Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2015 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2015 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element

  • Authors:
    • Li Sun
    • Lixin Wang
    • Zhe Wang
    • Wei He
    • Shuping Zhang
    • Wenli Guo
    • Yi Qian
    • Hong Ji
    • Haiqin Rong
    • Sijin Liu
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco‑Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China, Shandong Institute of Endocrine and Metabolic Diseases, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, P.R. China
  • Pages: 3129-3133
    |
    Published online on: November 27, 2014
       https://doi.org/10.3892/mmr.2014.3015
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cadmium (Cd) is a heavy metal that has detrimental effects on various organs. The widespread contamination of Cd in the environment, crops and food sources poses a severe threat to human health. Acute toxicities of Cd have been extensively investigated; however, the health impact of chronic low‑dose exposure to Cd, particularly exposure under non‑toxic concentrations, has yet to be elucidated. Furthermore, the toxic threshold of Cd is currently unknown. Ferroportin is the only known iron exporter in vertebrate cells, and it has an essential role in controlling iron egress from cells. To the best of our knowledge, the present study is the first to verify the regulation of ferroportin by Cd. Treatment with low‑dose Cd (i.e. at sublethal concentrations, without undermining cell viability) increased the protein expression of ferroportin in macrophages, and this was associated with depleted cellular iron levels. Mechanistic investigations revealed that Cd modulated the ferroportin concentration at the translational level, via the iron responsive element located at the 5'‑untranslated region of ferroportin. In conclusion, these data provide evidence for the molecular basis by which Cd alters cellular iron availability through elevating concentrations of ferroportin.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Hetherington L, Brown T, Benham A, Bide T, Lusty P, Hards V, Hannis S and Idoine N: World Mineral Production 2002–06. Keyworth, Nottingham: British Geological Survey; 2008

2 

Satarug S, Garrett SH, Sens MA and Sens DA: Cadmium, environmental exposure, and health outcomes. Cien Saude Colet. 16:2587–2602. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Veljkovic AR, Nikolic RS, Kocic GM, et al: Protective effects of glutathione and lipoic acid against cadmium-induced oxidative stress in rat’s kidney. Ren Fail. 34:1281–1287. 2012. View Article : Google Scholar

4 

Bernhoft RA: Cadmium toxicity and treatment. Scientific World Journal. 2013:3946522013. View Article : Google Scholar : PubMed/NCBI

5 

Cen YL, Tang LY, Lin Y, Su FX, Wu BH and Ren ZF: Association between urinary cadmium and clinicopathological characteristics of breast cancer. Zhonghua Zhong Liu Za Zhi. 35:632–635. 2013.(In Chinese). PubMed/NCBI

6 

Riederer AM, Belova A, George BJ and Anastas PT: Urinary cadmium in the 1999–2008 U.S. National Health and Nutrition Examination Survey (NHANES). Environ Sci Technol. 47:1137–1147. 2013. View Article : Google Scholar

7 

Satarug S and Moore MR: Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect. 112:1099–1103. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Brama M, Politi L, Santini P, Migliaccio S and Scandurra R: Cadmium-induced apoptosis and necrosis in human osteoblasts: role of caspases and mitogen-activated protein kinases pathways. J Endocrinol Invest. 35:198–208. 2012.

9 

Angenard G, Muczynski V, Coffigny H, et al: Cadmium increases human fetal germ cell apoptosis. Environ Health Perspect. 118:331–337. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Gordon WL: The absorption, transport and storage of iron. Queens Med Mag (1972). 38:30–35. 1945.

11 

Ganz T: Hepcidin and iron regulation, 10 years later. Blood. 117:4425–4433. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Nemeth E, Tuttle MS, Powelson J, et al: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 306:2090–2093. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Galy B, Ferring-Appel D, Becker C, et al: Iron regulatory proteins control a mucosal block to intestinal iron absorption. Cell Rep. 3:844–857. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Casey JL, Hentze MW, Koeller DM, et al: Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science. 240:924–928. 1988. View Article : Google Scholar : PubMed/NCBI

15 

Lymboussaki A, Pignatti E, Montosi G, Garuti C, Haile DJ and Pietrangelo A: The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. J Hepatol. 39:710–715. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Drakesmith H and Prentice AM: Hepcidin and the iron-infection axis. Science. 338:768–772. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Evstatiev R and Gasche C: Iron sensing and signalling. Gut. 61:933–952. 2012. View Article : Google Scholar

18 

Cazzola M: Genetic disorders of iron overload and the novel “ferroportin disease”. Haematologica. 88:721–724. 2003.PubMed/NCBI

19 

Beutler E, Barton JC, Felitti VJ, et al: Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans. Blood Cells Mol Dis. 31:305–309. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Griffiths WJ, Mayr R, McFarlane I, et al: Clinical presentation and molecular pathophysiology of autosomal dominant hemochromatosis caused by a novel ferroportin mutation. Hepatology. 51:788–795. 2010.

21 

Maeß MB, Wittig B, Cignarella A and Lorkowski S: Reduced PMA enhances the responsiveness of transfected THP-1 macrophages to polarizing stimuli. J Immunol Method. 402:76–81. 2014. View Article : Google Scholar

22 

Qu G, Zhang C, Yuan L, et al: Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling. Nanoscale. 4:2239–2244. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Prus E and Fibach E: Flow cytometry measurement of the labile iron pool in human hematopoietic cells. Cytometry A. 73:22–27. 2008. View Article : Google Scholar

24 

Abboud S and Haile DJ: A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 275:19906–19912. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Donovan A, Brownlie A, Zhou Y, et al: Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 403:776–781. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Donovan A, Lima CA, Pinkus JL, et al: The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 1:191–200. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Weiss G: Iron and immunity: a double-edged sword. Eur J Clin Invest. 32(Suppl 1): 70–78. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Ganz T: Macrophages and systemic iron homeostasis. J Innate Immun. 4:446–453. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Martelli A and Moulis JM: Zinc and cadmium specifically interfere with RNA-binding activity of human iron regulatory protein 1. J Inorg Biochem. 98:1413–1420. 2004. View Article : Google Scholar : PubMed/NCBI

30 

De Smet H, Blust R and Moens L: Cadmium-binding to transferrin in the plasma of the common carp Cyprinus carpio. Comp Biochem Physiol C Toxicol Pharmacol. 128:45–53. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Brzóska MM and Rogalska J: Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats. Toxicol Appl Pharmacol. 272:208–220. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Breuer W, Shvartsman M and Cabantchik ZI: Intracellular labile iron. Int J Biochem Cell Biol. 40:350–354. 2008. View Article : Google Scholar

33 

Pinnix ZK, Miller LD, Wang W, et al: Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med. 2:43ra562010. View Article : Google Scholar : PubMed/NCBI

34 

Chen J, Shi YH and Li MY: Changes in transferrin and hepcidin genes expression in the liver of the fish Pseudosciaena crocea following exposure to cadmium. Arch Toxicol. 82:525–530. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Buerge-Weirich D, Hari R, Xue H, Behra P and Sigg L: Adsorption of Cu, Cd, and Ni on goethite in the presence of natural groundwater ligands. Environ Sci Technol. 36:328–336. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Gunshin H, Mackenzie B, Berger UV, et al: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388:482–488. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Horiguchi H: Anemia induced by cadmium intoxication. Nihon Eiseigaku Zasshi. 62:888–904. 2007.(In Chinese). View Article : Google Scholar : PubMed/NCBI

38 

Park BY and Chung J: Cadmium increases ferroportin-1 gene expression in J774 macrophage cells via the production of reactive oxygen species. Nutr Res Pract. 3:192–199. 2009. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun L, Wang L, Wang Z, He W, Zhang S, Guo W, Qian Y, Ji H, Rong H, Liu S, Liu S, et al: Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element. Mol Med Rep 11: 3129-3133, 2015.
APA
Sun, L., Wang, L., Wang, Z., He, W., Zhang, S., Guo, W. ... Liu, S. (2015). Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element. Molecular Medicine Reports, 11, 3129-3133. https://doi.org/10.3892/mmr.2014.3015
MLA
Sun, L., Wang, L., Wang, Z., He, W., Zhang, S., Guo, W., Qian, Y., Ji, H., Rong, H., Liu, S."Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element". Molecular Medicine Reports 11.4 (2015): 3129-3133.
Chicago
Sun, L., Wang, L., Wang, Z., He, W., Zhang, S., Guo, W., Qian, Y., Ji, H., Rong, H., Liu, S."Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element". Molecular Medicine Reports 11, no. 4 (2015): 3129-3133. https://doi.org/10.3892/mmr.2014.3015
Copy and paste a formatted citation
x
Spandidos Publications style
Sun L, Wang L, Wang Z, He W, Zhang S, Guo W, Qian Y, Ji H, Rong H, Liu S, Liu S, et al: Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element. Mol Med Rep 11: 3129-3133, 2015.
APA
Sun, L., Wang, L., Wang, Z., He, W., Zhang, S., Guo, W. ... Liu, S. (2015). Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element. Molecular Medicine Reports, 11, 3129-3133. https://doi.org/10.3892/mmr.2014.3015
MLA
Sun, L., Wang, L., Wang, Z., He, W., Zhang, S., Guo, W., Qian, Y., Ji, H., Rong, H., Liu, S."Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element". Molecular Medicine Reports 11.4 (2015): 3129-3133.
Chicago
Sun, L., Wang, L., Wang, Z., He, W., Zhang, S., Guo, W., Qian, Y., Ji, H., Rong, H., Liu, S."Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element". Molecular Medicine Reports 11, no. 4 (2015): 3129-3133. https://doi.org/10.3892/mmr.2014.3015
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team