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Article

Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma

  • Authors:
    • Jinyan Zhao
    • Wei Lin
    • Zhiyun Cao
    • Qunchuan Zhuang
    • Liangpu Zheng
    • Jun Peng
    • Zhenfeng Hong
  • View Affiliations / Copyright

    Affiliations: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China
  • Pages: 357-361
    |
    Published online on: October 20, 2014
       https://doi.org/10.3892/mmr.2014.2702
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Abstract

Angiogenesis, which has a critical role in human tumor growth and development, is tightly regulated by the Notch signaling pathway. Total alkaloids are active components of the plant Rubus alceifolius Poir, which is used for the treatment of various types of cancer. A previous study by our group showed that the total alkaloids of Rubus alceifolius Poir (TARAP) induced hepatocellular carcinoma (HCC) cell apoptosis through the activation of the mitochondria‑dependent pathway in vitro and in vivo, as well as inhibited angiogenesis in a chick embryo chorioallantoic membrane model. In the present study, to further analyze the specific mechanisms underlying the antitumor activity of TARAP, a HCC xenograft mouse model was used to assess the effect of TARAP on angiogenesis in vivo. TARAP was found to suppress the expression of vascular endothelial growth factor (VEGF) A and VEGF receptor‑2 in tumor tissues, which resulted in the inhibition of tumor angiogenesis. In addition, TARAP treatment was observed to inhibit the expression of Notch1, delta‑like ligand 4 and jagged 1, which are key mediators of the Notch signaling pathway. The present study identified that the inhibition of tumor angiogenesis through the suppression of the Notch signaling pathway may be one of the mechanisms through which TARAP may be effective in the treatment of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Lin W, Cao Z, Zhuang Q, Zheng L, Peng J and Hong Z: Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma. Mol Med Rep 11: 357-361, 2015.
APA
Zhao, J., Lin, W., Cao, Z., Zhuang, Q., Zheng, L., Peng, J., & Hong, Z. (2015). Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma. Molecular Medicine Reports, 11, 357-361. https://doi.org/10.3892/mmr.2014.2702
MLA
Zhao, J., Lin, W., Cao, Z., Zhuang, Q., Zheng, L., Peng, J., Hong, Z."Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma". Molecular Medicine Reports 11.1 (2015): 357-361.
Chicago
Zhao, J., Lin, W., Cao, Z., Zhuang, Q., Zheng, L., Peng, J., Hong, Z."Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma". Molecular Medicine Reports 11, no. 1 (2015): 357-361. https://doi.org/10.3892/mmr.2014.2702
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Lin W, Cao Z, Zhuang Q, Zheng L, Peng J and Hong Z: Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma. Mol Med Rep 11: 357-361, 2015.
APA
Zhao, J., Lin, W., Cao, Z., Zhuang, Q., Zheng, L., Peng, J., & Hong, Z. (2015). Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma. Molecular Medicine Reports, 11, 357-361. https://doi.org/10.3892/mmr.2014.2702
MLA
Zhao, J., Lin, W., Cao, Z., Zhuang, Q., Zheng, L., Peng, J., Hong, Z."Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma". Molecular Medicine Reports 11.1 (2015): 357-361.
Chicago
Zhao, J., Lin, W., Cao, Z., Zhuang, Q., Zheng, L., Peng, J., Hong, Z."Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma". Molecular Medicine Reports 11, no. 1 (2015): 357-361. https://doi.org/10.3892/mmr.2014.2702
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