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Article

Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ

  • Authors:
    • Weiguo Sui
    • Ruohan Zhang
    • Jiejing Chen
    • Huiyan He
    • Zhenzhen Cui
    • Minglin Ou
    • Wuxian Li
    • Suwen Qi
    • Jingli Wen
    • Xiuhua Lin
    • Yong Dai
  • View Affiliations / Copyright

    Affiliations: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China, Key Laboratory of Laboratory Medical Diagnostics of Education Ministry, Chongqing Medical University, Chongqing, Sichuan 400016, P.R. China, Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen, Guangdong 518020, P.R. China
  • Pages: 1391-1399
    |
    Published online on: October 31, 2014
       https://doi.org/10.3892/mmr.2014.2828
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Abstract

Down sydrome (DS) is a relatively frequent chromosomal disorder, which has no safe and effective method of prenatal diagnosis to date. The present study was designed to identify DS biomarkers. We quantified the changes in the umbilical cord blood protein levels between DS-affected and healthy (control) pregnant females using isobaric tags for relative and absolute quantification (iTRAQ) and Gene Ontology (GO) analysis. A total of 505 proteins were identified, and of these, five proteins showed significantly different concentrations between the DS and the control group. These proteins may thus be relevant to DS and constitute potential DS biomarkers.
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Copy and paste a formatted citation
Spandidos Publications style
Sui W, Zhang R, Chen J, He H, Cui Z, Ou M, Li W, Qi S, Wen J, Lin X, Lin X, et al: Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ. Mol Med Rep 11: 1391-1399, 2015.
APA
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M. ... Dai, Y. (2015). Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ. Molecular Medicine Reports, 11, 1391-1399. https://doi.org/10.3892/mmr.2014.2828
MLA
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M., Li, W., Qi, S., Wen, J., Lin, X., Dai, Y."Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ". Molecular Medicine Reports 11.2 (2015): 1391-1399.
Chicago
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M., Li, W., Qi, S., Wen, J., Lin, X., Dai, Y."Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ". Molecular Medicine Reports 11, no. 2 (2015): 1391-1399. https://doi.org/10.3892/mmr.2014.2828
Copy and paste a formatted citation
x
Spandidos Publications style
Sui W, Zhang R, Chen J, He H, Cui Z, Ou M, Li W, Qi S, Wen J, Lin X, Lin X, et al: Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ. Mol Med Rep 11: 1391-1399, 2015.
APA
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M. ... Dai, Y. (2015). Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ. Molecular Medicine Reports, 11, 1391-1399. https://doi.org/10.3892/mmr.2014.2828
MLA
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M., Li, W., Qi, S., Wen, J., Lin, X., Dai, Y."Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ". Molecular Medicine Reports 11.2 (2015): 1391-1399.
Chicago
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M., Li, W., Qi, S., Wen, J., Lin, X., Dai, Y."Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ". Molecular Medicine Reports 11, no. 2 (2015): 1391-1399. https://doi.org/10.3892/mmr.2014.2828
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