Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2015 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2015 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome

  • Authors:
    • Xiang‑Dong Kong
    • Ning Liu
    • Xue‑Ju Xu
    • Zhen‑Hua Zhao
    • Miao Jiang
  • View Affiliations / Copyright

    Affiliations: Prenatal Diagnosis Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Paediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 1235-1239
    |
    Published online on: November 4, 2014
       https://doi.org/10.3892/mmr.2014.2855
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to identify the genes on human chromosome 21 (HC21) that may serve important functions in the pathogenesis of Down syndrome (DS). The microarray data GSE5390 were obtained from the Gene Expression Omnibus database, which contained 7 DS and 8 healthy normal samples. The data were then normalized and the differentially expressed genes (DEGs) were identified using the LIMMA package and Bonferroni correction. Furthermore, the DEGs underwent clustering and gene ontology analysis. Additionally, the locations of the DEGs on HC21 were confirmed using human genome 19 in the University of California, Santa Cruz Interaction Browser. A total of 25 upregulated and 275 downregulated genes were screened between DS and healthy samples with a false discovery rate of <0.05 and |logFC|>1. The expression levels of these genes in the two samples were different. In addition, the up‑ and downregulated genes were markedly enriched in organic substance biological processes (P=4.48x10‑10) and cell‑cell signaling (P=0.000227). Furthermore, 17 overexpressed genes were identified on the 21q21‑22 area, including COL6A2, TTC3 and ABCG1. Together, these observations suggest that 17 upregulated genes on HC21 may be involved in the development of DS and provide the basis for understanding this disability.
View Figures

Figure 1

View References

1 

Hobbs CA, Sherman SL, Yi P, et al: Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. Am J Hum Genet. 67:623–630. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Fuentes JJ, Genescà L, Kingsbury TJ, et al: DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet. 9:1681–1690. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Bittles AH, Bower C, Hussain R and Glasson EJ: The four ages of Down syndrome. Eur J Public Health. 17:221–225. 2007. View Article : Google Scholar

4 

de Hingh YC, van der Vossen PW, Gemen EF, et al: Intrinsic abnormalities of lymphocyte counts in children with down syndrome. J Pediatr. 147:744–747. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Hattori M, Fujiyama A, Taylor TD, et al: Chromosome 21 mapping and sequency consortium: The DNA sequence of human chromosome 21. Nature. 405:311–319. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Kuhn DE, Nuovo GJ, Terry AV Jr, Martin MM, et al: Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun. 370:473–477. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Barrett T, Troup DB, Wilhite SE, et al: NCBI GEO: mining tens of millions of expression profiles - database and tools update. Nucleic Acids Res. 35:D760–D765. 2007. View Article : Google Scholar

8 

Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ and Bahn S: Gene expression profiling in the adult Down syndrome brain. Genomics. 90:647–660. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Smyth GK and Speed T: Normalization of cDNA microarray data. Methods. 31:265–273. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Smyth GK: Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Gentleman R, Carey V, Huber W, Irizarry R and Dudoit S: Springer; New York: pp. 397–420. 2005, View Article : Google Scholar

11 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B Met. 57:289–300. 1995.

12 

Benjamini Y: Discovering the false discovery rate. J Roy Stat Soc B. 72:405–416. 2010. View Article : Google Scholar

13 

Ester M, Kriegel HP, Sander J and Xu X: A density-based algorithm for discovering clusters in large spatial databases with noise. In: Proceedings of the Second International conference on Knowledge Discovery and Data Mining (KDD-96); Association for the Advancement of Artificial Intelligence; Palo Alto, CA: pp. 226–231. 1996

14 

Eisen MB, Spellman PT, Brown PO and Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 95:14863–14868. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Saldanha AJ: Java Treeview - extensible visualization of microarray data. Bioinformatics. 20:3246–3248. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Ruxton GD: The unequal variance t-test is an underused alternative to Student’s t-test and the Mann-Whitney U test. Behav Ecol. 17:688–690. 2006. View Article : Google Scholar

17 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Ashburner M, Ball CA, Blake JA, et al: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Wong CK, Vaske CJ, Ng S, Sanborn JZ, Benz SC, Haussler D and Stuart JM: The UCSC Interaction Browser: multidimensional data views in pathway context. Nucleic Acids Res. 41:W218–W224. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Reynolds LE, Watson AR, Baker M, et al: Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome. Nature. 465:813–817. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Zhang RZ, Sabatelli P, Pan TC, et al: Effects on collagen VI mRNA stability and microfibrillar assembly of three COL6A2 mutations in two families with Ullrich congenital muscular dystrophy. J Biol Chem. 277:43557–43564. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Grossman TR, Gamliel A, Wessells RJ, et al: Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 7:e10023442011. View Article : Google Scholar : PubMed/NCBI

23 

Karkheiran S, Krebs CE, Makarov V, et al: Identification of COL6A2 mutations in progressive myoclonus epilepsy syndrome. Hum Genet. 132:275–283. 2013. View Article : Google Scholar

24 

Vaughan AM and Oram JF: ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins. J Biol Chem. 280:30150–30157. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Yvan-Charvet L, Pagler TA, Seimon TA, et al: ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 106:1861–1869. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Yvan-Charvet L, Wang N and Tall AR: Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol. 30:139–143. 2010. View Article : Google Scholar :

27 

Toker A: TTC3 ubiquitination terminates Akt-ivation. Dev Cell. 17:752–754. 2009. View Article : Google Scholar

28 

Oegema R, de Klein A, Verkerk AJ, et al: Distinctive phenotypic abnormalities associated with submicroscopic 21q22 deletion including DYRK1A. Mol Syndromol. 1:113–120. 2010.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kong XD, Liu N, Xu XJ, Zhao ZH and Jiang M: Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome. Mol Med Rep 11: 1235-1239, 2015.
APA
Kong, X., Liu, N., Xu, X., Zhao, Z., & Jiang, M. (2015). Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome. Molecular Medicine Reports, 11, 1235-1239. https://doi.org/10.3892/mmr.2014.2855
MLA
Kong, X., Liu, N., Xu, X., Zhao, Z., Jiang, M."Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome". Molecular Medicine Reports 11.2 (2015): 1235-1239.
Chicago
Kong, X., Liu, N., Xu, X., Zhao, Z., Jiang, M."Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome". Molecular Medicine Reports 11, no. 2 (2015): 1235-1239. https://doi.org/10.3892/mmr.2014.2855
Copy and paste a formatted citation
x
Spandidos Publications style
Kong XD, Liu N, Xu XJ, Zhao ZH and Jiang M: Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome. Mol Med Rep 11: 1235-1239, 2015.
APA
Kong, X., Liu, N., Xu, X., Zhao, Z., & Jiang, M. (2015). Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome. Molecular Medicine Reports, 11, 1235-1239. https://doi.org/10.3892/mmr.2014.2855
MLA
Kong, X., Liu, N., Xu, X., Zhao, Z., Jiang, M."Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome". Molecular Medicine Reports 11.2 (2015): 1235-1239.
Chicago
Kong, X., Liu, N., Xu, X., Zhao, Z., Jiang, M."Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome". Molecular Medicine Reports 11, no. 2 (2015): 1235-1239. https://doi.org/10.3892/mmr.2014.2855
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team