Silencing insulin‑like growth factor‑1 receptor expression inhibits gastric cancer cell proliferation and invasion

  • Authors:
    • Jie Ge
    • Zihua Chen
    • Jin Huang
    • Weijie Yuan
    • Zhenghao Den
    • Zhikang Chen
  • View Affiliations

  • Published online on: October 22, 2014     https://doi.org/10.3892/mmr.2014.2746
  • Pages: 633-638
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Abstract

The oncoprotein insulin‑like growth factor‑1 receptor (IGF‑1R) has previously been shown to promote tumorigenesis. Overexpression of IGF‑1R is considered to be a critical prerequisite for malignant transformation in numerous human cancers. Therefore, targeting IGF‑1R for cancer therapy has gained a lot of interest. In the present study, an RNA interference (RNAi)‑mediated IGF‑1R gene silencing approach was conducted in BGC823 gastric cancer cells. The tumorigenic and malignant properties of the cells were assessed, in response to reduced IGF‑1R expression. Notably, IGF‑1R depletion not only inhibited gastric cancer cell growth, resulted in G1 cell cycle arrest and consequently led to apoptosis, but also suppressed cancer cell motility and invasion. The findings of the present study are the first, to the best of our knowledge, to suggest that RNAi‑based IGF‑1R silencing may be a potential and promising therapeutic strategy for gastric cancer treatment.
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January-2015
Volume 11 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ge J, Chen Z, Huang J, Yuan W, Den Z and Chen Z: Silencing insulin‑like growth factor‑1 receptor expression inhibits gastric cancer cell proliferation and invasion. Mol Med Rep 11: 633-638, 2015.
APA
Ge, J., Chen, Z., Huang, J., Yuan, W., Den, Z., & Chen, Z. (2015). Silencing insulin‑like growth factor‑1 receptor expression inhibits gastric cancer cell proliferation and invasion. Molecular Medicine Reports, 11, 633-638. https://doi.org/10.3892/mmr.2014.2746
MLA
Ge, J., Chen, Z., Huang, J., Yuan, W., Den, Z., Chen, Z."Silencing insulin‑like growth factor‑1 receptor expression inhibits gastric cancer cell proliferation and invasion". Molecular Medicine Reports 11.1 (2015): 633-638.
Chicago
Ge, J., Chen, Z., Huang, J., Yuan, W., Den, Z., Chen, Z."Silencing insulin‑like growth factor‑1 receptor expression inhibits gastric cancer cell proliferation and invasion". Molecular Medicine Reports 11, no. 1 (2015): 633-638. https://doi.org/10.3892/mmr.2014.2746