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Article

Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury

  • Authors:
    • Jae‑Wook Yang
    • Soung‑Min Lee
    • Kyeong‑Hee Oh
    • Sae‑Gwang  Park
    • Ii‑Whan Choi
    • Su‑Kil Seo
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Busan Paik Hospital, Inje University, Busan 614‑735, Republic of Korea, Ocular Neovascular Research Center, College of Medicine, Inje University, Busan 614‑735, Republic of Korea
  • Pages: 461-467
    |
    Published online on: October 21, 2014
       https://doi.org/10.3892/mmr.2014.2722
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Abstract

Numerous treatments have been used in the management of corneal chemical burns; however, no optimal treatment for corneal chemical burns currently exists. The present study investigated the effects of topical chondrocyte‑derived extracellular matrix (CD‑ECM) treatment on corneal wound healing, using an alkali burn mouse model. Topical treatment with CD‑ECM was shown to reduce corneal opacity following an alkali burn. A histological examination observed the presence of regenerated epithelial cells and a small number of inflammatory cells in the corneas of CD‑ECM‑treated mice. The majority of the inflammatory cells present in the corneas of the phosphate‑buffered saline (PBS)‑treated mice were neutrophils that expressed matrix metalloproteinase (MMP)‑9. The amount of neutrophils was significantly reduced in the corneas of the CD‑ECM‑treated mice. Furthermore, the expression levels of interleukin (IL)‑8 were significantly reduced in the CD‑ECM treatment group, but not in the mice that received the PBS treatment. The results of the present study indicate that CD‑ECM treatment may accelerate wound healing in a model of alkali burn‑induced corneal injury. The therapeutic mechanism may be associated with accelerated reepithelialization and reduced recruitment of MMP‑9‑expressing neutrophils, through inhibiting the production of IL‑8.
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Copy and paste a formatted citation
Spandidos Publications style
Yang JW, Lee SM, Oh KH, Park SG, Choi IW and Seo SK: Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury. Mol Med Rep 11: 461-467, 2015.
APA
Yang, J., Lee, S., Oh, K., Park, S., Choi, I., & Seo, S. (2015). Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury. Molecular Medicine Reports, 11, 461-467. https://doi.org/10.3892/mmr.2014.2722
MLA
Yang, J., Lee, S., Oh, K., Park, S., Choi, I., Seo, S."Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury". Molecular Medicine Reports 11.1 (2015): 461-467.
Chicago
Yang, J., Lee, S., Oh, K., Park, S., Choi, I., Seo, S."Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury". Molecular Medicine Reports 11, no. 1 (2015): 461-467. https://doi.org/10.3892/mmr.2014.2722
Copy and paste a formatted citation
x
Spandidos Publications style
Yang JW, Lee SM, Oh KH, Park SG, Choi IW and Seo SK: Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury. Mol Med Rep 11: 461-467, 2015.
APA
Yang, J., Lee, S., Oh, K., Park, S., Choi, I., & Seo, S. (2015). Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury. Molecular Medicine Reports, 11, 461-467. https://doi.org/10.3892/mmr.2014.2722
MLA
Yang, J., Lee, S., Oh, K., Park, S., Choi, I., Seo, S."Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury". Molecular Medicine Reports 11.1 (2015): 461-467.
Chicago
Yang, J., Lee, S., Oh, K., Park, S., Choi, I., Seo, S."Effects of topical chondrocyte‑derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury". Molecular Medicine Reports 11, no. 1 (2015): 461-467. https://doi.org/10.3892/mmr.2014.2722
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