Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation

Yao,Wei‑Yan; Zhou,Yu‑Fen; Qian,Ai‑Hua; Zhang,Yong‑Ping; Qiao,Min‑Min; Zhai,Zu‑Kang; Yuan,Yao‑Zong; Yang,Song‑Lin

doi:10.3892/mmr.2014.2789

February-2015 Volume 11 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

February-2015 Volume 11 Issue 2

Full Size Image

Article

Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation

Authors:
- Wei‑Yan Yao
- Yu‑Fen Zhou
- Ai‑Hua Qian
- Yong‑Ping Zhang
- Min‑Min Qiao
- Zu‑Kang Zhai
- Yao‑Zong Yuan
- Song‑Lin Yang
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, P.R. China, Department of Plastic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, P.R. China
Pages: 1416-1420
|
Published online on: October 27, 2014

https://doi.org/10.3892/mmr.2014.2789
Expand metrics +

Abstract

Severe acute pancreatitis (SAP) accounts for up to 20% of acute pancreatitis (AP) cases. The absence of effective treatment options has resulted in a high rate of morbidity and mortality. Emodin is a major component of the Chinese herb rhubarb, which has been widely used in the treatment of numerous diseases, including inflammation and cancer. There are a limited number of studies however, that have investigated the effectiveness of emodin in the treatment of SAP. The present study used a rat model of SAP, to investigate the effect and molecular mechanisms of emodin treatment. Administration of emodin was identified to significantly attenuate SAP, as determined by serum amylase analysis and histological assessment of edema, vacuolization, inflammation and necrosis (P<0.01). Furthermore, treatment with emodin markedly inhibited nuclear factor (NF)‑κB DNA‑binding activity (P<0.01) and the serum expression levels of tumor necrosis factor‑α, interleukin (IL)‑6 and IL‑1β (P<0.05). This attenuation was associated with decreased malondialdehyde and increased superoxide dismutase levels in the pancreatic tissues and serum (P<0.05). This study indicated that administration of exogenous emodin had therapeutic effects on the severity of SAP. The mechanism may be due to inhibition of NF‑κB activation resulting in an antioxidation response, which can subsequently suppress the expression of cytokines.

View Figures

View References

1	Makhija R and Kingsnorth AN: Cytokine storm in acute pancreatitis. J Hepatobiliary Pancreat Surg. 9:401–410. 2002. View Article : Google Scholar : PubMed/NCBI
2	Fujimoto H, Nakamura E, Okuyama E and Ishibashi M: Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activity. Chem Pharm Bull (Tokyo). 52:1005–1008. 2004. View Article : Google Scholar
3	Srinivas G, Babykutty S, Sathiadevan PP and Srinivas P: Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med Res Rev. 27:591–608. 2007. View Article : Google Scholar
4	Braumann C, Tangermann J, Jacobi CA, Muller JM and Dubiel W: Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini Rev Med Chem. 8:421–428. 2008. View Article : Google Scholar : PubMed/NCBI
5	Wu Y, Tu X, Lin G, et al: Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. Life Sc. 81:1332–1338. 2007. View Article : Google Scholar
6	Yucel M, Kucuk A, Bayraktar AC, Tosun M, Yalcinkaya S, Hatipoglu NK, Erkasap N and Kavutcu M: Protective effects of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate in bladder ischemia-reperfusion injury in rats. Mol Biol Rep. 40:5733–5740. 2013. View Article : Google Scholar : PubMed/NCBI
7	Schmidt J, Lewandrowsi K, Warshaw AL, Compton CC and Rattner DW: Morphometric characteristics and homogeneity of a new model of acute pancreatitis in the rat. Int J Pancreatol. 12:41–51. 1992.PubMed/NCBI
8	Lu JS, Liu JX, Zhang WY, et al: Preventive effects of emodin on cerebral ischemia injury and expression of the inflammatory factors in rats with cerebral ischemia. Zhongguo Zhong Yao Za Zhi. 30:1939–1943. 2005.(In Chinese).
9	Tang T, Yin L, Yang J and Shan G: Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur J Pharmacol. 567:177–185. 2007. View Article : Google Scholar : PubMed/NCBI
10	Wang G, Sun B, Gao Y, Meng QH and Jiang HC: An experimental study of emodin assisted early enteral nutrition for the treatment of severe acute pancreatitis. Hepatogastroenterology. 55:33–40. 2008.PubMed/NCBI
11	Gong Z, Yuan Y, Lou K, et al: Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats. Pancreas. 25:154–160. 2002. View Article : Google Scholar : PubMed/NCBI
12	Wu JX, Xu JY and Yuan YZ: Effect of emodin and sandostatin on metabolism of eicosanoids in acute necrotizing pancreatitis. World J Gastroenterol. 6:293–294. 2000.
13	Gutierrez PT, Folch-Puy E, Bulbena O and Closa D: Oxidised lipids present in ascitic fluid interfere with the regulation of the macrophages during acute pancreatitis, promoting an exacerbation of the inflammatory response. Gut. 57:642–648. 2008. View Article : Google Scholar : PubMed/NCBI
14	Abu-Hilal M, McPhail MJ, Marchand L and Johnson CD: Malondialdehyde and superoxide dismutase as potential markers of severity in acute pancreatitis. JOP. 7:185–192. 2006.PubMed/NCBI
15	Ji LL, Gomez-Cabrera MC and Vina J: Role of nuclear factor kappaB and mitogen-activated protein kinase signaling in exercise-induced antioxidant enzyme adaptation. Appl Physiol Nutr Metab. 32:930–935. 2007. View Article : Google Scholar : PubMed/NCBI
16	Mingyan E, Hongli L, Shufeng L and Bo Y: Effects of pyrrolidine dithiocarbamate on antioxidant enzymes in cardiomyopathy induced by adriamycin in rats. Cardiology. 111:119–125. 2008. View Article : Google Scholar : PubMed/NCBI
17	Surh YJ: NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities. Asia Pac J Clin Nutr. 17:269–272. 2008.PubMed/NCBI
18	Jaworek J, Nawrot-Porabka K, Leja-Szpak A, et al: Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol. 58:65–80. 2007.
19	Lawinski M, Sledzinski Z, Kubasik-Juraniec J, et al: Does resveratrol prevent free radical-induced acute pancreatitis? Pancreas. 31:43–47. 2005. View Article : Google Scholar : PubMed/NCBI
20	Wereszczynska-Siemiatkowska U, Mroczko B, Siemiatkowski A, et al: The importance of interleukin 18, glutathione peroxidase, and selenium concentration changes in acute pancreatitis. Dig Dis Sci. 49:642–650. 2004. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Related Articles