Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells

Chen,Tunan; Yi,Liang; Li,Fei; Hu,Rong; Hu,Shengli; Yin,Yi; Lan,Chuan; Li,Zhao; Fu,Chuhua; Cao,Liu; Chen,Zhi; Xian,Jishu; Feng,Hua

doi:10.3892/mmr.2014.3027

April-2015 Volume 11 Issue 4

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April-2015 Volume 11 Issue 4

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Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells

Authors:
- Tunan Chen
- Liang Yi
- Fei Li
- Rong Hu
- Shengli Hu
- Yi Yin
- Chuan Lan
- Zhao Li
- Chuhua Fu
- Liu Cao
- Zhi Chen
- Jishu Xian
- Hua Feng
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Southwest Hospital, Chongqing 400038, P.R. China, Department of Neurosurgery, Daping Hospital, Chongqing 400042, P.R. China

Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
Pages: 2407-2412
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Published online on: December 1, 2014

https://doi.org/10.3892/mmr.2014.3027
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Abstract

Glioma‑initiating cells are a small population of cells that have the ability to undergo self‑renewal and initiate tumorigenesis. In the present study, the potential role of salinomycin, a polyether antibiotic, on the suppression of glioma cell growth was investigated. GL261 glioma cells were maintained in a stem‑cell‑like status [GL261 neurospheres (GL261‑NS)] or induced for differentiation [GL261 adherent cells (GL261‑AC)]. It was demonstrated that salinomycin significantly reduced the cell viability of GL261‑NS and GL261‑AC cells in a dose‑dependent manner, with a more substantial inhibition of GL261‑NS proliferation (P<0.05). The inhibitory effect of salinomycin on cell growth was more effective than that of 1‑(4‑amino‑2‑methyl‑5‑pyrimid l)‑methyl‑3‑(2‑chloroethyl)‑3‑nitrosourea hydrochloride and vincristine (P<0.05). Salinomycin depleted GL261‑NS from tumorspheres and induced cell apoptosis. In addition, salinomycin prolonged the median survival time of glioma‑bearing mice (P<0.05). Therefore, the present study indicated that salinomycin may preferentially inhibit glioma‑initiated cell growth by inducing apoptosis, suggesting that salinomycin may provide a valuable therapeutic strategy for the treatment of malignant glioma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells

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