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Article

miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1

  • Authors:
    • Jie Ruan
    • Xinguang Liu
    • Xingdong Xiong
    • Chunlong Zhang
    • Jiangbin  Li
    • Huiling Zheng
    • Chirong Huang
    • Qiong Shi
    • Yaguang Weng

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Chongqing Medical University, Chongqing 400016, P.R. China, Institute of Aging Research, Guangdong Medical College, Dongguan, Guandong 523808, P.R. China, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan, Guandong 523808, P.R. China
  • Pages: 1334-1339
    |
    Published online on: November 5, 2014
       https://doi.org/10.3892/mmr.2014.2865
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Abstract

microRNAs (miRNAs) have been reported to be involved in various human diseases. They may have uses in diagnosis and as therapeutic targets, thus the discovery of novel miRNAs has the potential to provide clinical tools or shed light on novel mechanisms. In the current study, miR‑107 was revealed to be downregulated in chronic myeloid leukemia cells. Overexpression of miR‑107 in K562 and KCL‑22 chronic myeloid leukemia cells promotes erythroid differentiation, while having no effect on cell proliferation. Further bioinformatics predicted that one target of miR‑107 may be Cacna2d1, a calcium channel protein. A luciferase reporter assay and quantitative polymerase chain reaction were utilized to confirm that Cacna2d1 is a target molecule of miR-107. The effect of miR‑107 on K562 and KCL‑22 cells was mediated through the downregulation of Cacna2d1, as rescued expression of Cacna2d1 reversed the effects of miR‑107. In summary, the current study identified a novel miRNA that is involved in chronic myeloid leukemia cell erythroid differentiation and the associated mechanisms, making it a potential therapeutic target in the treatment of chronic myeloid leukemia.
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Copy and paste a formatted citation
Spandidos Publications style
Ruan J, Liu X, Xiong X, Zhang C, Li J, Zheng H, Huang C, Shi Q and Weng Y: miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1. Mol Med Rep 11: 1334-1339, 2015.
APA
Ruan, J., Liu, X., Xiong, X., Zhang, C., Li, J., Zheng, H. ... Weng, Y. (2015). miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1. Molecular Medicine Reports, 11, 1334-1339. https://doi.org/10.3892/mmr.2014.2865
MLA
Ruan, J., Liu, X., Xiong, X., Zhang, C., Li, J., Zheng, H., Huang, C., Shi, Q., Weng, Y."miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1". Molecular Medicine Reports 11.2 (2015): 1334-1339.
Chicago
Ruan, J., Liu, X., Xiong, X., Zhang, C., Li, J., Zheng, H., Huang, C., Shi, Q., Weng, Y."miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1". Molecular Medicine Reports 11, no. 2 (2015): 1334-1339. https://doi.org/10.3892/mmr.2014.2865
Copy and paste a formatted citation
x
Spandidos Publications style
Ruan J, Liu X, Xiong X, Zhang C, Li J, Zheng H, Huang C, Shi Q and Weng Y: miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1. Mol Med Rep 11: 1334-1339, 2015.
APA
Ruan, J., Liu, X., Xiong, X., Zhang, C., Li, J., Zheng, H. ... Weng, Y. (2015). miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1. Molecular Medicine Reports, 11, 1334-1339. https://doi.org/10.3892/mmr.2014.2865
MLA
Ruan, J., Liu, X., Xiong, X., Zhang, C., Li, J., Zheng, H., Huang, C., Shi, Q., Weng, Y."miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1". Molecular Medicine Reports 11.2 (2015): 1334-1339.
Chicago
Ruan, J., Liu, X., Xiong, X., Zhang, C., Li, J., Zheng, H., Huang, C., Shi, Q., Weng, Y."miR‑107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1". Molecular Medicine Reports 11, no. 2 (2015): 1334-1339. https://doi.org/10.3892/mmr.2014.2865
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