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Article Open Access

Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells

  • Authors:
    • Liang Yin
    • Hongdang Qu
    • Qiming Chen
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1595-1600
    |
    Published online on: November 19, 2014
       https://doi.org/10.3892/mmr.2014.2975
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Abstract

Previous studies have suggested that common antigens that exist in neurons and tumor cells trigger cross immunoreaction, which attacks the neurons and tumor cells simultaneously. This action leads to paraneoplastic symptoms and slowed tumor growth. The present study co‑cultured peripheral blood mononuclear cells (PBMCs) from anti‑Hu antibody‑associated patients with paraneoplastic neurological syndrome (PNS) and the small cell lung cancer cell line NCI‑H446 (H446) in vitro. In the PNS group, no significant difference was observed in the proliferation index of PBMCs and H446 cells between the mixed or separate cultures. The proportion of CD4+ T cells in patients with PNS (76.54±3.96%) was significantly higher (P<0.05) compared with the healthy control individuals (51.75±17.3%). In conclusion, the sensitized specific T cells in the PBMCs of PNS patients predominantly comprised of CD4+ T cells, which had no inhibitory effect on small cell lung cancer cells in vitro.
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Copy and paste a formatted citation
Spandidos Publications style
Yin L, Qu H and Chen Q: Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells. Mol Med Rep 11: 1595-1600, 2015.
APA
Yin, L., Qu, H., & Chen, Q. (2015). Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells. Molecular Medicine Reports, 11, 1595-1600. https://doi.org/10.3892/mmr.2014.2975
MLA
Yin, L., Qu, H., Chen, Q."Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells". Molecular Medicine Reports 11.3 (2015): 1595-1600.
Chicago
Yin, L., Qu, H., Chen, Q."Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells". Molecular Medicine Reports 11, no. 3 (2015): 1595-1600. https://doi.org/10.3892/mmr.2014.2975
Copy and paste a formatted citation
x
Spandidos Publications style
Yin L, Qu H and Chen Q: Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells. Mol Med Rep 11: 1595-1600, 2015.
APA
Yin, L., Qu, H., & Chen, Q. (2015). Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells. Molecular Medicine Reports, 11, 1595-1600. https://doi.org/10.3892/mmr.2014.2975
MLA
Yin, L., Qu, H., Chen, Q."Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells". Molecular Medicine Reports 11.3 (2015): 1595-1600.
Chicago
Yin, L., Qu, H., Chen, Q."Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells". Molecular Medicine Reports 11, no. 3 (2015): 1595-1600. https://doi.org/10.3892/mmr.2014.2975
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