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Article

Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice

  • Authors:
    • Xiao‑Dan Han
    • Min Li
    • Xiao‑Guang Zhang
    • Zhang‑Gang Xue
    • Jing Cang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 226-230
    |
    Published online on: October 23, 2014
       https://doi.org/10.3892/mmr.2014.2751
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Abstract

Sevoflurane is an inhaled anesthetic that is widely used in clinical practice, particularly for pediatric anesthesia. Previous studies have suggested that sevoflurane may induce neurotoxicity in the brains of neonatal mice. In the present study, the possible mechanism of neurodegeneration induced by sevoflurane in the developing brain, and the possibility that memantine treatment is able to reverse this phenomenon, were investigated. On postnatal day 7 (P7) C57BL/6 mice were continuously exposed to 1.5% sevoflurane for 2 h following pre‑injection of saline or memantine. Methyl‑CpG island binding protein 2 (MeCP2), cAMP response element‑binding protein (CREB) and brain‑derived neurotrophic factor (BDNF) expression in the hippocampus was measured by western blotting. Exposure to 1.5% sevoflurane resulted in increased MeCP2 phosphorylation in the hippocampus, which was reversed by memantine injection. However, neither CREB phosphorylation nor BDNF expression were significantly altered by sevoflurane treatment. The current study indicated that sevoflurane causes neurotoxicity in the developing brain, and that this may be attributed to increased MeCP2 phosphorylation in the hippocampus. It was also demonstrated that this neurotoxicity can be prevented by the N‑methyl‑D‑aspartate glutamate receptor inhibitor memantine.
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Copy and paste a formatted citation
Spandidos Publications style
Han XD, Li M, Zhang XG, Xue ZG and Cang J: Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice. Mol Med Rep 11: 226-230, 2015.
APA
Han, X., Li, M., Zhang, X., Xue, Z., & Cang, J. (2015). Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice. Molecular Medicine Reports, 11, 226-230. https://doi.org/10.3892/mmr.2014.2751
MLA
Han, X., Li, M., Zhang, X., Xue, Z., Cang, J."Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice". Molecular Medicine Reports 11.1 (2015): 226-230.
Chicago
Han, X., Li, M., Zhang, X., Xue, Z., Cang, J."Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice". Molecular Medicine Reports 11, no. 1 (2015): 226-230. https://doi.org/10.3892/mmr.2014.2751
Copy and paste a formatted citation
x
Spandidos Publications style
Han XD, Li M, Zhang XG, Xue ZG and Cang J: Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice. Mol Med Rep 11: 226-230, 2015.
APA
Han, X., Li, M., Zhang, X., Xue, Z., & Cang, J. (2015). Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice. Molecular Medicine Reports, 11, 226-230. https://doi.org/10.3892/mmr.2014.2751
MLA
Han, X., Li, M., Zhang, X., Xue, Z., Cang, J."Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice". Molecular Medicine Reports 11.1 (2015): 226-230.
Chicago
Han, X., Li, M., Zhang, X., Xue, Z., Cang, J."Single sevoflurane exposure increases methyl‑CpG island binding protein 2 phosphorylation in the hippocampus of developing mice". Molecular Medicine Reports 11, no. 1 (2015): 226-230. https://doi.org/10.3892/mmr.2014.2751
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