Role of cysteine‑rich angiogenic inducer 61 in fibroblast‑like synovial cell proliferation and invasion in rheumatoid arthritis Corrigendum in /10.3892/mmr.2022.12901

Jie,Li‑Gang; Huang,Run‑Yue; Sun,Wei‑Feng; Wei,Song; Chu,Yong‑Liang; Huang,Qing‑Chun; Du,Hong‑Yan

doi:10.3892/mmr.2014.2770

February-2015 Volume 11 Issue 2

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February-2015 Volume 11 Issue 2

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Article Open Access

Role of cysteine‑rich angiogenic inducer 61 in fibroblast‑like synovial cell proliferation and invasion in rheumatoid arthritis

Corrigendum in: /10.3892/mmr.2022.12901

Authors:
- Li‑Gang Jie
- Run‑Yue Huang
- Wei‑Feng Sun
- Song Wei
- Yong‑Liang Chu
- Qing‑Chun Huang
- Hong‑Yan Du
View Affiliations / Copyright

Affiliations: Department of Chinese Medicine, Guangzhou General Hospital of Guangzhou Command of PLA, Guangzhou, Guangdong 510010, P.R. China, Department of Rheumatology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China, School of Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China

Copyright: © Jie et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
Pages: 917-923
|
Published online on: October 27, 2014

https://doi.org/10.3892/mmr.2014.2770
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Abstract

Cysteine‑rich angiogenic inducer 61 (Cyr61) is a novel molecule that has been shown to be increased in the synovial tissues of patients with rheumatoid arthritis (RA). The present study was conducted in order to investigate the role of Cyr61 in the pathogenesis of RA. A human genome‑wide gene assay was used to screen gene expression in synovial tissues obtained from four patients with RA and three patients with osteoarthritis (OA). To examine the role of Cyr61 in the phenotype of RA‑fibroblast‑like synovial (FLS) cells, Cyr61 expression in RA‑FLS cells was knocked down using small interfering RNA (siRNA). Normal FLS cells transduced with lentiviral vectors encoding Cyr61 cDNA were used to further explore the effects of this molecule on FLS cell apoptosis, proliferation and invasion. The study found that the Cyr61 gene was highly expressed in the synovial cells from patients with RA compared with those from patients with OA. Downregulation of Cyr61 by siRNA led to impaired cell proliferation and invasion. Furthermore, it decreased the levels of matrix metalloproteinase (MMP)‑3 and MMP‑13, and induced apoptosis in RA‑FLS cells. Conversely, overexpression of Cyr61 in normal FLS cells led to opposite effects. In conclusion, these results indicate that Cyr61 is capable of promoting RA‑FLS cell proliferation and invasion via the suppression of apoptosis and the regulation of MMP expression. Therefore, Cyr61 may be a good target molecule for the treatment and prevention of RA.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of cysteine‑rich angiogenic inducer 61 in fibroblast‑like synovial cell proliferation and invasion in rheumatoid arthritis

Corrigendum in: /10.3892/mmr.2022.12901

This article is mentioned in:

Abstract

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