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Article

Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma

  • Authors:
    • Huo‑Chun Yi
    • Ya‑Li Liu
    • Pan You
    • Jin‑Shui Pan
    • Jian‑Yan Zhou
    • Zhen‑Jin Liu
    • Zhong-Ying Zhang
  • View Affiliations / Copyright

    Affiliations: Center of Clinical Laboratory, Zhongshan Hospital, Medical College of Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Thoracic Surgery, Zhongshan Hospital, Medical College of Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Gastroenterology, Zhongshan Hospital, Medical College of Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Hepatobiliary Surgery, Zhongshan Hospital, Medical College of Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Pathology, Zhongshan Hospital, Medical College of Xiamen University, Xiamen, Fujian 361004, P.R. China
  • Pages: 1318-1323
    |
    Published online on: October 27, 2014
       https://doi.org/10.3892/mmr.2014.2781
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Abstract

The oncogene DEK was originally identified as one of the parts of the DEK‑CAN fusion gene, arising from the translocation (6;9) in a subtype of acute myeloid leukemia. Since then, DEK has been shown to promote tumorigenesis in a variety of cancer cell types through its roles in inhibiting cell differentiation, senescence and apoptosis. Certain studies have established that DEK is dysregulated in several types of cancer, including hepatocellular carcinoma (HCC). However, its clinical significance in human HCC remains unknown. In this study, the expression of DEK mRNA and protein was examined in 55 surgical HCC specimens and matched non‑tumorous tissues. In addition, the correlation between DEK expression and clinicopathological characteristics and prognosis was analyzed. mRNA and protein levels of DEK were found to be significantly overexpressed in the majority of HCC tumors when compared with matched normal hepatic tissues (P<0.05). In addition, the expression pattern of DEK was closely correlated with differentiation status, portal venous invasion and tumor size (P<0.05). Kaplan‑Meier curves demonstrated that patients with higher DEK expression levels had significantly poorer survival than those with lower DEK expression levels (P=0.003). In addition, Cox regression analysis demonstrated that the level of DEK expression may be a valuable prognostic factor (P<0.05). These results suggested that DEK may play a significant role in hepatocyte differentiation and may serve as a useful prognostic marker and biomarker for the staging of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yi HC, Liu YL, You P, Pan JS, Zhou JY, Liu ZJ and Zhang Z: Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma. Mol Med Rep 11: 1318-1323, 2015.
APA
Yi, H., Liu, Y., You, P., Pan, J., Zhou, J., Liu, Z., & Zhang, Z. (2015). Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma. Molecular Medicine Reports, 11, 1318-1323. https://doi.org/10.3892/mmr.2014.2781
MLA
Yi, H., Liu, Y., You, P., Pan, J., Zhou, J., Liu, Z., Zhang, Z."Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma". Molecular Medicine Reports 11.2 (2015): 1318-1323.
Chicago
Yi, H., Liu, Y., You, P., Pan, J., Zhou, J., Liu, Z., Zhang, Z."Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma". Molecular Medicine Reports 11, no. 2 (2015): 1318-1323. https://doi.org/10.3892/mmr.2014.2781
Copy and paste a formatted citation
x
Spandidos Publications style
Yi HC, Liu YL, You P, Pan JS, Zhou JY, Liu ZJ and Zhang Z: Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma. Mol Med Rep 11: 1318-1323, 2015.
APA
Yi, H., Liu, Y., You, P., Pan, J., Zhou, J., Liu, Z., & Zhang, Z. (2015). Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma. Molecular Medicine Reports, 11, 1318-1323. https://doi.org/10.3892/mmr.2014.2781
MLA
Yi, H., Liu, Y., You, P., Pan, J., Zhou, J., Liu, Z., Zhang, Z."Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma". Molecular Medicine Reports 11.2 (2015): 1318-1323.
Chicago
Yi, H., Liu, Y., You, P., Pan, J., Zhou, J., Liu, Z., Zhang, Z."Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma". Molecular Medicine Reports 11, no. 2 (2015): 1318-1323. https://doi.org/10.3892/mmr.2014.2781
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