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Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells

  • Authors:
    • Zhibing Ai
    • Chengyan Li
    • Longti Li
    • Guohou He
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
    Copyright: © Ai et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2429-2434
    |
    Published online on: December 3, 2014
       https://doi.org/10.3892/mmr.2014.3034
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Abstract

The natural product resveratrol possesses diverse biological activities, including anti‑inflammatory, anti‑oxidant, anti‑cancer and anti‑aging effects in multiple organisms. The neuroprotective role of resveratrol has recently been reported in a cell model of amyloid (A)β(25‑35)‑induced neurotoxic injury using PC12 cells. However, the pathomechanism by which resveratrol inhibits neuronal apoptosis has remained to be elucidated. The present study therefore aimed to confirm the neuroprotective effects of resveratrol in an Aβ(25‑35)‑induced model of neurotoxicity in PC12 cells and elucidate the mechanisms underlying these effects. It was demonstrated that resveratrol exerted neuronal protection through inhibition of cell apoptosis, which was associated with an increased acetylation level of p53. In accordance with this effect, when the acetylation level of p53 was decreased by p53 acetylation inhibitor pifithrin‑α, the protective effects of resveratrol were abrogated. In conclusion, it was revealed that resveratrol inhibited Aβ(25‑35)‑induced cell apoptosis via the acetylation of p53 in PC12 cells.
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Copy and paste a formatted citation
Spandidos Publications style
Ai Z, Li C, Li L and He G: Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Mol Med Rep 11: 2429-2434, 2015.
APA
Ai, Z., Li, C., Li, L., & He, G. (2015). Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Molecular Medicine Reports, 11, 2429-2434. https://doi.org/10.3892/mmr.2014.3034
MLA
Ai, Z., Li, C., Li, L., He, G."Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells". Molecular Medicine Reports 11.4 (2015): 2429-2434.
Chicago
Ai, Z., Li, C., Li, L., He, G."Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells". Molecular Medicine Reports 11, no. 4 (2015): 2429-2434. https://doi.org/10.3892/mmr.2014.3034
Copy and paste a formatted citation
x
Spandidos Publications style
Ai Z, Li C, Li L and He G: Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Mol Med Rep 11: 2429-2434, 2015.
APA
Ai, Z., Li, C., Li, L., & He, G. (2015). Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Molecular Medicine Reports, 11, 2429-2434. https://doi.org/10.3892/mmr.2014.3034
MLA
Ai, Z., Li, C., Li, L., He, G."Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells". Molecular Medicine Reports 11.4 (2015): 2429-2434.
Chicago
Ai, Z., Li, C., Li, L., He, G."Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells". Molecular Medicine Reports 11, no. 4 (2015): 2429-2434. https://doi.org/10.3892/mmr.2014.3034
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