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Article

Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner

  • Authors:
    • Jianbo Wu
    • Zhen Lei
    • Jingui Yu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 2677-2682
    |
    Published online on: December 15, 2014
       https://doi.org/10.3892/mmr.2014.3093
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Abstract

Hypoxia has been widely implicated in numerous pathological conditions, including those associated with inflammation and tumorigenesis. A number of recent studies have implicated hypoxia in the control of microvascular damage, the basis for which is not fully understood. In the present study, it was identified that autophagy was induced in human umbilical vein endothelial cells (HUVECs) post treatment with hypoxia, and the induction of autophagy by hypoxia was enhanced by hypoxia‑inducible factor 1 (HIF‑1) gene overexpression and inhibited by HIF‑1 knockout. Furthermore, the autophagy induced by overexpression of HIF‑1 was associated with a reduction of HUVEC cell viability. Therefore, HIF‑1 reduced HUVEC cell viability by inducing autophagy. These findings provide evidence of an important link between hypoxia and microvascular damage associated with HIF‑1‑related autophagy.
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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Lei Z and Yu J: Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner. Mol Med Rep 11: 2677-2682, 2015.
APA
Wu, J., Lei, Z., & Yu, J. (2015). Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner. Molecular Medicine Reports, 11, 2677-2682. https://doi.org/10.3892/mmr.2014.3093
MLA
Wu, J., Lei, Z., Yu, J."Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner". Molecular Medicine Reports 11.4 (2015): 2677-2682.
Chicago
Wu, J., Lei, Z., Yu, J."Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner". Molecular Medicine Reports 11, no. 4 (2015): 2677-2682. https://doi.org/10.3892/mmr.2014.3093
Copy and paste a formatted citation
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Spandidos Publications style
Wu J, Lei Z and Yu J: Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner. Mol Med Rep 11: 2677-2682, 2015.
APA
Wu, J., Lei, Z., & Yu, J. (2015). Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner. Molecular Medicine Reports, 11, 2677-2682. https://doi.org/10.3892/mmr.2014.3093
MLA
Wu, J., Lei, Z., Yu, J."Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner". Molecular Medicine Reports 11.4 (2015): 2677-2682.
Chicago
Wu, J., Lei, Z., Yu, J."Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1‑dependent manner". Molecular Medicine Reports 11, no. 4 (2015): 2677-2682. https://doi.org/10.3892/mmr.2014.3093
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