Novel IL-6-secreting γδT cells increased in patients with atherosclerotic cerebral infarction

He,Youdi; Ma,Ning; Xing,Chen; Wang,Xiaoqian; Xiao,He; Zheng,Mingke; Han,Gencheng; Chen,Guojiang; Hou,Chunmei; Shen,Beifen; Li,Yan; Jiang,Zhenyu; Wang,Renxi; Hu,Wenli

doi:10.3892/mmr.2014.2796

February-2015 Volume 11 Issue 2

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February-2015 Volume 11 Issue 2

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Article

Novel IL-6-secreting γδT cells increased in patients with atherosclerotic cerebral infarction

Authors:
- Youdi He
- Ning Ma
- Chen Xing
- Xiaoqian Wang
- He Xiao
- Mingke Zheng
- Gencheng Han
- Guojiang Chen
- Chunmei Hou
- Beifen Shen
- Yan Li
- Zhenyu Jiang
- Renxi Wang
- Wenli Hu
View Affiliations / Copyright

Affiliations: Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China, Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing 100850, P.R. China, Department of Rheumatology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
Pages: 1497-1503
|
Published online on: October 29, 2014

https://doi.org/10.3892/mmr.2014.2796
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Abstract

Mounting evidence has suggested that inflammation associated with interleukin (IL)‑6 and T‑helper (Th)17 cells, has a role in the development of atherosclerotic cerebral infarction (ACI). However, it remains unclear which population of cells determines the levels of IL‑6, and the role of IL‑6‑secreting cells in inducing Th17 cell production. In the present study, IL‑6 levels were determined in patients with ACI, by ELISA. The percentage of CD3+T, CD4+T, CD8+T, CD11c+ dendritic cells and γδT cells were determined by flow cytometry, and the correlation between cytokine IL‑6 and γδT cells was determined by statistical analysis. An in vitro culture assay was used to determine whether γδT cells secreted high levels of IL‑6, and induced production of Th17 cells. The patients with ACI had significantly higher levels of IL‑6 and γδT cells. Furthermore, γδT cells were associated with the secretion of a high level of IL‑6 in patients with ACI. These results indicate that γδT cells are novel IL‑6‑secreting cells, which from then on were known as γδT6 cells. In addition, the novel γδT6 cells induced Th17‑cell production, and this induction was dependent on IL‑6. Novel γδT6 cells increased the induction of Th17‑cell production in patients with ACI. The results of the present study suggest that novel γδT6 cells may be a target for strategic therapies of ACI.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Novel IL-6-secreting γδT cells increased in patients with atherosclerotic cerebral infarction

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