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Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B

  • Authors:
    • Zhengju Xu
    • Xingnan Pan
    • Kaipeng Wei
    • Hongbing Ding
    • Meijuan Wei
    • Huanwen Yang
    • Qian Liu
  • View Affiliations / Copyright

    Affiliations: Clinical Liver Center, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China, Central Laboratory of Clinical Hepatology, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China, Liver Center Clinical Pathology, The 180th Hospital of the People's Liberation Army, Quanzhou, Fujian 362000, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2644-2652
    |
    Published online on: December 18, 2014
       https://doi.org/10.3892/mmr.2014.3114
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Abstract

The present study was designed to assess the correlation between serum Golgi protein 73 (GP73) and liver pathological grading and staging in patients with chronic hepatitis B (CHB). Two hundred and fifty‑three patients with chronic hepatitis B virus (HBV) infections were enrolled in the present study. All patients received a serum GP73 test, and 91 CHB patients underwent liver biopsy. GP73 expression in liver tissue was assessed by immunohistochemical analysis. The results indicated that serum GP73 levels were positively correlated with disease progression in patients with chronic HBV infection (r=0.677). There was no significant difference in serum GP73 levels between hepatitis B e antigen‑positive and ‑negative patients (P>0.05). There were also no significant differences in serum GP73 levels among specimens with varying HBV DNA contents (P>0.05). Serum GP73 levels were positively correlated with increased liver pathological grading (r=0.737) and staging (r=0.692), and immunohistochemical analysis indicated that GP73 protein expression increased concurrently with liver pathological grading and staging. In conclusion, serum GP73 was found to be correlated with liver pathological grading and staging in patients with CHB, and may be an effective indicator for the evaluation of disease progression. However, serum GP73 levels were not associated with HBV replication.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Z, Pan X, Wei K, Ding H, Wei M, Yang H and Liu Q: Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B. Mol Med Rep 11: 2644-2652, 2015.
APA
Xu, Z., Pan, X., Wei, K., Ding, H., Wei, M., Yang, H., & Liu, Q. (2015). Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B. Molecular Medicine Reports, 11, 2644-2652. https://doi.org/10.3892/mmr.2014.3114
MLA
Xu, Z., Pan, X., Wei, K., Ding, H., Wei, M., Yang, H., Liu, Q."Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B". Molecular Medicine Reports 11.4 (2015): 2644-2652.
Chicago
Xu, Z., Pan, X., Wei, K., Ding, H., Wei, M., Yang, H., Liu, Q."Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B". Molecular Medicine Reports 11, no. 4 (2015): 2644-2652. https://doi.org/10.3892/mmr.2014.3114
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Z, Pan X, Wei K, Ding H, Wei M, Yang H and Liu Q: Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B. Mol Med Rep 11: 2644-2652, 2015.
APA
Xu, Z., Pan, X., Wei, K., Ding, H., Wei, M., Yang, H., & Liu, Q. (2015). Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B. Molecular Medicine Reports, 11, 2644-2652. https://doi.org/10.3892/mmr.2014.3114
MLA
Xu, Z., Pan, X., Wei, K., Ding, H., Wei, M., Yang, H., Liu, Q."Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B". Molecular Medicine Reports 11.4 (2015): 2644-2652.
Chicago
Xu, Z., Pan, X., Wei, K., Ding, H., Wei, M., Yang, H., Liu, Q."Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B". Molecular Medicine Reports 11, no. 4 (2015): 2644-2652. https://doi.org/10.3892/mmr.2014.3114
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