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Article

Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity

  • Authors:
    • Borbála Kiss
    • Magdolna Szántó
    • Mónika Szklenár
    • Attila Brunyánszki
    • Tamás Marosvölgyi
    • Eszter Sárosi
    • Éva Remenyik
    • Pál Gergely
    • László Virág
    • Tamás Decsi
    • Ralph Rühl
    • Peter Bai
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, University of Debrecen, H-4032 Debrecen, Hungary, Department of Medical Chemistry, University of Debrecen, H-4032 Debrecen, Hungary, Paprika Bioanalytics Bt., H‑4032 Debrecen, Hungary, Department of Pediatrics, University of Pécs, H-7623 Pécs, Hungary, Department of Biochemistry and Molecular Biology, University of Debrecen, H‑4032 Debrecen, Hungary
  • Pages: 2861-2867
    |
    Published online on: December 4, 2014
       https://doi.org/10.3892/mmr.2014.3044
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Abstract

Poly(ADP‑ribose) polymerase (PARP)‑1 is a pro‑inflammatory protein. The inhibition of PARP‑1 reduces the activity of numerous pro‑inflammatory transcription factors, which results in the reduced production of pro‑inflammatory cytokines, chemokines, matrix metalloproteinases and inducible nitric oxide synthase, culminating in reduced inflammation of the skin and other organs. The aim of the present study was to investigate the effects of the deletion of PARP‑1 expression on polyunsaturated fatty acids (PUFA), and PUFA metabolite composition, in mice under control conditions or undergoing an oxazolone (OXA)‑induced contact hypersensitivity reaction (CHS). CHS was elicited using OXA in both the PARP‑1+/+ and PARP‑1/ mice, and the concentration of PUFAs and PUFA metabolites in the diseased skin were assessed using lipidomics experiments. The levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were shown to be increased in the PARP‑1/ mice, as compared with the control, unsensitized PARP‑1+/+ mice. In addition, higher expression levels of fatty acid binding protein 7 (FABP7) were detected in the PARP‑1/ mice. FABP7 is considered to be a specific carrier of DHA and EPA. Furthermore, the levels of the metabolites of DHA and EPA (considered mainly as anti‑inflammatory or pro‑resolving factors) were higher, as compared with the metabolites of arachidonic acid (considered mainly pro‑inflammatory), both in the unsensitized control and OXA‑sensitized PARP‑1/ mice. The results of the present study suggest that the genetic deletion of PARP‑1 may affect the PUFA‑homeostasis of the skin, resulting in an anti‑inflammatory milieu, including increased DHA and EPA levels, and DHA and EPA metabolite levels. This may be an important component of the anti‑inflammatory action of PARP‑1 inhibition.
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1 

Amé JC, Spenlehauer C and de Murcia G: The PARP superfamily. Bioessays. 26:882–893. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Szántó M, Brunyánszki A, Kiss B, et al: Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein. Cell Mol Life Sci. 69:4079–4092. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Mehrotra P, Hollenbeck A, Riley JP, et al: Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates T(H)2 differentiation and allergic airway disease. J Allergy Clin Immunol. 131:521–531. 2013. View Article : Google Scholar

4 

Mehrotra P, Riley JP, Patel R, et al: PARP-14 functions as a transcriptional switch for Stat6-dependent gene activation. J Biol Chem. 286:1767–1776. 2011. View Article : Google Scholar :

5 

Levaot N, Voytyuk O, Dimitriou I, et al: Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell. 147:1324–1339. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Bai P and Virág L: Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes. FEBS Lett. 586:3771–3777. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Brunyánszki A, Hegedus C, Szántó M, et al: Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress. J Invest Dermatol. 130:2629–2637. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Virág L, Szabó E, Bakondi E, et al: Nitric oxide-peroxynitrite-poly (ADP-ribose) polymerase pathway in the skin. Exp Dermatol. 11:189–202. 2002. View Article : Google Scholar

9 

Bakondi E, Gönczi M, Szabó E, et al: Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes. J Invest Dermatol. 121:88–95. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Selle A, Ullrich O, Harnacke K and Hass R: Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1. Exp Gerontol. 42:554–562. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Aldinucci A, Gerlini G, Fossati S, et al: A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. J Immunol. 179:305–312. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Mocchegiani E, Muzzioli M, Giacconi R, et al: Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply. Mech Ageing Dev. 124:459–468. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Zerfaoui M, Errami Y, Naura AS, et al: Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. J Immunol. 185:1894–1902. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Rolli J, Rosenblatt-Velin N, Li J, et al: Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. PLoS One. 5:e126872010. View Article : Google Scholar : PubMed/NCBI

15 

Eaves-Pyles T, Murthy K, Liaudet L, et al: Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J Immunol. 166:1248–1260. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Liaudet L, Deb A, Pacher P, et al: The Flagellin-TLR5 axis: Therapeutic opportunities. Drug News Perspect. 15:397–409. 2002. View Article : Google Scholar

17 

Liaudet L, Murthy KG, Mabley JG, et al: Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Infect Immun. 70:192–198. 2002. View Article : Google Scholar

18 

Liaudet L, Szabó C, Evgenov OV, et al: Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock. 19:131–137. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Murthy KG, Deb A, Goonesekera S, Szabó C and Salzman AL: Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro. J Biol Chem. 279:5667–5675. 2004. View Article : Google Scholar

20 

Pacher P, Beckman JS and Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 87:315–424. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Grabbe S and Schwarz T: Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today. 19:37–44. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Grabbe S, Steinert M, Mahnke K, et al: Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest. 98:1158–1164. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Olmos A, Giner RM, Recio MC, et al: Effects of plant alkylphenols on cytokine production, tyrosine nitration and inflammatory damage in the efferent phase of contact hypersensitivity. Br J Pharmacol. 152:366–373. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Haskó G, Mabley JG, Németh ZH, et al: Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. Mol Med. 8:283–289. 2002.PubMed/NCBI

25 

Soriano F, Virág L, Jagtap P, et al: Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 7:108–113. 2001. View Article : Google Scholar

26 

Bai P, Hegedus C, Szabó E, et al: Poly(ADP-ribose) polymerase mediates inflammation in a mouse model of contact hypersensitivity. J Invest Dermatol. 129:234–238. 2009. View Article : Google Scholar

27 

de Murcia JM, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver FJ, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P and de Murcia G: Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA. 94:7303–7307. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Szklenar M, Kalkowski J, Stangl V, Lorenz M and Rühl R: Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. J Vasc Res. 50:372–382. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Rühl R: Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom. 20:2497–2504. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Szabó E, Virág L, Bakondi E, et al: Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity. J Invest Dermatol. 117:74–80. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Elabdeen HR, Mustafa M, Szklenar M, et al: Ratio of pro-resolving and pro-inflammatory lipid mediator precursors as potential markers for aggressive periodontitis. PLoS One. 8:e708382013. View Article : Google Scholar : PubMed/NCBI

32 

Lin Y, Tang X, Zhu Y, Shu T and Han X: Identification of PARP-1 as one of the transcription factors binding to the repressor element in the promoter region of COX-2. Arch Biochem Biophys. 505:123–129. 2011. View Article : Google Scholar

33 

Hanhoff T, Lücke C and Spener F: Insights into binding of fatty acids by fatty acid binding proteins. Mol Cell Biochem. 239:45–54. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Bai P and Cantó C: The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease. Cell Metab. 16:290–295. 2012.PubMed/NCBI

35 

Szántó M, Brunyánszki A, Márton J, et al: Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels. Biochem Biophys Acta. 1842:594–602. 2014.

36 

Tomobe YI, Morizawa K, Tsuchida M, et al: Dietary docosahexaenoic acid suppresses inflammation and immunoresponses in contact hypersensitivity reaction in mice. Lipids. 35:61–69. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Abba C, Mussa PP, Vercelli A and Raviri G: Essential fatty acids supplementation in different-stage atopic dogs fed on a controlled diet. J Anim Physiol Anim Nutr (Berl). 89:203–207. 2005. View Article : Google Scholar

38 

Rühl R, Koch C, Marosvölgyi T, et al: Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. Br J Nutr. 99:1239–1246. 2008. View Article : Google Scholar

39 

Virág L and Szabó C: The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 54:375–429. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Madsen P, Rasmussen HH, Leffers H, Honoré B and Celis JE: Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. J Invest Dermatol. 99:299–305. 1992. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kiss B, Szántó M, Szklenár M, Brunyánszki A, Marosvölgyi T, Sárosi E, Remenyik É, Gergely P, Virág L, Decsi T, Decsi T, et al: Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity. Mol Med Rep 11: 2861-2867, 2015.
APA
Kiss, B., Szántó, M., Szklenár, M., Brunyánszki, A., Marosvölgyi, T., Sárosi, E. ... Bai, P. (2015). Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity. Molecular Medicine Reports, 11, 2861-2867. https://doi.org/10.3892/mmr.2014.3044
MLA
Kiss, B., Szántó, M., Szklenár, M., Brunyánszki, A., Marosvölgyi, T., Sárosi, E., Remenyik, É., Gergely, P., Virág, L., Decsi, T., Rühl, R., Bai, P."Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity". Molecular Medicine Reports 11.4 (2015): 2861-2867.
Chicago
Kiss, B., Szántó, M., Szklenár, M., Brunyánszki, A., Marosvölgyi, T., Sárosi, E., Remenyik, É., Gergely, P., Virág, L., Decsi, T., Rühl, R., Bai, P."Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity". Molecular Medicine Reports 11, no. 4 (2015): 2861-2867. https://doi.org/10.3892/mmr.2014.3044
Copy and paste a formatted citation
x
Spandidos Publications style
Kiss B, Szántó M, Szklenár M, Brunyánszki A, Marosvölgyi T, Sárosi E, Remenyik É, Gergely P, Virág L, Decsi T, Decsi T, et al: Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity. Mol Med Rep 11: 2861-2867, 2015.
APA
Kiss, B., Szántó, M., Szklenár, M., Brunyánszki, A., Marosvölgyi, T., Sárosi, E. ... Bai, P. (2015). Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity. Molecular Medicine Reports, 11, 2861-2867. https://doi.org/10.3892/mmr.2014.3044
MLA
Kiss, B., Szántó, M., Szklenár, M., Brunyánszki, A., Marosvölgyi, T., Sárosi, E., Remenyik, É., Gergely, P., Virág, L., Decsi, T., Rühl, R., Bai, P."Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity". Molecular Medicine Reports 11.4 (2015): 2861-2867.
Chicago
Kiss, B., Szántó, M., Szklenár, M., Brunyánszki, A., Marosvölgyi, T., Sárosi, E., Remenyik, É., Gergely, P., Virág, L., Decsi, T., Rühl, R., Bai, P."Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity". Molecular Medicine Reports 11, no. 4 (2015): 2861-2867. https://doi.org/10.3892/mmr.2014.3044
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