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Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells

  • Authors:
    • Hongwei Peng
    • Xiao-Xue Ke
    • Renjian Hu
    • Liqun Yang
    • Hongjuan Cui
    • Yuquan Wei
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cancer Biotherapy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 881-886
    |
    Published online on: October 29, 2014
       https://doi.org/10.3892/mmr.2014.2809
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Abstract

Neuroblastoma is a common solid malignant tumor of the sympathetic nervous system, which contributes to 15% of cancer‑related mortality in children. The differentiation status of neuroblastoma is correlated with clinical outcome, and the induction of differentiation thus constitutes a therapeutic approach in this disease. However, the molecular mechanisms that control the differentiation of neuroblastoma remain poorly understood. The present study aimed to define whether GATA3 is involved in the differentiation of neuroblastoma cells. The results demonstrated that GATA3 is a prognostic marker for survival in patients with neuroblastoma, and that high‑level GATA3 expression is associated with increased self‑renewal and proliferation of neuroblastoma cells. Retinoic acid treatment led to GATA3 downregulation together with neuronal differentiation, suppression of cell proliferation and inhibition of tumorigenecity in neuroblastoma cells. These findings suggest that GATA3 is a key regulator of neuroblastoma differentiation, and provide a novel potential therapeutic strategy for the induction of neuroblastoma differentiation.
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Copy and paste a formatted citation
Spandidos Publications style
Peng H, Ke X, Hu R, Yang L, Cui H and Wei Y: Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells. Mol Med Rep 11: 881-886, 2015.
APA
Peng, H., Ke, X., Hu, R., Yang, L., Cui, H., & Wei, Y. (2015). Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells. Molecular Medicine Reports, 11, 881-886. https://doi.org/10.3892/mmr.2014.2809
MLA
Peng, H., Ke, X., Hu, R., Yang, L., Cui, H., Wei, Y."Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells". Molecular Medicine Reports 11.2 (2015): 881-886.
Chicago
Peng, H., Ke, X., Hu, R., Yang, L., Cui, H., Wei, Y."Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells". Molecular Medicine Reports 11, no. 2 (2015): 881-886. https://doi.org/10.3892/mmr.2014.2809
Copy and paste a formatted citation
x
Spandidos Publications style
Peng H, Ke X, Hu R, Yang L, Cui H and Wei Y: Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells. Mol Med Rep 11: 881-886, 2015.
APA
Peng, H., Ke, X., Hu, R., Yang, L., Cui, H., & Wei, Y. (2015). Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells. Molecular Medicine Reports, 11, 881-886. https://doi.org/10.3892/mmr.2014.2809
MLA
Peng, H., Ke, X., Hu, R., Yang, L., Cui, H., Wei, Y."Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells". Molecular Medicine Reports 11.2 (2015): 881-886.
Chicago
Peng, H., Ke, X., Hu, R., Yang, L., Cui, H., Wei, Y."Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells". Molecular Medicine Reports 11, no. 2 (2015): 881-886. https://doi.org/10.3892/mmr.2014.2809
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