Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2015 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2015 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis

  • Authors:
    • Hong Liu
    • Yuechen Han
    • Shuai Wang
    • Haibo Wang
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250000, P.R. China, Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250000, P.R. China
  • Pages: 1127-1131
    |
    Published online on: November 6, 2014
       https://doi.org/10.3892/mmr.2014.2877
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to examine the role of the mitochondrial (mt) DNA common deletion (CD) 4977 (mtDNACD4977) in the hair shaft in patients with presbycusis. A total of 87 individuals with presbycusis and 95 normal‑hearing controls were selected based on strict audiometric criteria. Nested polymerase chain reaction (PCR), sequencing and quantitative (q)PCR were used to examine the expression levels of mtDNACD4977 in the hair shaft in presbycusis. Nested PCR of the hair shaft demonstrated that 8/95 cases with normal hearing were found to be positive for mtDNACD4977, as compared with 59/87 cases in the presbycusis group. The mtDNACD4977 was positive in 22/43 cases with mild‑to‑moderate hearing loss, 25/31 cases with moderate‑to‑severe, severe hearing loss, and 12/13 cases with profound deafness. Statistically significant differences in mtDNACD4977 expression were identified among all of the groups (P<0.001). The sequencing and qPCR assays demonstrated a trend towards an increase in the mean CD level of mtDNACD4977 with a more severe hearing loss at 8 kHz (r=0.778, P<0.001) and all ranges of frequency (r=0.858, P<0.001). In conclusion, the present study demonstrates a correlation between mtDNACD4977 in the human hair shaft and the severity of hearing loss in presbycusis.
View Figures

Figure 1

Figure 2

View References

1 

Mao Z, Zhao L, Pu L, et al: How well can centenarians hear? PLoS One. 8:e655652013. View Article : Google Scholar : PubMed/NCBI

2 

Sprinzl GM and Riechelmann H: Current trends in treating hearing loss in elderly people: a review of the technology and treatment options-a mini-review. Gerontology. 56:351–358. 2010. View Article : Google Scholar

3 

Markaryan A, Nelson EG and Hinojosa R: Quantification of the mitochondrial DNA common deletion in presbycusis. Laryngoscope. 119:1184–1189. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Gendron SP, Mallet JD, Bastien N and Rochette PJ: Mitochondrial DNA common deletion in the human eye: a relation with corneal aging. Mech Ageing Dev. 133:68–74. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Nie H, Shu H, Vartak R, et al: Mitochondrial common deletion, a potential biomarker for cancer occurrence, is selected against in cancer background: a meta-analysis of 38 studies. PLoS One. 8:e679532013. View Article : Google Scholar : PubMed/NCBI

6 

Torrell H, Montaña E, Abasolo N, et al: Mitochondrial DNA (mtDNA) in brain samples from patients with major psychiatric disorders: gene expression profiles, mtDNA content and presence of the mtDNA common deletion. Am J Med Genet B Neuropsychiatr Genet. 162B:213–223. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Zheng Y, Luo X, Zhu J, et al: Mitochondrial DNA 4977 bp deletion is a common phenomenon in hair and increases with age. Bosn J Basic Med Sci. 12:187–192. 2012.PubMed/NCBI

8 

Pesce V, Cormio A, Marangi LC, et al: Depletion of mitochondrial DNA in the skeletal muscle of two cirrhotic patients with severe asthenia. Gene. 286:143–148. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Obara-Moszynska M, Maceluch J, Bobkowski W, et al: A novel mitochondrial DNA deletion in a patient with Kearns-Sayre syndrome: a late-onset of the fatal cardiac conduction deficit and cardiomyopathy accompanying long-term rGH treatment. BMC Pediatr. 13:272013. View Article : Google Scholar : PubMed/NCBI

10 

Taylor RW, Schaefer AM, McFarland R, Maddison P and Turnbull DM: A novel mitochondrial DNA tRNA(Ile) (A4267G) mutation in a sporadic patient with mitochondrial myopathy. Neuromuscul Disord. 12:659–664. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Love RL and Bird P: Cochlear implantation in mitochondrial deafness due to A7445G mutation. Cochlear Implants Int. 14:28–31. 2013. View Article : Google Scholar

12 

Hao H, Bonilla E, Manfredi G, DiMauro S and Moraes CT: Segregation patterns of a novel mutation in the mitochondrial tRNA glutamic acid gene associated with myopathy and diabetes mellitus. Am J Hum Genet. 56:1017–1025. 1995.PubMed/NCBI

13 

Fischel-Ghodsian N, Bykhovskaya Y, Taylor K, et al: Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations. Hear Res. 110:147–154. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Bai U and Seidman MD: A specific mitochondrial DNA deletion (mtDNA4977) is identified in a pedigree of a family with hearing loss. Hear Res. 154:73–80. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Dai P, Yang W, Jiang S, et al: Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis. Acta Otolaryngol. 124:130–136. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Yamasoba T, Someya S, Yamada C, et al: Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res. 226:185–193. 2007. View Article : Google Scholar

17 

Bekaert B, Larmuseau MH, Vanhove MP, Opdekamp A and Decorte R: Automated DNA extraction of single dog hairs without roots for mitochondrial DNA analysis. Forensic Sci Int Genet. 6:277–281. 2012. View Article : Google Scholar

18 

Harman D: Free radical theory of aging. Mutat Res. 275:257–266. 1992. View Article : Google Scholar : PubMed/NCBI

19 

Mecocci P, MacGarvey U, Kaufman AE, et al: Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol. 34:609–616. 1993. View Article : Google Scholar : PubMed/NCBI

20 

Lagouge M and Larsson NG: The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med. 273:529–543. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Chen B, Zhong Y, Peng W, Sun Y and Kong WJ: Age-related changes in the central auditory system: comparison of D-galactose-induced aging rats and naturally aging rats. Brain Res. 1344:43–53. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Zhong Y, Hu YJ, Yang Y, et al: Contribution of common deletion to total deletion burden in mitochondrial DNA from inner ear of d-galactose-induced aging rats. Mutat Res. 712:11–19. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Kim EJ, Kim SY, Yun HJ, et al: Detection and quantification of a radiation-associated mitochondrial DNA deletion by a nested real-time PCR in human peripheral lymphocytes. Mutat Res. 749:53–59. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Sequeira A, Martin MV, Rollins B, et al: Mitochondrial mutations and polymorphisms in psychiatric disorders. Front Genet. 3:1032012. View Article : Google Scholar : PubMed/NCBI

25 

Niu R, Yoshida M and Ling F: Increases in mitochondrial DNA content and 4977-bp deletion upon ATM/Chk2 checkpoint activation in HeLa cells. PLoS One. 7:e405722012. View Article : Google Scholar : PubMed/NCBI

26 

Yuan YY, Dai P, Zhu XH, et al: Etiologic analysis of severe to profound hearing loss patients from Chifeng city in Inner Mongolia. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 44:292–296. 2009.(In Chinese). PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu H, Han Y, Wang S and Wang H: Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis. Mol Med Rep 11: 1127-1131, 2015.
APA
Liu, H., Han, Y., Wang, S., & Wang, H. (2015). Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis. Molecular Medicine Reports, 11, 1127-1131. https://doi.org/10.3892/mmr.2014.2877
MLA
Liu, H., Han, Y., Wang, S., Wang, H."Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis". Molecular Medicine Reports 11.2 (2015): 1127-1131.
Chicago
Liu, H., Han, Y., Wang, S., Wang, H."Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis". Molecular Medicine Reports 11, no. 2 (2015): 1127-1131. https://doi.org/10.3892/mmr.2014.2877
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Han Y, Wang S and Wang H: Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis. Mol Med Rep 11: 1127-1131, 2015.
APA
Liu, H., Han, Y., Wang, S., & Wang, H. (2015). Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis. Molecular Medicine Reports, 11, 1127-1131. https://doi.org/10.3892/mmr.2014.2877
MLA
Liu, H., Han, Y., Wang, S., Wang, H."Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis". Molecular Medicine Reports 11.2 (2015): 1127-1131.
Chicago
Liu, H., Han, Y., Wang, S., Wang, H."Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis". Molecular Medicine Reports 11, no. 2 (2015): 1127-1131. https://doi.org/10.3892/mmr.2014.2877
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team