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Article

Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer

  • Authors:
    • Linlin Wang
    • Ting Geng
    • Xiaosun Guo
    • Jie Liu
    • Pei Zhang
    • Dong Yang
    • Juan Li
    • Shuwen Yu
    • Yuping Sun
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China, Department of Oncology, Weifang Medical University, Weifang, Shandong 261053, P.R. China, Department of Pathophysiology, Medicine School of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Pharmacy, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China
  • Pages: 2789-2796
    |
    Published online on: December 2, 2014
       https://doi.org/10.3892/mmr.2014.3029
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Abstract

The development of strategies for the inhibition of non‑small cell lung cancer (NSCLC) progression and metastasis have been mainly unsuccessful, in part due to insufficient mechanistic understanding of the disease. In the current study, the critical role of the co‑expression of immunoglobulin‑like transcript 4 (ILT4) and its ligands, angiopoietin‑like proteins (ANGPTLs), in the development of NSCLC was demonstrated. ILT4 and ANGPTL2 or ANGPTL5 were found to be co‑expressed in the five NSCLC cell lines that were investigated at the mRNA and protein level. Upon up‑ or downregulation of ILT4, the expression of ANGPTL2 was increased or reduced, respectively, while the expression of ANGPTL5 was unaffected. The co‑expression of ILT4 and ANGPTL2/ANGPTL5 was detected in human primary NSCLC tissues using immunohistochemical analysis. In total, 114 lung cancer specimens were included in the study; high expression of ILT4, ANGPTL2 and ANGPTL5 was observed in 58.8, 45.6 and 55.3%, respectively. The expression of ILT4 was found to be significantly correlated with a high expression level of ANGPTL2 (R=0.466, P=0.004); however, it was not correlated with the expression of ANGPTL5 (R=0.142, P=0.131). In ILT4‑positive samples, cases with ANGPTL2‑positive expression levels presented greater levels of lymph node metastasis (P=0.011) and shorter overall survival times (P=0.045). In addition, cases with ANGPTL5‑positive expression presented poor overall survival rates (P=0.040). By contrast, in the ILT4‑negative cases, no statistically significant differences were identified in the overall survival rates between samples with high and low expression of ANGPTL2 or ANGPTL5. In conclusion, the present study demonstrated the presence of interaction among ILT4 and ANGPTLs, which may be important in NSCLC progression. Therefore, the blockade of ANGPTLs or ILT4 may be an effective therapeutic approach for NSCLC treatment.
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1 

Postmus PE: Chemotherapy for non-small cell lung cancer: the experience of the Lung Cancer Cooperative Group of the European Organization for Research and Treatment of Cancer. Chest. 113(Suppl): 28S–31S. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR and Borges L: The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol. 28:3423–3434. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Borges L and Cosman D: LIRs/ILTs/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cells. Cytokine Growth Factor Rev. 11:209–217. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Colonna M, Samaridis J, Cella M, et al: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol. 160:3096–3100. 1998.PubMed/NCBI

5 

Colonna M, Navarro F, Bellón T, et al: A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med. 186:1809–1818. 1997. View Article : Google Scholar

6 

de Waal Malefyt R, Haanen J, Spits H, et al: Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med. 174:915–924. 1991. View Article : Google Scholar : PubMed/NCBI

7 

Lepin EJ, Bastin JM, Allan DS, et al: Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors. Eur J Immunol. 30:3552–3561. 2000. View Article : Google Scholar

8 

Riteau B, Rouas-Freiss N, Menier C, Paul P, Dausset J and Carosella ED: HLA-G2, -G3, and -G4 isoforms expressed as nonmature cell surface glycoproteins inhibit NK and antigen-specific CTL cytolysis. J Immunol. 166:5018–5026. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Manavalan JS, Rossi PC, Vlad G, et al: High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol. 11:245–258. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Sun Y, Liu J, Gao P, Wang Y and Liu C: Expression of Ig-like transcript 4 inhibitory receptor in human non-small cell lung cancer. Chest. 134:783–788. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Zheng J, Umikawa M, Cui C, et al: Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature. 485:656–660. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Tabata M, Kadomatsu T, Fukuhara S, et al: Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 10:178–188. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Zhang CC, Kaba M, Ge G, et al: Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med. 12:240–245. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Hato T, Tabata M and Oike Y: The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med. 18:6–14. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Oike Y, Yasunaga K and Suda T: Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis. Int J Hematol. 80:21–28. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Aoi J, Endo M, Kadomatsu T, et al: Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Cancer Res. 71:7502–7512. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Sasaki H, Suzuki A, Shitara M, et al: Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer. Oncol Lett. 4:1325–1328. 2012.PubMed/NCBI

18 

Kikuchi R, Tsuda H, Kozaki K, et al: Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer. Cancer Res. 68:5067–5075. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Teicher BA: Searching for molecular targets in sarcoma. Biochem Pharmacol. 84:1–10. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Endo M, Nakano M, Kadomatsu T, et al: Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis. Cancer Res. 72:1784–1794. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Drake AC, Khoury M, Leskov I, et al: Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ−/− (NSG) mice. PLoS One. 6:e183822011. View Article : Google Scholar

22 

Khoury M, Drake A, Chen Q, Dong D, Leskov I, et al: Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev. 20:1371–1381. 2011. View Article : Google Scholar :

23 

Miida T and Hirayama S: Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events. Curr Opin Lipidol. 21:70–75. 2010. View Article : Google Scholar

24 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumors. 7th edition. John Wiley & Sons; Hoboken, NJ: 2009

25 

Huang XF, Han J, Hu XT and He C: Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncol Rep. 27:1541–1547. 2012.PubMed/NCBI

26 

Marchiò S, Soster M, Cardaci S, et al: A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. EMBO Mol Med. 4:1156–1175. 2012. View Article : Google Scholar

27 

Hato T, Tabata M and Oike Y: The role of angiopoitin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med. 18:6–14. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Sporn MB and Roberts AB: Autocrine growth factors and cancer. Nature. 313:745–747. 1985. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Geng T, Guo X, Liu J, Zhang P, Yang D, Li J, Yu S and Sun Y: Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer. Mol Med Rep 11: 2789-2796, 2015.
APA
Wang, L., Geng, T., Guo, X., Liu, J., Zhang, P., Yang, D. ... Sun, Y. (2015). Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer. Molecular Medicine Reports, 11, 2789-2796. https://doi.org/10.3892/mmr.2014.3029
MLA
Wang, L., Geng, T., Guo, X., Liu, J., Zhang, P., Yang, D., Li, J., Yu, S., Sun, Y."Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer". Molecular Medicine Reports 11.4 (2015): 2789-2796.
Chicago
Wang, L., Geng, T., Guo, X., Liu, J., Zhang, P., Yang, D., Li, J., Yu, S., Sun, Y."Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer". Molecular Medicine Reports 11, no. 4 (2015): 2789-2796. https://doi.org/10.3892/mmr.2014.3029
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Geng T, Guo X, Liu J, Zhang P, Yang D, Li J, Yu S and Sun Y: Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer. Mol Med Rep 11: 2789-2796, 2015.
APA
Wang, L., Geng, T., Guo, X., Liu, J., Zhang, P., Yang, D. ... Sun, Y. (2015). Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer. Molecular Medicine Reports, 11, 2789-2796. https://doi.org/10.3892/mmr.2014.3029
MLA
Wang, L., Geng, T., Guo, X., Liu, J., Zhang, P., Yang, D., Li, J., Yu, S., Sun, Y."Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer". Molecular Medicine Reports 11.4 (2015): 2789-2796.
Chicago
Wang, L., Geng, T., Guo, X., Liu, J., Zhang, P., Yang, D., Li, J., Yu, S., Sun, Y."Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer". Molecular Medicine Reports 11, no. 4 (2015): 2789-2796. https://doi.org/10.3892/mmr.2014.3029
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