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Article Open Access

Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells

  • Authors:
    • Huading Lu
    • Liyi Lian
    • Dehai Shi
    • Huiqing Zhao
    • Yuhu Dai
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 143-150
    |
    Published online on: October 24, 2014
       https://doi.org/10.3892/mmr.2014.2769
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Abstract

The ability of mesenchymal stem cells (MSCs) to differentiate into osteogenic lineages requires management for their future use in treating bone destruction and osteoporosis. Hepcidin is closely associated with bone metabolism, however, it remains to be elucidated whether hepcidin affects osteogenic differentiation in MSCs. The present study demonstrated that hepcidin enhanced osteoblastic differentiation and mineralization, which was manifested by an upregulation in the differentiation markers alkaline phosphatase and osteogenic genes. Furthermore, the expression levels of bone morphogenetic proteins and small mothers against decapentaplegic homologs were concomitantly increased following hepcidin treatment. In addition, the p38 mitogen‑activated protein kinase may be an upstream kinase for osteoblastic differentiation. Thus, hepcidin may be important in the osteogenic differentiation of MSCs and may be considered as a target in the development of therapies for pathological bone loss.
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Copy and paste a formatted citation
Spandidos Publications style
Lu H, Lian L, Shi D, Zhao H and Dai Y: Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells. Mol Med Rep 11: 143-150, 2015.
APA
Lu, H., Lian, L., Shi, D., Zhao, H., & Dai, Y. (2015). Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells. Molecular Medicine Reports, 11, 143-150. https://doi.org/10.3892/mmr.2014.2769
MLA
Lu, H., Lian, L., Shi, D., Zhao, H., Dai, Y."Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells". Molecular Medicine Reports 11.1 (2015): 143-150.
Chicago
Lu, H., Lian, L., Shi, D., Zhao, H., Dai, Y."Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells". Molecular Medicine Reports 11, no. 1 (2015): 143-150. https://doi.org/10.3892/mmr.2014.2769
Copy and paste a formatted citation
x
Spandidos Publications style
Lu H, Lian L, Shi D, Zhao H and Dai Y: Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells. Mol Med Rep 11: 143-150, 2015.
APA
Lu, H., Lian, L., Shi, D., Zhao, H., & Dai, Y. (2015). Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells. Molecular Medicine Reports, 11, 143-150. https://doi.org/10.3892/mmr.2014.2769
MLA
Lu, H., Lian, L., Shi, D., Zhao, H., Dai, Y."Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells". Molecular Medicine Reports 11.1 (2015): 143-150.
Chicago
Lu, H., Lian, L., Shi, D., Zhao, H., Dai, Y."Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen‑activated protein kinase/P38 signaling pathways in mesenchymal stem cells". Molecular Medicine Reports 11, no. 1 (2015): 143-150. https://doi.org/10.3892/mmr.2014.2769
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