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Article

Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas

  • Authors:
    • Tiehui Zhang
    • Binhai Zhao
    • Jia Li
    • Chunlei Zhang
    • Hongzhi  Li
    • Jiang Wu
    • Shiming Zhang
    • Guozhen Hui
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Heilongjiang Key Laboratory of Anti‑Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China
  • Pages: 3027-3032
    |
    Published online on: December 8, 2014
       https://doi.org/10.3892/mmr.2014.3062
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Abstract

In general, pituitary tumors are benign with low mitotic activity. Premature senescence has been considered to be a significant mechanism underlying this uniquely benign pituitary tumor. The present study aims to compare the expression of the associated proteins involved in premature senescence pathways among normal, aging and pituitary adenoma cells. We successfully induced the aging pituitary using continuous D‑galactose (D‑gal) injection as well as a prolactin‑secreting pituitary tumor via diethylstilbestrol implants. Compared with normal pituitary cells, the aging pituitary tissues revealed increased expression of IL‑6, C/EBPβ, p53, p21 and p16 and decreased expression of pituitary tumor transforming gene. In contrast, the expression of IL‑6, p21 and p16 was decreased in pituitary tumor cells compared with normal pituitary tissues. Taken together, multiple pathways including IL‑6/C/EBPβ, p53/p21 and p16 were activated in aging pituitary cells in response to D‑gal treatment. However, all these pathways were immune to pituitary tumors treated by chronic estrogen. The findings and the involvement of cytokines in a highly prevalent natural disease model (pituitary adenomas) indicate a potential use of this pathway as a target for effective therapy for tumor silencing and prevention of adenoma progression towards malignancy.
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1 

Kovacs K, Horvath E and Vidal S: Classification of pituitary adenomas. J Neurooncol. 54:121–127. 2001. View Article : Google Scholar

2 

Melmed S: Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest. 112:1603–1618. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Ezzat S and Asa SL: Mechanisms of disease: The pathogenesis of pituitary tumors. Nat Clin Pract Endocrinol Metab. 2:220–230. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Levy A and Lightman S: Molecular defects in the pathogenesis of pituitary tumours. Front Neuroendocrinol. 24:94–127. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Melmed S: Pathogenesis of pituitary tumors. Nat Rev Endocrinol. 7:257–266. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wierinckx A, Raverot G, Nazaret N, Jouanneau E, Auger C, Lachuer J, et al: Proliferation markers of human pituitary tumors: contribution of a genome-wide transcriptome approach. Mol Cell Endocrinol. 326:30–39. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Scheithauer BW, Gaffey TA, Lloyd RV, Sebo TJ, Kovacs KT, Horvath E, et al: Pathobiology of pituitary adenomas and carcinomas. Neurosurgery. 59:341–353. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Arzt E, Chesnokova V, Stalla GK and Melmed S: Pituitary adenoma growth: a model for cellular senescence and cytokine action. Cell Cycle. 8:677–678. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Herbig U, Jobling WA, Chen BP, Chen DJ and Sedivy JM: Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell. 14:501–513. 2004. View Article : Google Scholar : PubMed/NCBI

10 

d’Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al: A DNA damage checkpoint response in telomere-initiated senescence. Nature. 426:194–198. 2003. View Article : Google Scholar

11 

Takai H, Smogorzewska A and de Lange T: DNA damage foci at dysfunctional telomeres. Curr Biol. 13:1549–1556. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Serrano M and Blasco MA: Putting the stress on senescence. Curr Opin Cell Biol. 13:748–753. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, et al: Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 67:10564–10572. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, et al: p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci USA. 105:17498–17503. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, et al: Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci USA. 110:E3331–E3339. PubMed/NCBI

16 

Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, et al: Tumour biology: senescence in premalignant tumours. Nature. 436:6422005. View Article : Google Scholar : PubMed/NCBI

17 

Mooi WJ and Peeper DS: Oncogene-induced cell senescence-halting on the road to cancer. N Engl J Med. 355:1037–1046. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Kuilman T and Peeper DS: Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer. 9:81–94. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Collado M, Blasco MA and Serrano M: Cellular senescence in cancer and aging. Cell. 130:223–233. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, et al: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell. 133:1019–1031. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K, et al: Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol. 19:1383–1391. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Lloyd RV: Estrogen-induced hyperplasia and neoplasia in the rat anterior pituitary gland. An immunohistochemical study. Am J Pathol. 113:198–206. 1983.PubMed/NCBI

23 

Lu J, Zheng YL, Luo L, Wu DM, Sun DX and Feng YJ: Quercetin reverses D-galactose induced neurotoxicity in mouse brain. Behav Brain Res. 171:251–260. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Wu DM, Lu J, Zheng YL, Zhou Z, Shan Q and Ma DF: Purple sweet potato color repairs d-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins. Neurobiol Learn Mem. 90:19–27. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Olanow CW: A radical hypothesis for neurodegeneration. Trends Neurosci. 16:439–444. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Spady TJ, McComb RD and Shull JD: Estrogen action in the regulation of cell proliferation, cell survival, and tumorigenesis in the rat anterior pituitary gland. Endocrine. 11:217–233. 1999. View Article : Google Scholar

27 

Naugler WE and Karin M: The wolf in sheep’s clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 14:109–119. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Spangelo BL, Judd AM, Isakson PC and MacLeod RM: Interleukin-1 stimulates interleukin-6 release from rat anterior pituitary cells in vitro. Endocrinology. 128:2685–2692. 1991. View Article : Google Scholar : PubMed/NCBI

29 

Nagashima AC, Giacomini D, Castro CP, Pereda MP, Renner U, Stalla GK, et al: Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells. Mol Cell Endocrinol. 201:47–56. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Schöbitz B, Van Den Dobbelsteen M, Holsboer F, Sutanto W and De Kloet ER: Regulation of interleukin 6 gene expression in rat. Endocrinology. 132:1569–1576. 1993.PubMed/NCBI

31 

Arzt E, Buric R, Stelzer G, Stalla J, Sauer J, Renner U, et al: Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology. 132:459–467. 1993.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang T, Zhao B, Li J, Zhang C, Li H, Wu J, Zhang S and Hui G: Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas. Mol Med Rep 11: 3027-3032, 2015.
APA
Zhang, T., Zhao, B., Li, J., Zhang, C., Li, H., Wu, J. ... Hui, G. (2015). Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas. Molecular Medicine Reports, 11, 3027-3032. https://doi.org/10.3892/mmr.2014.3062
MLA
Zhang, T., Zhao, B., Li, J., Zhang, C., Li, H., Wu, J., Zhang, S., Hui, G."Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas". Molecular Medicine Reports 11.4 (2015): 3027-3032.
Chicago
Zhang, T., Zhao, B., Li, J., Zhang, C., Li, H., Wu, J., Zhang, S., Hui, G."Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas". Molecular Medicine Reports 11, no. 4 (2015): 3027-3032. https://doi.org/10.3892/mmr.2014.3062
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang T, Zhao B, Li J, Zhang C, Li H, Wu J, Zhang S and Hui G: Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas. Mol Med Rep 11: 3027-3032, 2015.
APA
Zhang, T., Zhao, B., Li, J., Zhang, C., Li, H., Wu, J. ... Hui, G. (2015). Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas. Molecular Medicine Reports, 11, 3027-3032. https://doi.org/10.3892/mmr.2014.3062
MLA
Zhang, T., Zhao, B., Li, J., Zhang, C., Li, H., Wu, J., Zhang, S., Hui, G."Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas". Molecular Medicine Reports 11.4 (2015): 3027-3032.
Chicago
Zhang, T., Zhao, B., Li, J., Zhang, C., Li, H., Wu, J., Zhang, S., Hui, G."Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas". Molecular Medicine Reports 11, no. 4 (2015): 3027-3032. https://doi.org/10.3892/mmr.2014.3062
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