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Article

Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer

  • Authors:
    • Juntao Liu
    • Lei Shen
    • Jie Yao
    • Yi Li
    • Yongcheng Wang
    • Hong Chen
    • Peiliang Geng
  • View Affiliations / Copyright

    Affiliations: Department of General Thoracic Surgery, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China, Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Oncology, PLA Center Hospital, Wuhan, Hubei 430000, P.R. China, Oncology Department, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital, Beijing 100853, P.R. China, Orthopedics Department, Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Oncology, Kunming General Hospital of Chendu Military Command, Kunming, Yunnan 650032, P.R. China
  • Pages: 3155-3159
    |
    Published online on: December 15, 2014
       https://doi.org/10.3892/mmr.2014.3089
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Abstract

Recent studies have shown that long non‑coding RNAs (lncRNAs) have crucial regulating roles in carcinogenesis. Forkhead box C1 (FOXC1) is an important cancer‑associated gene in basal‑like breast cancer (BLBC). In the present study, a novel lncRNA, FOXC1 promoter upstream transcript (FOXCUT) was investigated in BLBC patients using polymerase chain reaction analysis. The results showed that the expression of FOXCUT and FOXC1 were positively correlated. When the expression of FOXCUT was downregulated by small interfering RNA, the expression of FOXC1 was similarly reduced. Furthermore, in MDA‑MB‑231 and MDA‑MB‑468 breast cancer cells, knockdown of FOXCUT markedly inhibited cell proliferation and migration in vitro. In conclusion, FOXCUT lncRNA may be functionally involved in the tumor progression of BLBCs through the regulation of its paired mRNA, FOXC1, demonstrating that FOXCUT may serve as a novel biomarker and therapeutic target in BLBCs.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Shen L, Yao J, Li Y, Wang Y, Chen H and Geng P: Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer. Mol Med Rep 11: 3155-3159, 2015.
APA
Liu, J., Shen, L., Yao, J., Li, Y., Wang, Y., Chen, H., & Geng, P. (2015). Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer. Molecular Medicine Reports, 11, 3155-3159. https://doi.org/10.3892/mmr.2014.3089
MLA
Liu, J., Shen, L., Yao, J., Li, Y., Wang, Y., Chen, H., Geng, P."Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer". Molecular Medicine Reports 11.4 (2015): 3155-3159.
Chicago
Liu, J., Shen, L., Yao, J., Li, Y., Wang, Y., Chen, H., Geng, P."Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer". Molecular Medicine Reports 11, no. 4 (2015): 3155-3159. https://doi.org/10.3892/mmr.2014.3089
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Shen L, Yao J, Li Y, Wang Y, Chen H and Geng P: Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer. Mol Med Rep 11: 3155-3159, 2015.
APA
Liu, J., Shen, L., Yao, J., Li, Y., Wang, Y., Chen, H., & Geng, P. (2015). Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer. Molecular Medicine Reports, 11, 3155-3159. https://doi.org/10.3892/mmr.2014.3089
MLA
Liu, J., Shen, L., Yao, J., Li, Y., Wang, Y., Chen, H., Geng, P."Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer". Molecular Medicine Reports 11.4 (2015): 3155-3159.
Chicago
Liu, J., Shen, L., Yao, J., Li, Y., Wang, Y., Chen, H., Geng, P."Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer". Molecular Medicine Reports 11, no. 4 (2015): 3155-3159. https://doi.org/10.3892/mmr.2014.3089
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