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Article

Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes

  • Authors:
    • Lysann Michaela Mehlig
    • Claudia Garve
    • Josephine Tabea Tauer
    • Meinolf Suttorp
    • Andrea Bauer
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, University Hospital Carl Gustav Carus, Dresden University of Technology, D‑01307 Dresden, Germany, Department of Pediatrics, Division of Pediatric Hematology and Oncology, University Hospital Carl Gustav Carus, Dresden University of Technology, D‑01307 Dresden, Germany
  • Pages: 3143-3147
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    Published online on: December 10, 2014
       https://doi.org/10.3892/mmr.2014.3074
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Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the presence of the BCR‑ABL1 fusion gene, a constitutively active, oncogenic tyrosine kinase that is responsible for the clinical features of CML. Tyrosine kinase inhibitors, such as imatinib, have markedly altered the treatment of CML. However, tyrosine kinase inhibitors are associated with side effects on bone metabolism, in adult and pediatric patients. Vitamin D3 is involved in the complex cycle of bone remodeling, therefore the present study aimed to investigate the influence of imatinib on vitamin D3 metabolism in the HaCaT human keratinocyte cell line, using commercially available enzyme assays. Imatinib was shown to significantly reduce the production of calcidiol and calcitriol. Based on interaction studies of imatinib with the cytochrome P450 (CYP450) inhibitors VID400 and ketoconazole, it is proposed that imatinib may interfere with the vitamin D3 cascade due to its metabolism by CYP27B1, which is involved in vitamin D3 metabolism.
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Copy and paste a formatted citation
Spandidos Publications style
Mehlig LM, Garve C, Tauer JT, Suttorp M and Bauer A: Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes. Mol Med Rep 11: 3143-3147, 2015.
APA
Mehlig, L.M., Garve, C., Tauer, J.T., Suttorp, M., & Bauer, A. (2015). Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes. Molecular Medicine Reports, 11, 3143-3147. https://doi.org/10.3892/mmr.2014.3074
MLA
Mehlig, L. M., Garve, C., Tauer, J. T., Suttorp, M., Bauer, A."Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes". Molecular Medicine Reports 11.4 (2015): 3143-3147.
Chicago
Mehlig, L. M., Garve, C., Tauer, J. T., Suttorp, M., Bauer, A."Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes". Molecular Medicine Reports 11, no. 4 (2015): 3143-3147. https://doi.org/10.3892/mmr.2014.3074
Copy and paste a formatted citation
x
Spandidos Publications style
Mehlig LM, Garve C, Tauer JT, Suttorp M and Bauer A: Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes. Mol Med Rep 11: 3143-3147, 2015.
APA
Mehlig, L.M., Garve, C., Tauer, J.T., Suttorp, M., & Bauer, A. (2015). Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes. Molecular Medicine Reports, 11, 3143-3147. https://doi.org/10.3892/mmr.2014.3074
MLA
Mehlig, L. M., Garve, C., Tauer, J. T., Suttorp, M., Bauer, A."Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes". Molecular Medicine Reports 11.4 (2015): 3143-3147.
Chicago
Mehlig, L. M., Garve, C., Tauer, J. T., Suttorp, M., Bauer, A."Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes". Molecular Medicine Reports 11, no. 4 (2015): 3143-3147. https://doi.org/10.3892/mmr.2014.3074
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