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Article Open Access

Molecular responses of radiation-induced liver damage in rats

  • Authors:
    • Wei   Cheng
    • Lei Xiao
    • Aimudula Ainiwaer
    • Yunlian Wang
    • Ge Wu
    • Rui Mao
    • Ying Yang
    • Yongxing Bao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2592-2600
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    Published online on: December 4, 2014
       https://doi.org/10.3892/mmr.2014.3051
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Abstract

The aim of the present study was to investigate the molecular responses involved in radiation‑induced liver damage (RILD). Sprague‑Dawley rats (6‑weeks‑old) were irradiated once at a dose of 20 Gy to the right upper quadrant of the abdomen. The rats were then sacrificed 3 days and 1, 2, 4, 8 and 12 weeks after irradiation and rats, which were not exposed to irradiation were used as controls. Weight measurements and blood was obtained from the rats and liver tissues were collected for histological and apoptotic analysis. Immunohistochemistry, reverse transcription quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis were performed to measure the expression levels of mRNAs and proteins, respectively. The serum levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were increased significantly in the RILD rats. Histological investigation revealed the proliferation of collagen and the formation of fibrotic tissue 12 weeks after irradiation. Apoptotic cells were observed predominantly 2 and 4 weeks after irradiation. The immunohistochemistry, RT‑qPCR and western blot analysis all revealed the same pattern of changes in the expression levels of the molecules assessed. The expression levels of transforming growth factor‑β1 (TGF‑β1), nuclear factor (NF)‑κB65, mothers against decapentaplegic homolog 3 (Smad3) and Smad7 and connective tissue growth factor were increased during the recovery period following irradiation up to 12 weeks. The expression levels of tumor necrosis factor‑α, Smad7 and Smad4 were only increased during the early phase (first 4 weeks) of recovery following irradiation. In the RILD rat model, the molecular responses indicated that the TGF‑β1/Smads and NF‑κB65 signaling pathways are involved in the mechanism of RILD recovery.
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View References

1 

Liang SX, Zhu XD, Xu ZY, Zhu J, Zhao JD, Lu HJ, et al: Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: The risk factors and hepatic radiation tolerance. Int J Radiat Oncol Biol Phys. 65:426–434. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Gil-Alzugaray B, Chopitea A, Iñarrairaegui M, Bilbao JI, Rodriguez-Fraile M, Rodriguez J, et al: Prognostic factors and prevention of radioembolization-induced liver disease. Hepatology. 57:1078–1087. 2013. View Article : Google Scholar

3 

Guha C and Kavanagh BD: Hepatic radiation toxicity: Avoidance and amelioration. Semin Radiat Oncol. 21:256–263. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Shi SR, Key ME and Kalra KL: Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem. 39:741–748. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Xu ZY, Liang SX, Zhu J, Zhu XD, Zhao JD, Lu HJ, et al: Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma. Int J Radiat Oncol Biol Phys. 65:189–195. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Cheng JC, Wu JK, Huang CM, Liu HS, Huang DY, Cheng SH, et al: Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: Dosimetric analysis and implication. Int J Radiat Oncol Biol Phys. 54:156–162. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Emami B, Lyman J, Brown A, et al: Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 21:109–122. 1991. View Article : Google Scholar : PubMed/NCBI

9 

Milano MT, Constine LS and Okunieff P: Normal tissue tolerance dose metrics for radiation therapy of major organs. Semin Radiat Oncol. 17:131–140. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Dancygier H and Schirmacher P: Radiation-induced liver damage. Clinical Hepatology. Dancygier H: Springer; New York, NY, USA: pp. 2032010

11 

Rave-Frank M, Malik IA, Christiansen H, Naz N, Sultan S, Amanzada A, et al: Rat model of fractionated (2 Gy/day) 60 Gy irradiation of the liver: long-term effects. Radiat Environ Biophys. 52:321–338. 2013. View Article : Google Scholar

12 

Erbil Y, Oztezcan S, Giris M, Barbaros U, Olgac V, Bilge H, et al: The effect of glutamine on radiation-induced organ damage. Life Sci. 4:376–382. 2005. View Article : Google Scholar

13 

Adaramoye O, Ogungbenro B, Anyaegbu O and Fafunso M: Protective effects of extracts of vernonia amygdalina, hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats. J Radiat Res. 49:123–131. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Chi K, Liao C, Chand C, et al: Angiogenic blockade and radiotherapy in hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 1:188–193. 2010. View Article : Google Scholar

15 

Gencel O, Naziroqlu M, Celik O, Yalman K, Bayram D, et al: Selenium and vitamin E modulates radiation-induced liver toxicity in pregnant and nonpregnant rat: effects of colemanite and hematite shielding. Biol Trace Elem Res. 135:253–63. 2010. View Article : Google Scholar

16 

Ingold JA, Reed GB, Kaplan HS and Bagshaw MA: Radiation Hepatitis. Am J Roentgenol Radium Ther Nucl Med. 93:200–208. 1965.PubMed/NCBI

17 

Reed GB Jr and Cox AJ Jr: The human liver after radiation injury. A form of veno-occlusive disease. Am J Pathol. 48:597–611. 1966.PubMed/NCBI

18 

Friedman SL: Mechanisms of hepatic fibrogenesis. Gastroenterology. 134:1655–1669. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Taimr P, Higuchi H, Kocova E, et al: Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology. 37:87–95. 2003. View Article : Google Scholar

20 

Wright M, Issa R, Smart D, et al: Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology. 121:685–698. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Anscher MS, Chen L, Rabbani Z, et al: Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys. 62:255–259. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Anscher MS, Crocker IR and Jirtle RL: Transforming growth factor-beta 1 expression in irradiated liver. Radiat Res. 122:77–85. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Kong FM, Anscher M, Xiong Z, et al: Elevated circulating transforming growth factor-1 levels decreased after radiotherapy in patients with lung cancer, cervical cancer and Hodgkin’s disease: A possible tumor marker. Int J Radiat Oncol Biol Phys. 32:2391995. View Article : Google Scholar

24 

Novakov-Jiresova A, Van Gameren MM, Coppes RP, et al: Transforming growth factor-beta plasma dynamics and post-irradiation lung injury in lung cancer patients. Radiother Oncol. 71:183–189. 2004. View Article : Google Scholar

25 

Hakenjos L, Bamberg M and Rodemann H: TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype. Int J Radiat Biol. 76:503–509. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Border WA, Brees D and Noble NA: Transforming growth factor-beta and extracellular matrix deposition in the kidney. Contrib Nephrol. 107:140–145. 1994.PubMed/NCBI

27 

Peters H, Border WA and Noble NA: Targeting TGF-beta overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade. Kidney Int. 54:1570–1580. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Border WA and Ruoslahti E: Transforming growth factor-β in disease: The dark side of tissue repair. J Clin Invest. 90:1–7. 1992. View Article : Google Scholar : PubMed/NCBI

29 

Bartram U and Speer CP: The role of transforming growth factor beta in lung development and disease. Chest. 125:754–765. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Anscher MS, Kong FM and Jirtle RL: The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy. Lung Cancer. 19:109–120. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Rabbani ZN, Anscher MS, Zhang X, et al: Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. Int J Radiat Oncol Biol Phys. 57:563–572. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Rabbani ZN, Anscher MS, Golson ML, et al: Overexpression of extracellular superoxide dismutase reduces severity of radiation-induced lung toxicity through downregulation of the TGF-β1 signal transduction pathway. Int J Radiat Oncol Biol Phys. 57:S158–S159. 2003. View Article : Google Scholar

33 

Anscher MS, Kong FM, Andrews K, et al: Plasma transforming growth factor β1 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 41:1029–1035. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Anscher MS, Kong FM, Marks LB, et al: Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation- induced pneumonitis. Int J Radiat Oncol Biol Phys. 37:253–258. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Anscher MS, Murase T, Prescott DM, et al: Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis. Int J Radiat Oncol Biol Phys. 30:671–676. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Franko AJ, Sharplin J, Ghahary A, et al: Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and ‘non-fibrosing’ mice during the latent period and early phase after irradiation. Radiat Res. 147:245–256. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Liguang C, Larrier N, Rabbani ZN, et al: Assessment of the protective effect of keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. Int J Radiat Oncol Biol Phys. 57:S1622003. View Article : Google Scholar

38 

Taylor IW and Wrana JL: SnapShot: The TGFbeta pathway interactome. Cell. 133:3782008. View Article : Google Scholar : PubMed/NCBI

39 

Bierie B and Moses HL: Tumour microenvironment: TGF beta: The molecular Jekyll and Hyde of cancer. Nat Rev Cancer. 6:506–520. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Flanders KC, Sullivan CD, Fujii M, et al: Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol. 160:1057–1068. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Peters CA, Stock RG, Cesaretti JA, et al: TGFβ1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 70:752–759. 2008. View Article : Google Scholar

42 

Haydont V, Mathe D, Bourgier C, et al: Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives. Radiother Oncol. 76:219–225. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Haydont V, Riser BL, Aigueperse J, et al: Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: A role for CCN2 and low concentration of TGF-beta1. Am J Physiol Cell Physiol. 294:C1332–C1341. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Riley PA: Free radicals in biology: Oxidative stress and the effects of ionizing radiation. Int J Radiat Biol. 65:27–33. 1994. View Article : Google Scholar : PubMed/NCBI

45 

Barcellos-Hoff MH and Dix TA: Redox-mediated activation of latent transforming growth factor-beta1. Mol Endocrinol. 10:1077–1083. 1996.PubMed/NCBI

46 

Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, et al: Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: downregulation by cAMP. FASEB J. 13:1774–1786. 1999.PubMed/NCBI

47 

Ahmed KM and Li JJ: NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radic Biol Med. 44:1–13. 2008. View Article : Google Scholar :

48 

Hallahan DE, Spriggs DR, Beckett MA, Kufe DW and Weichselbaum RR: Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci USA. 86:10104–10107. 1989. View Article : Google Scholar : PubMed/NCBI

49 

Blonska M, You Y, Geleziunas R and Lin X: Restoration of NFkappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells. Mol Cell Biol. 24:10757–10765. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Baeuerle PA and Henkel T: Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 12:141–179. 1994. View Article : Google Scholar : PubMed/NCBI

51 

Majno PE, Morel P and Mentha G: Mini-review: tumor necrosis factor (TNF) and TNF soluble receptors (TNF-sR) in liver disease and liver transplantation. Swiss Surg. 4:182–185. 1995.PubMed/NCBI

52 

Tello K, Christiansen H, Gürleyen H, et al: Irradiation leads to apoptosis of Kupffer cells by a Hsp27-dependant pathway followed by release of TNF-alpha. Radiat Environ Biophys. 47:389–397. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Franko AJ, Sharplin J, Ghahary A and Barcellos-Hof MH: Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and non-fibrosing mice during the latent period and early phase after irradiation. Radiat Res. 147:245–256. 1997. View Article : Google Scholar : PubMed/NCBI

54 

Geraci JP, Mariano MS and Jackson KL: Radiation hepatology of the rat: time-dependent recovery. Radiat Res. 136:214–221. 1993. View Article : Google Scholar : PubMed/NCBI

55 

Iwamoto KS and McBride WH: Production of 13-hydroxyoctadecadienoic acid and tumor necrosis factor-alpha by murine peritoneal macrophages in response to irradiation. Radiat Res. 139:103–108. 1994. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng W, Xiao L, Ainiwaer A, Wang Y, Wu G, Mao R, Yang Y and Bao Y: Molecular responses of radiation-induced liver damage in rats. Mol Med Rep 11: 2592-2600, 2015.
APA
Cheng, W., Xiao, L., Ainiwaer, A., Wang, Y., Wu, G., Mao, R. ... Bao, Y. (2015). Molecular responses of radiation-induced liver damage in rats. Molecular Medicine Reports, 11, 2592-2600. https://doi.org/10.3892/mmr.2014.3051
MLA
Cheng, W., Xiao, L., Ainiwaer, A., Wang, Y., Wu, G., Mao, R., Yang, Y., Bao, Y."Molecular responses of radiation-induced liver damage in rats". Molecular Medicine Reports 11.4 (2015): 2592-2600.
Chicago
Cheng, W., Xiao, L., Ainiwaer, A., Wang, Y., Wu, G., Mao, R., Yang, Y., Bao, Y."Molecular responses of radiation-induced liver damage in rats". Molecular Medicine Reports 11, no. 4 (2015): 2592-2600. https://doi.org/10.3892/mmr.2014.3051
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng W, Xiao L, Ainiwaer A, Wang Y, Wu G, Mao R, Yang Y and Bao Y: Molecular responses of radiation-induced liver damage in rats. Mol Med Rep 11: 2592-2600, 2015.
APA
Cheng, W., Xiao, L., Ainiwaer, A., Wang, Y., Wu, G., Mao, R. ... Bao, Y. (2015). Molecular responses of radiation-induced liver damage in rats. Molecular Medicine Reports, 11, 2592-2600. https://doi.org/10.3892/mmr.2014.3051
MLA
Cheng, W., Xiao, L., Ainiwaer, A., Wang, Y., Wu, G., Mao, R., Yang, Y., Bao, Y."Molecular responses of radiation-induced liver damage in rats". Molecular Medicine Reports 11.4 (2015): 2592-2600.
Chicago
Cheng, W., Xiao, L., Ainiwaer, A., Wang, Y., Wu, G., Mao, R., Yang, Y., Bao, Y."Molecular responses of radiation-induced liver damage in rats". Molecular Medicine Reports 11, no. 4 (2015): 2592-2600. https://doi.org/10.3892/mmr.2014.3051
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