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Article

Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats

  • Authors:
    • Qi Zhang
    • Yingying Tan
    • Nan Zhang
    • Fanrong Yao
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Basic Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China, Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
  • Pages: 603-610
    |
    Published online on: October 20, 2014
       https://doi.org/10.3892/mmr.2014.2708
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Abstract

The pathophysiology of non‑alcoholic fatty liver disease remains to be elucidated, and the currently available treatments are not entirely effective. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspi­datum, has previously been demonstrated to possess hepatoprotective effects. The present study aimed to determine the effects of polydatin supplementation on hepatic fat accumulation and injury in rats fed a high‑fat diet. In addition, the mechanisms underlying the protective effects of polydatin were examined. Male Sprague Dawley rats were randomly divided into four groups and received one of four treatment regimes for 12 weeks: Control diet, control diet supplemented with polydatin, high‑fat diet, or high‑fat diet supplemented with polydatin. Polydatin was supplemented in the drinking water at a concentration of 0.3% (wt/vol). The results of the present study showed that long‑term high‑fat feeding resulted in fatty liver in rats, which was manifested by excessive hepatic neutral fat accumulation and elevated plasma alanine aminotrans­ferase and aspartate aminotransferase levels. Polydatin supplementation alleviated the hepatic pathological changes, and attenuated the insulin resistance, as shown by an improved homeostasis model assessment of basal insulin resistance values and a glucose tolerance test. Polydatin supplementation also corrected abnormal leptin and adiponectin levels. Specifically, polydatin supplementation enhanced insulin sensitivity in the liver, as shown by improved insulin receptor substrate 2 expression levels and Akt phosphorylation in the rat liver, following high‑fat diet feeding. The results of the present study suggest that polydatin protects rats against high‑fat feeding‑induced insulin resistance and hepatic steatosis. Polydatin may be an effective hepatoprotective agent and a potential candidate for the prevention of fatty liver disease and insulin resistance.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Tan Y, Zhang N and Yao F: Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats. Mol Med Rep 11: 603-610, 2015.
APA
Zhang, Q., Tan, Y., Zhang, N., & Yao, F. (2015). Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats. Molecular Medicine Reports, 11, 603-610. https://doi.org/10.3892/mmr.2014.2708
MLA
Zhang, Q., Tan, Y., Zhang, N., Yao, F."Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats". Molecular Medicine Reports 11.1 (2015): 603-610.
Chicago
Zhang, Q., Tan, Y., Zhang, N., Yao, F."Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats". Molecular Medicine Reports 11, no. 1 (2015): 603-610. https://doi.org/10.3892/mmr.2014.2708
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Tan Y, Zhang N and Yao F: Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats. Mol Med Rep 11: 603-610, 2015.
APA
Zhang, Q., Tan, Y., Zhang, N., & Yao, F. (2015). Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats. Molecular Medicine Reports, 11, 603-610. https://doi.org/10.3892/mmr.2014.2708
MLA
Zhang, Q., Tan, Y., Zhang, N., Yao, F."Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats". Molecular Medicine Reports 11.1 (2015): 603-610.
Chicago
Zhang, Q., Tan, Y., Zhang, N., Yao, F."Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats". Molecular Medicine Reports 11, no. 1 (2015): 603-610. https://doi.org/10.3892/mmr.2014.2708
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