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Article

Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells

  • Authors:
    • Wei Shang
    • Xuejing Yu
    • Honglian Wang
    • Tielin Chen
    • Ying Fang
    • Xianggui  Yang
    • Puhui Zhou
    • Fang Nie
    • Qin Zhou
    • Jianzhong Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China, Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, The Division of Molecular Nephrology, The College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 503-508
    |
    Published online on: October 21, 2014
       https://doi.org/10.3892/mmr.2014.2731
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Abstract

Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator. The present study aimed to investigate the effect of FGF21 on cholesterol efflux and the expression of ATP binding cassette (ABC) A1 and G1 in human THP‑1 macrophage‑derived foam cells. Furthermore, the present study aimed to investigate the role of the liver X receptor (LXR) α in this process. A model of oxidized low‑density lipoprotein‑induced foam cells from human THP‑1 cells was established. The effect of FGF21 on cholesterol efflux was analyzed using a liquid scintillation counter. The expression of ABCA1 and ABCG1 was determined using quantitative polymerase chain reaction and western blot analyses. FGF21 was found to enhance apolipoprotein A1‑ and high‑density lipoprotein‑mediated cholesterol efflux. FGF21 was also observed to increase the mRNA and protein expression of ABCA1 and ABCG1. Furthermore, LXRα‑short interfering RNA attenuated the stimulatory effects induced by FGF21. These findings suggest that FGF21 may have a protective effect against atherosclerosis by enhancing cholesterol efflux through the induction of LXRα‑dependent ABCA1 and ABCG1 expression.
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Copy and paste a formatted citation
Spandidos Publications style
Shang W, Yu X, Wang H, Chen T, Fang Y, Yang X, Zhou P, Nie F, Zhou Q, Zhou J, Zhou J, et al: Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells. Mol Med Rep 11: 503-508, 2015.
APA
Shang, W., Yu, X., Wang, H., Chen, T., Fang, Y., Yang, X. ... Zhou, J. (2015). Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells. Molecular Medicine Reports, 11, 503-508. https://doi.org/10.3892/mmr.2014.2731
MLA
Shang, W., Yu, X., Wang, H., Chen, T., Fang, Y., Yang, X., Zhou, P., Nie, F., Zhou, Q., Zhou, J."Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells". Molecular Medicine Reports 11.1 (2015): 503-508.
Chicago
Shang, W., Yu, X., Wang, H., Chen, T., Fang, Y., Yang, X., Zhou, P., Nie, F., Zhou, Q., Zhou, J."Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells". Molecular Medicine Reports 11, no. 1 (2015): 503-508. https://doi.org/10.3892/mmr.2014.2731
Copy and paste a formatted citation
x
Spandidos Publications style
Shang W, Yu X, Wang H, Chen T, Fang Y, Yang X, Zhou P, Nie F, Zhou Q, Zhou J, Zhou J, et al: Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells. Mol Med Rep 11: 503-508, 2015.
APA
Shang, W., Yu, X., Wang, H., Chen, T., Fang, Y., Yang, X. ... Zhou, J. (2015). Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells. Molecular Medicine Reports, 11, 503-508. https://doi.org/10.3892/mmr.2014.2731
MLA
Shang, W., Yu, X., Wang, H., Chen, T., Fang, Y., Yang, X., Zhou, P., Nie, F., Zhou, Q., Zhou, J."Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells". Molecular Medicine Reports 11.1 (2015): 503-508.
Chicago
Shang, W., Yu, X., Wang, H., Chen, T., Fang, Y., Yang, X., Zhou, P., Nie, F., Zhou, Q., Zhou, J."Fibroblast growth factor 21 enhances cholesterol efflux in THP‑1 macrophage‑derived foam cells". Molecular Medicine Reports 11, no. 1 (2015): 503-508. https://doi.org/10.3892/mmr.2014.2731
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