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer". Molecular Medicine Reports 11, no. 1 (2015): 658-664. https://doi.org/10.3892/mmr.2014.2699
Copy and paste a formatted citation
x
Spandidos Publications style
Feng X, Wen X, Tan X, Hou J, Ding Y, Wang KF, Dong J, Zhou Z, Chen Y, Zhang X, Zhang X, et al: Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer. Mol Med Rep 11: 658-664, 2015.
APA
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K. ... Zhang, X. (2015). Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer. Molecular Medicine Reports, 11, 658-664. https://doi.org/10.3892/mmr.2014.2699
MLA
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K., Dong, J., Zhou, Z., Chen, Y., Zhang, X."Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer". Molecular Medicine Reports 11.1 (2015): 658-664.
Chicago
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K., Dong, J., Zhou, Z., Chen, Y., Zhang, X."Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer". Molecular Medicine Reports 11, no. 1 (2015): 658-664. https://doi.org/10.3892/mmr.2014.2699
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