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Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway

  • Authors:
    • Qiuyan Wang
    • Xiaohui Sun
    • Xiaobin Li
    • Xiang Dong
    • Peng Li
    • Li Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Emergency Department, First Affiliated Hospital of Dalian Medical University, Dalian 116011, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 151-158
    |
    Published online on: October 23, 2014
       https://doi.org/10.3892/mmr.2014.2762
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Abstract

Obstructive sleep apnea can induce chronic intermittent hypoxia (CIH) during sleep and is associated with obesity and diabetes. Resveratrol (RSV), a polyphenolic phytoalexin, can regulate glucose metabolism, thereby reducing insulin resistance. The present study aimed to assess whether RSV attenuates CIH‑induced insulin resistance in rats and the underlying mechanisms. A total of 40 rats were randomly assigned into five groups: i) Control; ii) subjected to CIH only; iii) subjected to CIH and treated with 3 mg/kg/day of RSV; iv) subjected to CIH and treated with 30 mg/kg/day of RSV; v) subjected to CIH and treated with 60 mg/kg/day of RSV. All animals were sacrificed following 28 days of treatment. Subsequently, the blood and livers were harvested and blood insulin and glucose levels were measured. Levels of sirtuin (Sirt) 1, insulin receptor (InsR) and glucose transporter 2 (Glut2) in the liver were measured. RSV treatment was demonstrated to suppress weight gain and improve hepatic morphology. RSV treatment also significantly reduced the homeostasis model assessment estimate of insulin resistance of the rats exposed to CIH. This effect occurred in a dose‑dependent manner. RSV significantly upregulated liver Sirt1 levels and inhibited InsR and Glut2 expression in the liver. Additionally, RSV activated the phosphorylation of phosphatidylinositol‑4,5‑bisphosphate 3‑kinase (PI3K) and AKT. The present study demonstrates that RSV prevents CIH‑induced insulin resistance in rats. Upregulation of Sirt1 and activation of PI3K/AKT signaling may be involved in this process.
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1 

Punjabi NM: The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 5:136–143. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Casale M, et al: Obstructive sleep apnea syndrome: from phenotype to genetic basis. Curr Genomics. 10:119–126. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Young T, Palta M, Dempsey J, Skatrud J, Weber S and Badr S: The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 328:1230–1235. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Tasali E and Ip MS: Obstructive sleep apnea and metabolic syndrome: Alterations in glucose metabolism and inflammation. Proc Am Thorac Soc. 5:207–217. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Coughlin SR, Mawdsley L, Mugarza JA, Calverley PM and Wilding JP: Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J. 25:735–741. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Ip MS, Lam B, Ng MM, Lam WK, Tsang KW and Lam KS: Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med. 165:670–676. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R and Resnick HE; Sleep Heart Health Study I. Sleep-disordered breathing, glucose intolerance, and insulin resistance: The sleep heart health study. Am J Epidemiol. 160:521–530. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Goodson BL, Wung SF and Archbold KH: Obstructive sleep apnea hypopnea syndrome and metabolic syndrome: a synergistic cardiovascular risk factor. J Am Acad Nurse Pract. 24:695–703. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Gao ZH, Yuan RY, Chen KY and Li GP: Obstructive sleep apnea and the metabolic syndrome. Sleep Breath. 16:937–938. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Byberg S, Hansen AL, Christensen DL, Vistisen D, Aadahl M, Linneberg A and Witte DR: Sleep duration and sleep quality are associated differently with alterations of glucose homeostasis. Diabet Med. 29:e354–e360. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Van Cauter E: Sleep disturbances and insulin resistance. Diabet Med. 28:1455–1462. 2011.PubMed/NCBI

12 

Spiegel K, Knutson K, Leproult R, Tasali E and Van Cauter E: Sleep loss: A novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol. 99:2008–2019. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Finkel T, Deng CX and Mostoslavsky R: Recent progress in the biology and physiology of sirtuins. Nature. 460:587–591. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Chakraborty C and Doss CG: Sirtuins family-recent development as a drug target for aging, metabolism and age related diseases. Curr Drug Targets. 14:666–675. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Pucci B, Villanova L, Sansone L, Pellegrini L, Tafani M, Carpi A, Fini M and Russo MA: Sirtuins: The molecular basis of beneficial effects of physical activity. Intern Emerg Med. 8(Suppl 1): S23–S25. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Bagul PK and Banerjee SK: Insulin resistance, oxidative stress and cardiovascular complications: Role of sirtuins. Curr Pharm Des. 19:5663–5677. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Chen YR, Lai YL, Lin SD, Li XT, Fu YC and Xu WC: Sirt1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats. Mol Biol Rep. 40:3373–3380. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Jung TW, Lee KT, Lee MW and Ka KH: Sirt1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in hepg2 cells via induction of oxygen-regulated protein 150. Biochem Biophys Res Commun. 422:229–232. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O and Deng CX: Hepatic sirt1 deficiency in mice impairs mtorc2/akt signaling and results in hyperglycemia, oxidative damage and insulin resistance. J Clin Invest. 121:4477–4490. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R and Sinclair DA: Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444:337–342. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P and Auwerx J: Resveratrol improves mitochondrial function and protects against metabolic disease by activating sirt1 and pgc-1alpha. Cell. 127:1109–1122. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Tennen RI, Michishita-Kioi E and Chua KF: Finding a target for resveratrol. Cell. 148:387–389. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Franzel B, Tomaschewski J, Aladini F, Becker C, Wolters D and Steegborn C: A molecular mechanism for direct sirtuin activation by resveratrol. PloS One. 7:e497612012. View Article : Google Scholar : PubMed/NCBI

24 

Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O’Doherty RM, Polotsky VY and O’Donnell CP: Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med. 175:851–857. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Polotsky VY, Rubin AE, Balbir A, Dean T, Smith PL, Schwartz AR and O’Donnell CP: Intermittent hypoxia causes rem sleep deficits and decreases eeg delta power in nrem sleep in the c57bl/6j mouse. Sleep Med. 7:7–16. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Choi K and Kim YB: Molecular mechanism of insulin resistance in obesity and type 2 diabetes. Korean J Intern Med. 25:119–129. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Babacanoglu C, Yildirim N, Sadi G, Pektas MB and Akar F: Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats. Food Chem Toxicol. 60:160–167. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Cheng AS, Cheng YH, Chiou CH and Chang TL: Resveratrol upregulates nrf2 expression to attenuate methylglyoxal-induced insulin resistance in hep g2 cells. J Agric Food Chem. 60:9180–9187. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S and Banerjee SK: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacol Res. 66:260–268. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Chen S, Li J, Zhang Z, Li W, Sun Y, Zhang Q, Feng X and Zhu W: Effects of resveratrol on the amelioration of insulin resistance in kkay mice. Can J Physiol Pharmacol. 90:237–242. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Zheng J, Chen LL, Zhang HH, Hu X, Kong W and Hu D: Resveratrol improves insulin resistance of catch-up growth by increasing mitochondrial complexes and antioxidant function in skeletal muscle. Metabolism. 61:954–965. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Chen LL, Zhang HH, Zheng J, Hu X, Kong W, Hu D, Wang SX and Zhang P: Resveratrol attenuates high-fat diet-induced insulin resistance by influencing skeletal muscle lipid transport and subsarcolemmal mitochondrial beta-oxidation. Metabolism. 60:1598–1609. 2011. View Article : Google Scholar

33 

Labbé A, Garand C, Cogger VC, Paquet ER, Desbiens M, Le Couteur DG and Lebel M: Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation and life span in a mouse model for Werner syndrome. J Gerontol A Biol Sci Med Sci. 66:264–278. 2011.PubMed/NCBI

34 

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B and Sinclair DA: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425:191–196. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Yun JM, Chien A, Jialal I and Devaraj S: Resveratrol up-regulates sirt1 and inhibits cellular oxidative stress in the diabetic milieu: Mechanistic insights. J Nutr Biochem. 23:699–705. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Liang F, Kume S and Koya D: Sirt1 and insulin resistance. Nat Rev Endocrinol. 5:367–373. 2009. View Article : Google Scholar

37 

Zabolotny JM and Kim YB: Silencing insulin resistance through sirt1. Cell Metab. 6:247–249. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Farese RV, Sajan MP and Standaert ML: Insulin-sensitive protein kinases (atypical protein kinase c and protein kinase b/akt): Actions and defects in obesity and type II diabetes. Exp Biol Med (Maywood). 230:593–605. 2005.PubMed/NCBI

39 

Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J and Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 s6 kinase, DNA synthesis and glucose transporter translocation. Mol Cell Biol. 14:4902–4911. 1994.

40 

Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR and Kahn BB: Normal insulin-dependent activation of akt/protein kinase b, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest. 104:733–741. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Bjornholm M, Kawano Y, Lehtihet M and Zierath JR: Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from niddm subjects after in vivo insulin stimulation. Diabetes. 46:524–527. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Frojdo S, Durand C, Molin L, Carey AL, El-Osta A, Kingwell BA, Febbraio MA, Solari F, Vidal H and Pirola L: Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by sirt1. Mol Cell Endocrinol. 335:166–276. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Sun X, Li X, Dong X, Li P and Zhao L: Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway. Mol Med Rep 11: 151-158, 2015.
APA
Wang, Q., Sun, X., Li, X., Dong, X., Li, P., & Zhao, L. (2015). Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway. Molecular Medicine Reports, 11, 151-158. https://doi.org/10.3892/mmr.2014.2762
MLA
Wang, Q., Sun, X., Li, X., Dong, X., Li, P., Zhao, L."Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway". Molecular Medicine Reports 11.1 (2015): 151-158.
Chicago
Wang, Q., Sun, X., Li, X., Dong, X., Li, P., Zhao, L."Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway". Molecular Medicine Reports 11, no. 1 (2015): 151-158. https://doi.org/10.3892/mmr.2014.2762
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Sun X, Li X, Dong X, Li P and Zhao L: Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway. Mol Med Rep 11: 151-158, 2015.
APA
Wang, Q., Sun, X., Li, X., Dong, X., Li, P., & Zhao, L. (2015). Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway. Molecular Medicine Reports, 11, 151-158. https://doi.org/10.3892/mmr.2014.2762
MLA
Wang, Q., Sun, X., Li, X., Dong, X., Li, P., Zhao, L."Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway". Molecular Medicine Reports 11.1 (2015): 151-158.
Chicago
Wang, Q., Sun, X., Li, X., Dong, X., Li, P., Zhao, L."Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/AKT pathway". Molecular Medicine Reports 11, no. 1 (2015): 151-158. https://doi.org/10.3892/mmr.2014.2762
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